KR-102963996-B1 - Pharmaceutical composition for antibacterial wound healing comprising chia seeds and biodegradable materials

Abstract

The present invention relates to a pharmaceutical composition for antibacterial wound treatment comprising chia seeds and a biodegradable material. The pharmaceutical composition of the present invention can be customized according to the wound and can be produced in a transparent form; it exhibits unique self-adhesive properties allowing it to be directly attached to the skin, etc.; it can withstand joint movement through excellent deformation adaptability and has high tensile strength. Furthermore, it possesses an antibacterial effect and an excellent wound healing effect.

Inventors

• 신용
• 교진

Assignees

• 연세대학교 산학협력단

Dates

Publication Date

20260512

Application Date

20230801

Claims (11)

1. A pharmaceutical composition for antimicrobial wound treatment comprising chia seed mucilage and a biodegradable material, The above biodegradable material is a composition comprising PVA (Polyvinyl alcohol), sorbitol, and glycerol.
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4. A pharmaceutical composition for antibacterial wound treatment according to claim 1, characterized by containing the chia seed viscous material in an amount of 0.5 to 2 w/v %.
5. A pharmaceutical composition for antibacterial wound treatment according to claim 1, characterized by containing the PVA in an amount of 0.5 to 2 w/v %.
6. A pharmaceutical composition for antibacterial wound treatment according to claim 1, characterized by containing 1.5 w/v % of the sorbitol.
7. A pharmaceutical composition for antibacterial wound treatment according to claim 1, characterized by containing 1.5 v/v % of the glycerol.
8. A wound dressing comprising the pharmaceutical composition of claim 1.
9. In claim 8, the wound dressing is a wound dressing in which the formulation is one or more selected from the group consisting of film type, cream type, gel type and spray type.
10. A cosmetic composition comprising chia seed mucilage and a biodegradable material, The above biodegradable material is a composition comprising PVA (Polyvinyl alcohol), sorbitol, and glycerol.
11. A quasi-drug composition comprising chia seed mucilage and a biodegradable material, The above biodegradable material is a composition comprising PVA (Polyvinyl alcohol), sorbitol, and glycerol.

Description

Pharmaceutical composition for antibacterial wound healing comprising chia seeds and biodegradable materials The present invention relates to a pharmaceutical composition for wound treatment, and more specifically, to an antibacterial pharmaceutical composition for wound treatment comprising chia seeds and a biodegradable material. Chia seeds are edible seeds of the annual herbaceous plant Salvia hispanica of the Lamiaceae family. They are rich in omega-3 and omega-6 fatty acids, vitamins, antioxidants, and minerals, and these nutritional properties have been widely verified and utilized in the food industry. Meanwhile, fully hydrated chia seed hulls release anionic heteropolysaccharides, and due to their high water retention capacity, high viscosity, and thickening effect, chia seed mucilage can be used as a thickener, gelling agent, and chelating agent in food and pharmaceuticals. However, current research on chia seeds is limited to food applications, and chia seed mucilage has not yet been developed as a promising emerging biomaterial. Polyvinyl alcohol (PVA) is a non-toxic, water-soluble polymer obtained by hydrolyzing polyvinyl acetate. Hydrogels made from PVA have excellent mechanical properties, controllability, and degradability, but their biocompatibility is inferior to that of natural polymers. However, the above properties of hydrogels can be improved by proportionally mixing PVA with other natural polymers. Some studies have proposed manufacturing electrospun and film products by mixing plant seed mucus, including chia seed mucilage, with PVA, but most focus on the analysis of mechanical properties and subsequent applications in the food and packaging sectors. Meanwhile, the skin is the largest surface of the human body in contact with the external environment; as the body's largest organ, it serves as the primary line of defense protecting the body from physical, chemical, and mechanical damage as well as biological invasion. Wounds are generally formed when external damaging factors act on the skin surface, and with the increasing prevalence of chronic diseases, chronic wounds such as drug-induced skin ulcers, pressure ulcers, and diabetic foot are also showing high incidence rates. Wounds generally vary in the degree of contamination due to rupture of the skin and mucous membranes at the site of injury and bleeding, and are prone to infection. Hydrogels currently sold on the market for wound treatment typically consist of a thin polyurethane layer coated with adhesive on one side and a moisture-proof film on the other. The additional adhesive can cause skin reactions or allergic responses in people with sensitive skin, and if left on the wound for a long time, it can become sticky when removed and cause further trauma to the wound site. At the same time, while commercial hydrofilms possess properties that protect wounds from external contaminants, this physical method may not be suitable for infected wounds as it can trap bacteria and delay healing. Additionally, a disadvantage is that they are currently more expensive than other wound dressings, placing a significant financial burden on patients. Therefore, there is a need for the development of a wound dressing with wound healing effects that has self-adhesive properties, is hypoallergenic, has antibacterial effects, and can be produced at low cost using readily available raw materials. Figure 1 shows a schematic diagram of the manufacturing process of an antibacterial wound healing pharmaceutical composition containing chia seeds and a biodegradable material. Figure 2 shows the results of manufacturing a film-type wound dressing according to the content of chia seed mucilage and PVA. Figure 3 shows the degree of swelling of film-type wound dressings in PBS according to the content of chia seed mucilage and PVA. Figure 4 shows the ratio of swelling height of film-type wound dressings according to the content of chia seed mucilage and PVA. Figure 5 is a photograph showing the transparency, adhesive properties, and deformation adaptability of a film-type wound dressing. Figure 6 shows an experiment to verify the tensile strength and peel strength of a film-type wound dressing. Figure 7 shows the swelling rate and decomposition rate of a film-type wound dressing over time. Figure 8 shows the antibacterial effect of a pharmaceutical composition for wound treatment. Figure 9 is a graph showing the biocompatibility of a pharmaceutical composition for wound treatment. Figure 10 shows the results of a scratch analysis of a pharmaceutical composition for wound treatment. Figure 11 is a photograph showing the wound healing results of a film-type wound dressing. Figure 12 shows the results of the analysis of the wound healing area of the film-type wound dressing. Figure 13 shows the thickness of the epithelial layer of the wound site evaluated using hematoxylin-eosin staining analysis. Figure 14 shows an additional analysis of the distribution of inf