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KR-20260063367-A - Composition for Anti-wrinkles, Anti-inflammation, Skin Regeneration, and Pore Tightening Comprising Fermented Extract of Apple and Aloe as Active Ingredient

KR20260063367AKR 20260063367 AKR20260063367 AKR 20260063367AKR-20260063367-A

Abstract

The present invention relates to a composition for improving skin condition comprising a complex fermented extract of apple and aloe as an active ingredient. The complex fermented extract of apple and aloe of the present invention has no cytotoxicity, promotes cell growth, promotes the production of type 1 procollagen, and inhibits the expression of MMP-1 protein, a collagen-degrading enzyme, making it effective for skin wrinkles; it also effectively inhibits the production of nitric oxide, an inflammatory mediator, exhibiting excellent anti-inflammatory activity; it promotes skin regeneration and shows excellent effects on skin pore contraction, so it can be usefully utilized in cosmetics, food, and quasi-drugs for improving skin condition. Furthermore, the skin condition improvement composition of the present invention is not only very safe for the human body, but also has excellent stability.

Inventors

  • 엄석종

Assignees

  • 엄석종

Dates

Publication Date
20260507
Application Date
20241030

Claims (9)

  1. A cosmetic composition for improving skin condition comprising a complex fermented extract of apple and aloe as an active ingredient.
  2. In paragraph 1, The above apple and aloe are characterized by being blended in a weight ratio of 1:0.8 to 1.2 based on the raw materials. Cosmetic composition for improving skin condition.
  3. In paragraph 1, The above complex fermented extract is characterized as a complex fermented extract obtained by fermenting a complex extract of apple and aloe with the Lactobacillus rhamnosus Farmic_18 strain (accession number KCTC 16064BP). Cosmetic composition for improving skin condition.
  4. In paragraph 1, The above complex fermented extract is characterized by increasing the expression of type I procollagen protein and inhibiting the expression of MMP-1 protein. Cosmetic composition for improving skin condition.
  5. In paragraph 1, The above-mentioned complex fermented extract is characterized by exhibiting anti-inflammatory activity by inhibiting the production of nitric oxide (NO), an inflammatory mediator. Cosmetic composition for improving skin condition.
  6. In paragraph 1, The above-mentioned complex fermented extract is characterized by promoting the regeneration of skin cells, Cosmetic composition for improving skin condition.
  7. In paragraph 1, The above-mentioned complex fermented extract is characterized by exhibiting skin pore-tightening activity. Cosmetic composition for improving skin condition.
  8. A food composition for improving skin condition comprising a complex fermented extract of apple and aloe as an active ingredient.
  9. A quasi-drug composition for improving skin condition comprising a complex fermented extract of apple and aloe as an active ingredient.

Description

Composition for anti-wrinkles, anti-inflammation, skin regeneration, and pore tightening comprising a complex fermented extract of apple and aloe as an active ingredient The present invention relates to a composition for improving skin condition comprising a complex fermented extract of apple and aloe as an active ingredient, and more specifically, to a composition for improving skin condition that exhibits excellent effects in skin regeneration, pore tightening, inflammation improvement, and wrinkle improvement by fermenting apple and aloe with a Lactobacillus rhamnosus strain. Some of the substances that play a crucial role in maintaining homeostasis in living organisms are physiologically active substances derived from various organisms. Extensive research has been conducted on numerous physiologically active substances to date, and among them, the study of physiologically active substances isolated from microorganisms, plants, or animals is a very important area in the fields of life science and medicine. Conventional substances known to be effective for improving skin wrinkles and elasticity, as well as for moisturizing, whitening, and antioxidant properties, include Vitamin C, retinoic acid, and transforming growth factor (TGF). However, materials such as Vitamin C, retinoic acid, transforming growth factor (TGF), animal placenta-derived protein (JP Publication No. 1996-231370), betulinic acid (JP Publication No. 1996-208424), and Chlorella extract (JP Publication No. 2001-072567) have had problems such as limitations on usage due to safety concerns like irritation and redness when applied to the skin, or their effects being so minimal that they cannot practically be expected to have any effect on the skin. Furthermore, there is a recent trend of active development in cosmetics that enhance functionality by introducing physiologically active substances derived from natural sources to further strengthen the skin's own inherent defense mechanisms. Consequently, there is an urgent need for the development of natural materials that are safe for the body, have stable active ingredients, and, above all, are more effective than existing substances for improving skin wrinkles, reducing inflammation, regenerating skin cells, and shrinking pores. Meanwhile, cosmetic ingredients must strike a balance between safety, efficacy, and physical properties. Furthermore, as economic feasibility is a crucial factor, cosmetic materials are developed using various methods, such as natural extraction and fermentation by microorganisms, to optimize skin penetration, anti-aging properties, physiological activity, safety, and physical characteristics. Moreover, as the boundaries between cosmetics, food, and pharmaceuticals blur, a diverse range of cosmeceutical products continues to experience high growth through complex functional ingredients and biomaterials that combine the safety of cosmetics with the efficacy of pharmaceuticals and health functional foods. Against this backdrop, the inventors made diligent research efforts to discover a combination of natural extracts that can be actively utilized in the field, as they exhibit excellent effects in improving skin conditions such as reducing skin wrinkles, reducing inflammation, regenerating skin cells, and shrinking skin pores. As a result, it was confirmed that the skin condition improvement effect of natural materials is increased to a certain extent by combining apple and aloe, and furthermore, a complex fermented extract obtained by fermenting the complex extract of apple and aloe with a Lactobacillus rhamnosus strain has no cytotoxicity, promotes cell growth, promotes the production of type 1 procollagen, inhibits the expression of MMP-1 protein—a collagen-degrading enzyme—to be effective against skin wrinkles, inhibits the production of nitric oxide—an inflammatory mediator—to exhibit excellent anti-inflammatory activity, promotes skin regeneration, and exhibits excellent effects on shrinking skin pores. Thus, the present invention was completed. Figure 1 is a graph showing the change in cell viability measured by treatment with apple extract, aloe extract, a complex extract of apple and aloe, and a complex fermented extract of apple and aloe. Figure 2 is a graph summarizing the changes in expression of type I procollagen protein according to treatment with apple extract, aloe extract, a complex extract of apple and aloe, and a complex fermented extract of apple and aloe. Figure 3 is a graph summarizing the changes in MMP-1 protein expression according to treatment with apple extract, aloe extract, a complex extract of apple and aloe, and a complex fermented extract of apple and aloe. Figure 4 is a graph summarizing the changes in nitric oxide production according to treatment with apple extract, aloe extract, a complex extract of apple and aloe, and a complex fermented extract of apple and aloe. Figure 5 is a graph summarizing the skin wound regeneration activity me