KR-20260062205-A - Cosmetic compositions for skin improvement comprising exosomes of caviar

Abstract

The present invention relates to a composition for improving skin condition comprising caviar-derived exosomes, and more specifically, to a cosmetic composition for antioxidant, whitening, skin regeneration, anti-inflammatory, skin soothing and atopic dermatitis improvement comprising caviar-derived exosomes. The caviar-derived exosomes according to the present invention have activities that reduce reactive oxygen species generated by UV, inhibit extracellular melanin production, reduce intercellular gaps, inhibit nitric oxide production, reduce TSLP (Thymic stromal lymphopoietin) gene expression, increase filaggrin gene expression, and inhibit TARC (Thymus and Activation-regulated Chemokine) production, and are therefore highly effective as cosmetic ingredients for antioxidant, whitening, skin regeneration, anti-inflammatory, skin soothing, and improvement of atopic dermatitis.

Inventors

• 강희철
• 김미정
• 김지영
• 이수진

Assignees

• (주)지에프씨생명과학

Dates

Publication Date

20260507

Application Date

20241028

Claims (7)

1. A cosmetic composition for antioxidant, whitening, skin regeneration, anti-inflammatory, skin soothing, and improvement of atopic dermatitis containing caviar-derived exosomes as an active ingredient.
2. A cosmetic composition according to claim 1, characterized in that the caviar-derived exosomes are isolated and purified from sturgeon eggs.
3. A cosmetic composition according to claim 1, characterized in that the exosomes are extracellular vesicles having an average diameter of 50 to 200 nm.
4. A cosmetic composition according to claim 1, wherein the cosmetic composition is any one selected from the group consisting of shampoo, soap, rinse, surfactant-containing cleansing, skin, toner, cream, lotion, emulsion, serum, essence, suspension, emulsion, ointment, tonic, treatment, conditioner, paste, gel, oil, wax, spray, aerosol, mist, and powder.
5. A pharmaceutical composition for anti-inflammatory, prevention or treatment of atopic dermatitis and wound healing containing caviar-derived exosomes as an active ingredient.
6. A pharmaceutical composition for anti-inflammatory, prevention or treatment of atopic dermatitis and wound healing, characterized in that, in claim 5, the above pharmaceutical composition is administered or treated by injection, microneedling, iontophoresis, application, or a combination thereof.
7. A pharmaceutical composition for anti-inflammatory, prevention or treatment of atopic dermatitis and wound healing according to claim 5, characterized in that the above pharmaceutical composition is selected from the group consisting of a liquid formulation, a patch formulation, an injection formulation, an infusion formulation, and a spray formulation.

Description

Cosmetic compositions for skin improvement comprising exosomes of caviar The present invention relates to a composition for improving skin condition comprising caviar-derived exosomes, and more specifically, to a cosmetic composition for antioxidant, whitening, skin regeneration, anti-inflammatory, skin soothing and atopic dermatitis improvement comprising caviar-derived exosomes. The aging process occurs in all organs of the body, and the skin also undergoes aging as one gets older. Skin wrinkles are the most important and common symptom of aging skin, serving as a standard criterion for assessing the degree of aging. Recently, with improved living standards and increased interest in skin care, there has been growing interest in skin aging. While it is impossible to completely prevent skin aging, various attempts are being made to inhibit and slow down the aging process and its representative symptom, wrinkles. Skin aging is classified into intrinsic or extrinsic factors depending on the factors influencing it. The loss of the Extracellular Matrix (ECM) within the dermis, which is composed of collagen, elastin, fibronectin, and proteoglycans, is recognized as the primary cause of intrinsic skin aging. As the function of the ECM deteriorates, the skin becomes thin and flat, develops wrinkles, loses elasticity, and exhibits skin atrophy and dryness. Furthermore, the skin aging process leads to a decline in the function of accessory skin organs such as hair, sweat glands, and sebaceous glands, which can delay wound healing caused by external stimuli. In the case of ultraviolet (UV) radiation, an exogenous factor, exposure to UV rays has been reported to accelerate melanin production, causing skin aging and damage. Additionally, free radicals generated through UV radiation and respiration drive damage to skin cells and tissues. Excessive free radicals disrupt the body's antioxidant defense system, becoming a major factor in inflammatory responses, erythema, burns, immunosuppression, and DNA damage, ultimately accelerating skin aging. Moreover, stimuli from both exogenous and endogenous factors lead to a decrease in the moisture content of the stratum corneum and a reduction in natural moisturizing factors, resulting in decreased skin hydration and severe dryness; this ultimately leads to the destruction of the skin barrier. When skin becomes unbalanced in this way, its physical and chemical properties change, manifesting not only as wrinkles, pigmentation, reduced hydration, and skin barrier destruction, but also as inflammation and a decrease in cell regeneration capacity. Therefore, to delay and inhibit skin aging, an antioxidant defense system capable of suppressing and efficiently removing excess reactive oxygen species is required not only within the body but also within the skin. Accordingly, interest in materials for skin improvement is steadily increasing, and research on antioxidant and anti-aging properties, particularly regarding natural materials, is continuing. Caviar, referred to as the "jewel of the sea," began to attract attention as a cosmetic ingredient targeting skin moisturization, nourishment, and antioxidant effects, due to its rarity and the known content of nutrients such as amino acids, omega-3 fatty acids, vitamins, and minerals. In particular, following research by Ingrid Millet in 1964 that revealed caviar has a structure similar to human skin cells and the subsequent recognition of its skin-beautifying benefits, ingredients extracted from caviar—the eggs of the sturgeon—began to be widely used as raw materials for high-end cosmetics. However, as caviar is the eggs of the endangered sturgeon and requires preservation, there is a need to develop new ingredients that demonstrate high efficacy using small quantities of caviar. Recently, exosomes have been utilized in various fields, including biotechnology, pharmaceuticals, and cosmetics manufacturing. Exosomes refer to small, membrane-bound vesicles secreted by various cells, such as mammals, bacteria, and plants. As intercellular communication substances, exosomes are nano-sized materials ranging from 50 to 200 nm within extracellular vesicles. These nano-sized exosomes are composed of phospholipid bilayers, enabling them to transport membrane proteins. By enveloping their contents with a phospholipid bilayer, exosomes can protect their contents from external degradation agents. Furthermore, they facilitate easy intracellular penetration and perform various physiological and pathological functions, such as immune responses and signal transduction. Due to these characteristics, exosomes are widely used in cosmetic compositions. Consequently, research on extracting exosomes is actively underway. The inventor disclosed in Korean Patent No. 2426686 a cosmetic composition for improving skin wrinkles, improving skin hydration, and improving the skin barrier, containing exosomes derived from Beluga caviar, which is the eggs of a giant sturg