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KR-20260063476-A - Oral device cleaning agent composition having a bactericidal effect against oral bacteria

KR20260063476AKR 20260063476 AKR20260063476 AKR 20260063476AKR-20260063476-A

Abstract

The present invention relates to a composition for cleaning oral appliances comprising, as an active ingredient, a complex containing Haematococcus pluvialis extract, myrrh resin extract, sea grape extract, oak moss extract, green tea extract, lactoferrin, and peppermint oil. Such a complex has excellent antibacterial/antifungal effects against oral bacteria and fungi such as Streptococcus mutans , Porphyromonas gingivalis , Candida albicans , and Acinetobacter johnsonii , has efficacy in preventing bad breath/stomatitis, and can prevent tartar from accumulating on oral appliances. Accordingly, by using the composition of the present invention, users of oral devices such as braces, jaw joint correctors, bruxism prevention devices, and dentures can maintain more hygienic and clean oral care.

Inventors

  • 최현성

Assignees

  • 주식회사 바오메디텍

Dates

Publication Date
20260507
Application Date
20241030

Claims (9)

  1. An oral appliance cleaning composition characterized by comprising, as an active ingredient, a complex containing Haematococcus pluvialis extract, myrrh resin extract, sea grape extract, oak moss extract, green tea extract, lactoferrin, and peppermint oil.
  2. In paragraph 1, The above-mentioned compound is an oral appliance cleaning composition characterized by having plaque removal efficacy.
  3. In paragraph 1, The above-mentioned complex is an oral appliance cleaning composition characterized by having bactericidal and antibacterial efficacy against Streptococcus mutans, a cavity-causing bacterium in the oral cavity.
  4. In paragraph 1, The above-mentioned complex is an oral appliance cleaning composition characterized by having bactericidal and antibacterial efficacy against Porphyromonas gingivalis , a bad breath-causing bacterium.
  5. In paragraph 1, The above-mentioned compound is an oral appliance cleaning composition characterized by having antifungal efficacy against Candida albicans, a causative agent of stomatitis.
  6. In paragraph 1, The above-mentioned complex is an oral appliance cleaning composition characterized by having antifungal efficacy against Acinetobacter johnsonii, a causative agent of stomatitis.
  7. In paragraph 1, An oral appliance cleaning composition characterized by comprising eucalyptus oil, calendula extract, chamomile extract, papain, protease, lysozyme, ethanol, sodium bicarbonate, L-menthol, glycerin, cocamidopropyl betaine, sodium cocoyl glutamate, floxamer 407, hydrogenated castor oil, fragrance, and purified water in the above complex.
  8. In paragraph 1, The above composition is an oral appliance cleaning composition characterized by preventing the formation of tartar on the exterior of the oral appliance.
  9. In paragraph 1, An oral device cleaning composition characterized in that the above oral device is selected from a tooth brace, an orthodontic brace, a temporomandibular joint orthodontist, a bruxism prevention device, or a denture.

Description

Oral device cleaning agent composition having a bactericidal effect against oral bacteria The present invention relates to an oral appliance cleaning composition having bactericidal efficacy against oral bacteria. The number of people using various oral appliances, such as devices for orthodontics, temporomandibular joint correction, and bruxism prevention, as well as dentures, is increasing. Consequently, the cleaning of these appliances is closely linked to dental health and oral diseases. Therefore, the removal of dental plaque—composed of microorganisms and their byproducts adhering to the surface of these appliances—is crucial. Currently, various physical devices or chemical compositions are primarily available to remove deposits like dental plaque; thus, there is a growing need for natural-type oral appliance cleaners that are easy to use and harmless to the human body. While imported products developed abroad are manufactured in tablet form in the recent market, they are inconvenient to use after every meal, leading consumers to use toothpaste or dish soap as substitutes. Accordingly, the inventors confirmed that a hygienic oral environment can be maintained by using a composition containing various natural extracts and protein enzymes with excellent antibacterial, deodorizing, and cleaning efficacy as an oral appliance cleaning composition, and thus completed the present invention. Preferred embodiments of the present invention will be described in detail below. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the content introduced herein is provided to fully convey the concept of the present invention to those skilled in the art, so that it may be thorough and complete. <Examples 1 to 3 and Comparative Examples 1 to 3. Preparation of Natural Product-Derived Complexes> Haematococcus Pluvialis extract, myrrh resin extract, sea grape ( Caulerpa lentillifera ) extract, oak moss ( Evernia Prunastri ; Oakmoss) extract, green tea leaf extract, lactoferrin, and peppermint oil, which are the main active ingredients of the oral appliance cleaning composition of the present invention, were first mixed as shown in Table 1 below to first confirm the efficacy of various antibacterial and bad breath prevention effects. This is also a procedure to select the most effective one as a cleansing agent composition and to verify appropriate mixing conditions or formulation stabilization conditions with the remaining ingredients, such as eucalyptus oil, calendula flower extract, chamomile flower extract, papain, protease, lysozyme, ethanol, sodium bicarbonate, L-menthol, glycerin, cocamidopropyl betaine, sodium cocoyl glutamate, floxamer 407, hydrogenated castor oil, grapefruit seed extract prepared as a fragrance, and purified water. IngredientsExample 1Example 2Example 3　Comparative Example 1Comparative Example 2Comparative Example 3Haematococcus Pluvialis extract (g)1.001.001.00　0.001.001.00Myrrh resin extract (g)3.002.502.50　0.002.001.00Sea grape extract (g)2.803.002.50　1.004.001.00Oak moss extract (g)3.003.503.50　0.003.001.00Green tea extract (g)2.001.001.50　5.000.000.50Lactoferrin (g)0.100.500.50　1.000.001.00Peppermint oil (g)10.1010.5010.50　15.0012.0016.50Subtotal (g)22.0022.0022.00　22.0022.0022.00 Each extract used as a raw material was prepared by adding 10 times its weight of a 70% (v/v) ethanol aqueous solution to a raw material sample (plant, seaweed, moss, resin) and extracting it at 60°C for 8 hours, then concentrating the resulting liquid under reduced pressure and freeze-drying it. Peppermint oil and eucalyptus oil to be used later were purchased as products manufactured as essential oils. Other raw materials, such as excipients and enzymes, were purchased and used as ingredients commonly used in food or mouthwashes. <Formulation Examples 1 to 3 and Comparative Formulation Examples 1 to 5. Preparation of Formulation Compositions> Formulation compositions were prepared as shown in Tables 2 and 3, using the composite components and content of Example 1 as a representative example. To this end, six types of excipients corresponding to each formulation composition were prepared and compared. The compositions in Tables 2 and 3 were prepared to verify the formulation state according to the content of excipients and the presence or absence of ingredients, and Table 4 is a formulation composition prepared using the components and content of the complex of Comparative Example 3, but there are also differences in the excipients. IngredientsFormulation Example 1 Weight of each ingredient (g)Formulation Example 2 Weight of each ingredient (g)Formulation Example 3 Weight of each ingredient (g)Haematococcus pluvialis extractline city yes 1 luck bout water1.00line city yes 1 luck bout water1.00line city yes 1 luck bout water1.00Myrrh resin extract3.003.003.00Sea grape extract2.802.802.80Oak moss extract3.003.003.00Green tea extract2.002.002.00