KR-20260062994-A - SOLUTION COMPRISING NICOTINE IN UNPROTONATED FROM AND PROTONATED FORM

Abstract

(i) a carrier; (iii) nicotine in a non-protonated form and a protonated form; and (iv) a nicotine solution comprising one or more acids, wherein at least benzoic acid, levulinic acid, or a mixture thereof is present, and the total content of the acid present in the solution is 0.6 molar equivalents or less based on nicotine.

Inventors

• 맥아담, 케빈 제랄드
• 브루튼, 코너

Assignees

• 니코벤처스 트레이딩 리미티드

Dates

Publication Date

20260507

Application Date

20151106

Priority Date

20141107

Claims (20)

1. (i) carrier; (ii) nicotine in its non-protonated and protonated forms; and (iii) a nicotine solution comprising at least one acid, wherein at least benzoic acid, levulinic acid, or a mixture thereof is present, as one or more acids, A nicotine solution in which the total acid content present in the solution is 0.6 molar equivalents or less based on nicotine.
2. A nicotine solution according to claim 1, further comprising water.
3. A nicotine solution according to claim 1 or 2, wherein at least benzoic acid is present.
4. A nicotine solution containing an acid selected from the group consisting of benzoic acid, in any one of claims 1 to 3.
5. A nicotine solution containing an acid selected from the group consisting of levulinic acid, in any one of claims 1 to 3.
6. A nicotine solution according to any one of claims 1 to 5, wherein the total content of acid present in the solution is 0.5 molar equivalents or less based on nicotine.
7. A nicotine solution according to any one of claims 1 to 6, wherein the total content of acid present in the solution is 0.2 molar equivalents or more based on nicotine.
8. A nicotine solution according to any one of claims 1 to 8, wherein the amount of benzoic acid present in the solution is 0.2 molar equivalents or more based on nicotine.
9. A nicotine solution according to any one of claims 1 to 8, wherein the combined amount of benzoic acid and levulinic acid present in the solution is 0.2 to 0.4 molar equivalents based on nicotine.
10. A nicotine solution according to any one of claims 1 to 9, wherein the amount of benzoic acid present in the solution is 0.2 to 0.4 molar equivalents based on nicotine.
11. A nicotine solution comprising an amount of nicotine of 2 wt% or less based on the total weight of the solution, in any one of claims 1 to 10.
12. A nicotine solution comprising an amount of nicotine of 1.8 wt% or less based on the total weight of the solution, in any one of claims 1 to 10.
13. A nicotine solution according to any one of claims 1 to 12, containing an acid selected from the group consisting of levulinic acid, and containing an amount of nicotine of 1.8 wt% or less based on the total weight of the solution.
14. A nicotine solution in which the carrier is the solvent, in any one of claims 1 to 13.
15. In claim 14, a nicotine solution in which the solvent is selected from glycerol, propylene glycol, and mixtures thereof.
16. (a) container; and (b) (i) a carrier; (ii) nicotine in a non-protonated form and a protonated form; and (iii) a nicotine solution containing one or more acids, wherein at least one acid is present, at least benzoic acid, levulinic acid, or a mixture thereof, wherein A nicotine solution containing a total acid content of 0.6 molar equivalents or less based on nicotine.
17. In paragraph 16, a nicotine solution containing water additionally.
18. In Clause 17, a nicotine solution containing a container configured to be interlocked with an electronic vapor supply system.
19. In any one of claims 16 to 18, the nicotine solution is a nicotine solution containing the nicotine solution as defined in any one of claims 2 to 15.
20. A vaporizer for vaporizing liquid for inhalation by a user of an electronic vapor supply system; A power supply device including a cell or battery for supplying power to a carburetor; and (i) carrier; (ii) nicotine in its non-protonated and protonated forms; and (iii) an electronic vapor supply system comprising a nicotine solution comprising at least one acid, wherein at least benzoic acid, levulinic acid, or a mixture thereof is present as one or more acids, An electronic vapor supply system in which the total acid content present in the solution is 0.6 molar equivalents or less based on nicotine.

Description

Solution comprising nicotine in unprotonated and protonated forms The disclosure of the present invention relates to a nicotine solution, a container containing the nicotine solution, and an electronic vapor supply system comprising said solution, e.g., an electronic nicotine delivery system (e.g., an electronic cigarette). Electronic vapor delivery systems, such as electronic cigarettes, typically contain a reservoir of vaporizable liquid containing nicotine. When a user inhales from the device, a heating element is activated, vaporizing a small amount of liquid, which is then inhaled by the user. The use of e-cigarettes is increasing rapidly in the UK, and it is estimated that over one million people currently use them. One challenge faced in providing the above system is to provide inhaled vapor from a vapor supply device that offers a satisfactory experience to the consumer. Some consumers may prefer electronic cigarettes that generate aerosols that closely 'mimicking' the smoke inhaled from tobacco products, e.g., cigarettes. The aerosols from electronic cigarettes and the smoke from tobacco products, e.g., cigarettes, provide the user with a complex series of flavors in the mouth, followed by nicotine absorption in the lungs after nicotine absorption in the mouth and throat. These various aspects are described by the user in relation to flavor, intensity/quality, impact, stimulation/smoothness, and nicotine reward. Nicotine contributes to many of these factors and is strongly associated with factors such as impact, stimulation, and smoothness; these are easily perceived by the consumer, and electronic cigarettes may provide the consumer with too much or too little of these parameters depending on personal preference. Nicotine compensation is particularly complex because it arises from both the amount and rate of nicotine absorbed by the inner layers of the mouth (typically vaporized nicotine) and the amount and rate of nicotine absorbed by the lungs (typically particulate nicotine in inhaled aerosols). Each of these factors, and their balance, can significantly contribute to the consumer acceptability of electronic cigarettes. Therefore, it is desirable to provide electronic cigarette manufacturers with the means to optimize the overall vaping experience. In one mode, (i) carrier; (ii) nicotine in its non-protonated and protonated forms; and (iii) A nicotine solution is provided comprising at least one acid, wherein at least benzoic acid, levulinic acid, or a mixture thereof is present as one or more acids, and, The total acid content present in the solution is 0.6 molar equivalents or less based on nicotine. In one mode, (a) container; and (b) (i) a carrier; (ii) nicotine in a non-protonated form and a protonated form; and (iii) a nicotine solution comprising one or more acids, wherein at least one acid is present, at least benzoic acid, levulinic acid, or a mixture thereof, and a contained nicotine solution is provided, and The total acid content present in the solution is 0.6 molar equivalents or less based on nicotine. In one mode, A vaporizer for vaporizing liquid for inhalation by a user of an electronic vapor supply system; A power supply device including a cell or battery for supplying power to a carburetor; and (i) carrier; (ii) nicotine in its non-protonated and protonated forms; and (iii) An electronic vapor supply system is provided comprising a nicotine solution comprising at least one acid, wherein at least benzoic acid, levulinic acid, or a mixture thereof is present as one or more acids, and The total acid content present in the solution is 0.6 molar equivalents or less based on nicotine. In one mode, (a) (i) a carrier; (ii) nicotine in a non-protonated form and a protonated form; and (iii) a step of providing a nicotine solution comprising at least one acid, wherein at least benzoic acid, levulinic acid, or a mixture thereof is present as one or more acids; and (b) A method for improving the sensory properties of a vaporized nicotine solution is provided, comprising the step of vaporizing a nicotine solution, and The total acid content present in the solution is 0.6 molar equivalents or less based on nicotine. In one embodiment, the use of one or more acids to improve the sensory properties of a vaporized nicotine solution is provided, and the nicotine solution is, (i) carrier; (ii) nicotine in its non-protonated and protonated forms; and (iii) one or more acids, comprising at least one acid in which benzoic acid, levulinic acid, or a mixture thereof is present, and The total acid content present in the solution is 0.6 molar equivalents or less based on nicotine. details As discussed herein, the present invention provides a nicotine solution comprising (i) a carrier; (ii) nicotine in a non-protonated form and a protonated form; and (iii) one or more acids, wherein at least one acid is present, wherein benzoic acid, levulinic acid, or a mixture thereof, and the total content of the aci