KR-102965176-B1 - Insect repellent containing composition catnip extract as an active ingredient nepetalactone

Abstract

The present invention relates to an insect repellent composition containing nepetalactone. An insect repellent containing nepetalactone derived from catnip extract minimizes damage caused by mosquitoes and aims to improve upon the risks to humans or animals (vomiting and dizziness due to hyperventilation, and neurological problems) associated with commercially available chemical repellents. In other words, the insect repellent exhibits excellent repellent efficacy against pests such as mosquitoes without exposing humans and animals to the risks associated with chemical compounds, thereby protecting humans or animals from various infectious diseases caused by these pests.

Inventors

• 윤관한
• 하연서
• 김민영
• 성진우

Assignees

• 국립금오공과대학교 산학협력단

Dates

Publication Date

20260513

Application Date

20240126

Claims (7)

1. An insect repellent composition containing catnip extract containing nepetalactone as an active ingredient, An insect repellent composition characterized by including catnip, valerian, basil, ginger, cedarwood, frankincense, and agarwood in the above extract raw materials.
2. delete
3. In paragraph 1, An insect repellent composition characterized in that the insect is selected from pests consisting of mosquitoes, mites, fleas, and bedbugs.
4. An insect repellent cosmetic composition characterized by comprising the composition of claim 1.
5. In paragraph 4, A cosmetic composition characterized in that the formulation of the above composition is a spray formulation comprising ethanol, hyaluronic acid, glycerin, tocopherol, and 1,2-hexanediol.
6. An insect repellent external skin composition characterized by comprising the composition of claim 1.
7. In paragraph 6, A topical skin composition characterized in that the formulation of the above composition is a spray formulation comprising ethanol, hyaluronic acid, glycerin, tocopherol, and 1,2-hexanediol.

Description

Insect repellent composition containing catnip extract as an active ingredient nepetalactone The present invention relates to an insect repellent composition containing a catnip extract containing nepetalactone as an active ingredient. Today, due to climate change, the populations and timing of outbreaks of pests transmitted by mosquitoes and ticks—such as malaria, filariasis, encephalitis, dengue fever, and Zika virus disease—are increasing, and cases of infection by insects like mosquitoes are continuously rising in proportion to the surge in domestic and international travelers. Although these insect-borne diseases cause various aftereffects, effective vaccines have not yet been developed, making prevention from pests transmitted by mosquitoes and other insects essential for individuals. DEET (N, N diethyl-m-toluamide), which has been widely used as a mosquito and pest repellent to prevent viruses transmitted by pests, is a synthetic repellent that emits a characteristic unpleasant odor, irritates the skin, and can cause seizures in the elderly, infants, and children due to its rapid and strong skin penetration. Consequently, developed countries are gradually restricting its usage concentrations, making the development of natural repellents to replace it urgent. Accordingly, while researching various physiological activities of various natural products including catnip containing nepetalactone as an active ingredient, the inventors confirmed that the catnip or a complex natural product extract thereof has a useful mosquito repellent effect, thereby completing the present invention. Figure 1 shows the FT-IR spectrum graph of catnip extract. Preferred embodiments of the present invention will be described in detail below. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the content introduced herein is provided to fully convey the concept of the present invention to those skilled in the art, so that it may be thorough and complete. <Preparation Example 1. Preparation of Catnip Extract> Fresh catnip was dried outdoors for 48 hours and ground into a powder to make it suitable for extraction. 10g of catnip powder was added to 100ml of ethanol (anhydrous, 99.99%, 10 times its weight) and extracted at 30°C for 8 hours while stirring at 1000 rpm, followed by leaving at room temperature for 12 hours to obtain a catnip extract. Suspended solids were removed from the extract by filtration, and the solvent ethanol was removed by vacuum filtration to obtain the catnip extract. <Experimental Example 1. Confirmation of the presence of nepetalactone in catnip extract> The obtained catnip extract was qualitatively analyzed to confirm the presence or absence of nepetalactone. FT-IR was used for the analysis. As a result, as shown in Figure 1 and Table 1, the major peaks of nepetalactone—lactone carbonyl 1730cm⁻¹ , Trisubstituted alkene 1665–1675cm⁻¹ , Ester 1163–1260cm⁻¹ , Cyclopentane 1458cm⁻¹ , 2853cm⁻¹ , 2927cm⁻¹ , and 2997cm⁻¹ — were identified, confirming that nepetalactone was successfully extracted and contained as an active ingredient in the catnip extract. FunctionalstructurepeakLactone carbonyl1730 cm -1Trisubstituted alkeneC=C1665~1675 cm -1EsterC-O1163~1260 cm -1CyclopentaneCH1458 cm -1 2853 cm -1 2927 cm -1 2997 cm -1 <Experimental Example 2. Preparation of Test Mosquitoes> Test mosquitoes were obtained from the Disease Vector Control Division of the Korea Centers for Disease Control and Prevention (KCDC) and reared in designated rearing facilities in compliance with the Sanitary Insect Rearing Manual (Culex tritaeniorhynchus/Aedes albopictus). Rearing conditions were maintained at a temperature of 26–29°C and a humidity of 60–80%, suitable for mosquito rearing, with a photoperiod of 12 hours each for day and night. It takes approximately two weeks for a mosquito to emerge from a larva into a pupa; after about two days or more in the pupa stage, it emerges as an adult mosquito and lives for about 40 days. Therefore, adult mosquitoes that emerged from pupae were supplied with sugar water to ensure their survival, and this process was repeated to secure a sufficient number of mosquitoes necessary for the clinical trial. The mosquitoes used in the clinical trial for repellent efficacy were reared mosquitoes that had not sucked blood even once after mating, and the supply of sugar water was stopped 12 hours before the clinical trial to induce the mosquitoes to actively suck blood. At least 13 subjects were selected for the mosquito repellent efficacy test, regardless of gender, from the 20s to 50s age group. The selected subjects refrained from using perfumes and smoking, which could affect the repellent efficacy, for 12 hours prior to the test. Before the test, the test area was thoroughly washed with soap and water, then washed with a 70(v/v)% ethanol aqueous solution, and kept dry. <Experimental Example 3. Preparation of Mosquito Repe