KR-20260062211-A - Whitening composition containing fishes enzyme hydrolyzate

Abstract

The present invention relates to a whitening composition containing enzymatic hydrolysate of fish skin as an active ingredient, which is free from fishy odor, making it easy to apply to the skin or ingest, and has a high absorption rate in the body, resulting in excellent skin whitening effects.

Inventors

• 강민철
• 이남혁
• 이새롬
• 강민경
• 김재훈
• 류아름
• 박정현
• 박희진
• 엄수진
• 이재훈
• 최윤상
• 송경모

Assignees

• 한국식품연구원
• 주식회사 쓰리에프씨

Dates

Publication Date

20260507

Application Date

20241028

Claims (14)

1. A cosmetic composition for whitening characterized by containing fish skin enzyme hydrolysate as an active ingredient.
2. A cosmetic composition for whitening according to claim 1, characterized in that the peptide weight-average molecular weight (Mw) of the fish skin enzyme hydrolysate is 1.0 to 4.0 kDa, the number-average molecular weight (Mn) is 0.3 to 1.0 kDa, and the volume-average molecular weight (Mz) is 2.0 to 4.0 kDa.
3. A cosmetic composition for whitening according to claim 1, wherein the above-mentioned fish skin enzyme hydrolysate is obtained by enzymatically decomposing a fish skin ultrasonic extract.
4. A cosmetic composition for whitening according to claim 3, wherein the fish skin ultrasonic extract is extracted with one or more acid solutions comprising acetic acid, formic acid, propionic acid, butyric acid, lactic acid, succinic acid, fumaric acid, malic acid, and citric acid.
5. A cosmetic composition for whitening according to claim 3, characterized in that the fish skin ultrasonic extract is treated at 40 to 90 ℃ for 20 to 80 minutes using an ultrasonic device with a frequency of 10 to 50 kHz and an amplitude of 80 to 100%.
6. A cosmetic composition for whitening according to claim 1, wherein the above-mentioned fish skin enzyme hydrolysate is a fish skin ultrasonic extract treated with an endotype enzyme.
7. A cosmetic composition for whitening according to claim 6, wherein the endotype enzyme is one or more selected from the group consisting of an enzyme derived from Bacillus licheniformis, an enzyme isolated from papaya sap, an animal-derived enzyme secreted from the stomach of a vertebrate, an animal-derived enzyme secreted from the pancreas of a vertebrate, an enzyme derived from Bacillus amyloliquefaciens, and an enzyme derived from Bacillus licheniformis and Bacillus amyloliquefaciens.
8. A cosmetic composition for whitening according to claim 7, wherein the enzyme derived from Bacillus licheniformis is Alcalase, the enzyme isolated from the papaya sap is Papain, the animal-derived enzyme secreted from the stomach of a vertebrate is Pepsin, the animal-derived enzyme secreted from the pancreas of a vertebrate is Trypsin, the enzyme derived from Bacillus amyloliquefaciens is Neutrase, and the enzyme derived from Bacillus licheniformis and Bacillus amyloliquefaciens is Protamex.
9. A cosmetic composition for whitening according to claim 3, characterized in that the fish skin enzyme hydrolysate is treated by mixing 0.3 to 1.0 parts by weight of enzyme with 100 parts by weight of fish skin ultrasonic extract.
10. A cosmetic composition for whitening characterized by containing a fraction of fish skin enzyme hydrolysate as an active ingredient.
11. A cosmetic composition for whitening according to claim 10, wherein the fraction of the fish skin enzyme hydrolysate comprises: a first fraction having a peptide weight-average molecular weight (Mw) of 1.0 to 3.0 kDa, a number-average molecular weight (Mn) of 0.3 to 1.0 kDa, and a volume-average molecular weight (Mz) of 2.0 to 4.0 kDa; or a second fraction having a peptide weight-average molecular weight (Mw) of 0.1 to 0.9 kDa, a number-average molecular weight (Mn) of 0.1 to 0.9 kDa, and a volume-average molecular weight (Mz) of 0.1 to 0.9 kDa.
12. A cosmetic composition for whitening according to claim 10, wherein the above-mentioned fish skin enzyme hydrolysate is obtained by enzymatically decomposing a fish skin ultrasonic extract.
13. A health functional food composition for whitening characterized by containing fish skin enzyme hydrolysate as an active ingredient.
14. A health functional food composition for whitening characterized by containing a fraction of fish skin enzyme hydrolysate as an active ingredient.

Description

Whitening composition containing fishes enzyme hydrolyzate as an active ingredient The present invention relates to a composition that has a high absorption rate in the body and is highly effective for skin whitening. Human skin is located on the outermost layer of the body, accounts for a significant portion of one's appearance, and is continuously exposed to external stimuli. Recently, as consumers' income and intellectual levels have risen, interest in skin beauty and health has increased significantly across various age groups, leading to the development of a wide variety of cosmetics that highlight more specialized and specific functions, such as whitening, anti-wrinkle effects, and UV protection. Human skin color is determined by the concentration and distribution of melanin, a black pigment, within the skin, and melanin is synthesized in melanocytes located in the epidermal layer of the skin. When an enzyme called tyrosinase acts on tyrosine, a type of amino acid, within melanosomes—organelles inside melanocytes—it is converted into DOPA and dopaquinone, after which melanin is produced through non-enzymatic oxidation reactions. Since excessive production of melanin darkens the skin color and causes blemishes and freckles, skin whitening can be achieved by inhibiting the activity of tyrosinase within the skin to suppress the production and accumulation of melanin. Meanwhile, due to their biological characteristics, seafood is easily damaged and deteriorates rapidly, making it prone to spoilage or decay. Furthermore, because seafood contains many inedible parts such as heads, internal organs, bones, and shells, a significant amount of by-products is generated during the production, distribution, processing, and sales processes. These fishery by-products cause various problems during the disposal process; if not properly treated, they lead to wastewater leakage and foul odors, as well as illegal landfilling and ocean dumping, which damage natural landscapes and cause environmental pollution. Furthermore, treating them entails significant socioeconomic costs. The disposal of fishery by-products is governed by the provisions of the 'Waste Management Act' and the 'Act on the Promotion of Resource Conservation and Recycling.' This is because, according to Article 2 (Definitions) of the 'Waste Management Act,' fishery by-products can be classified into waste and by-products that do not fall under the category of waste. Under the Waste Management Act, "waste" refers to "substances that are no longer needed for human life or business activities, such as garbage, combustion residue, sludge, waste oil, waste acid, waste alkali, and animal carcasses." In accordance with this regulation, among fishery by-products, "substances that are no longer needed for human life or business activities" are classified as waste and must undergo the treatment processes prescribed by the Act. Consequently, most fishery by-products are treated as waste. As an exceptional case, if aquatic by-products are deemed to be "necessary for human life or business activities" at the business establishment where they first originate, they are considered by-products rather than waste. For example, when a fishery processing plant processes fish and manufactures by-products such as salted fish paste or fish sauce at the same establishment, if the product is registered as a product of the establishment, it is excluded from being considered waste. Regarding the resource utilization of fishery by-products, fish by-products are primarily used for fishmeal, fertilizer, and animal feed. Shellfish by-products, on the other hand, are utilized for fertilizer, spat cultivation materials, and animal feed. Meanwhile, concerning disposal, fishery by-products are disposed of through incineration, landfill, or ocean dumping. Furthermore, the reality is that there are many cases where by-products are stockpiled or abandoned without undergoing resource utilization or disposal, or are illegally incinerated, landfilled, or dumped into the ocean. Recently, various efforts are being made both domestically and internationally to create new value by minimizing the disposal of natural resources due to depletion and utilizing them as circular resources. If fishery by-products are also transformed into eco-friendly resources, it will not only resolve issues such as environmental pollution and disposal costs but also enable the development of new value-added industries. Based on this, many attempts are being made both at home and abroad to transform fishery by-products, which were previously simply discarded, into eco-friendly resources or resources capable of generating high added value. For example, there have been attempts to use collagen, which is contained in large quantities in fish skin (fish skin), which accounts for about 5 to 10% of the fish's body weight, as a material for repairing human skin such as wounds. The present invention aims to provide a composition t