KR-20260062679-A - Sensing apparatus and method for performing antibiotic susceptibility test

KR20260062679AKR 20260062679 AKR20260062679 AKR 20260062679AKR-20260062679-A

Abstract

A sensing device and a method for diagnosing antibiotic susceptibility using the same are disclosed. A sensing device according to one aspect of the present invention comprises: a receiving module in which a fluid introduced through an open upper surface can be received on a lower surface; a first plate member formed such that at least one receiving module is coupled thereto and the receiving module is formed to allow fluid communication in the vertical direction; and a second plate member coupled to the first plate member on an upper surface, wherein at least one sensor for sensing the fluid is formed on the upper surface and an electrode capable of detecting a signal sensed by the sensor is formed on the lower surface. A method for diagnosing antibiotic susceptibility according to another aspect of the present invention comprises: (a) a step of coating an antibiotic on the sensor; (b) a step of injecting the fluid containing a microorganism into the receiving module; and (c) a step of detecting an electrical signal of the fluid to diagnose the antibiotic susceptibility of the microorganism.

Inventors

임국진
최연식
오제승
신석교
김태영

Assignees

주식회사 프로티아

Dates

Publication Date: 20260507
Application Date: 20241029

Claims (13)

A receiving module in which fluid introduced through an open upper surface can be received in a lower surface; A first plate member in which at least one of the above-mentioned receiving modules is coupled and the above-mentioned receiving module is formed to be fluidly communicable in the vertical direction, and A sensing device comprising a second plate member coupled to the first plate member on an upper surface, wherein at least one sensor for sensing the fluid is formed on the upper surface and an electrode capable of detecting a signal sensed by the sensor is formed on the lower surface.
In Article 1, The above receiving module is a sensing device in which the cross-sectional shape of the upper surface is wider than the cross-sectional shape of the lower surface, and the cross-sectional shape decreases from the top to the bottom.
In Article 1, A sensing device having at least one receiving hole formed in the first plate member so as to accommodate at least one receiving module.
In Article 1, The above sensor is a body in which a change in the electrical characteristics of the fluid can be measured; A sensing device comprising a first hole connected to the body in a second direction of the body and electrically connected to the body, and a second hole connected to the body in a direction opposite to the second direction of the body and electrically connected to the body.
In Article 4, A sensing device having a cross electrode formed in the above body.
In Article 5, The sensor above is a sensing device that measures the electrical capacitance of the fluid.
In Article 4, A sensing device in which the electrodes are provided in plurality, and the plurality of electrodes are formed to correspond to the first hole and the second hole.
In Article 1, The above sensors are a sensing device housed inside the lower surface of the above receiving module.
In Article 1, A sensing device in which the second plate member is a PCB substrate.
In Article 1, The above sensing device is a sensing device that diagnoses antibiotic susceptibility of microorganisms in the fluid.
In Article 10, A sensing device in which an antibiotic is coated on the sensor above.
A method for diagnosing antibiotic susceptibility using a sensing device according to any one of claims 1 to 11, (a) A step of coating the above sensor with an antibiotic; (b) a step of injecting the fluid containing microorganisms into the receiving module and (c) A method for diagnosing antibiotic susceptibility, comprising the step of detecting an electrical signal of the fluid to diagnose the antibiotic susceptibility of the microorganism.
In Article 12, The step of (c) diagnosing the antibiotic susceptibility of the microorganism using the sensor above is a method for diagnosing antibiotic susceptibility of the microorganism by measuring the electrical capacitance of the fluid through the sensor.

Description

Sensing apparatus and method for performing antibiotic susceptibility test The present invention relates to a sensing device and a method for diagnosing antibiotic susceptibility using the same, and more specifically, to a sensing device using a sensor and an electrode and a method for diagnosing antibiotic susceptibility using the same. Among the various diseases that occur in the human body, there are those caused by microbial infections, including urinary tract infections and sepsis. To treat diseases caused by such microbial infections, antibiotics are required to inhibit the proliferation of microorganisms, and antibiotics either suppress the growth of microorganisms or kill them. However, more than 100 types of antibiotics have been developed to date, and their effectiveness varies depending on the type of microorganism or whether it is resistant to antibiotics. Therefore, the most effective antibiotic must be selected for each patient, and the diagnostic test method for this purpose is called antibiotic susceptibility testing. For such antibiotic susceptibility testing, the structure is designed to test antibiotic susceptibility through a sensor within a space containing a fluid that includes antibiotics and microorganisms. Korean Registered Patent Publication No. 10-2570520 discloses a biosensor using a PET substrate, a method for manufacturing the same, and a method for testing the antibiotic susceptibility of microorganisms using the same. However, in such antibiotic susceptibility diagnostic methods, there are cases where electrical signals are not transmitted properly due to the formation of bubbles in the space containing the fluid containing antibiotics and microorganisms. Therefore, there is an urgent need to develop technology that prevents bubble formation in the space containing the fluid containing antibiotics and microorganisms for antibiotic susceptibility testing, thereby enabling the effective transmission of electrical signals. FIG. 1 is a perspective view of a sensing device according to one embodiment of the present invention. FIG. 2 is an exploded view of a sensing device according to one embodiment of the present invention. FIG. 3 is a perspective view of a receiving module according to one embodiment of the present invention. FIG. 4 is a perspective view of a first plate member according to one embodiment of the present invention. FIG. 5 is a perspective view of a second plate member according to one embodiment of the present invention. FIG. 6 is a plan view of a second plate member according to one embodiment of the present invention. FIG. 7 is a bottom view of a second plate member according to one embodiment of the present invention. FIG. 8 is a drawing illustrating that a sensor according to one embodiment of the present invention is received on the lower surface of a receiving module. FIG. 9 is a flowchart illustrating a method for diagnosing antibiotic susceptibility according to one embodiment of the present invention. Hereinafter, embodiments of the present invention are described in detail with reference to the attached drawings so that those skilled in the art can easily implement the invention. The present invention may be embodied in various different forms and is not limited to the embodiments described herein. To clearly explain the present invention, parts unrelated to the description in the drawings have been omitted, and the same reference numerals have been used throughout the specification for identical or similar components. The words and terms used in this specification and claims are not limited to their ordinary or dictionary meanings, but should be interpreted in a meaning and concept consistent with the technical spirit of the invention in accordance with the principles by which the inventor defines terms and concepts to best describe his invention. Therefore, the embodiments described in this specification and the configurations illustrated in the drawings correspond to preferred embodiments of the present invention and do not represent all technical concepts of the present invention; thus, various equivalents and modifications that may replace such configurations may exist at the time of filing the present invention. In this specification, terms such as “comprising” or “having” are intended to describe the existence of the features, numbers, steps, actions, components, parts, or combinations thereof described in the specification, and should not be understood as precluding the existence or addition of one or more other features, numbers, steps, actions, components, parts, or combinations thereof. The statement that a component is "in front," "rear," "upper," or "lower" of another component includes, unless there are special circumstances, not only being positioned "in front," "rear," "upper," or "lower" in direct contact with the other component, but also cases where another component is positioned in between. Furthermore, the statement that a componen