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KR-20260063479-A - A cosmetic composition comprising Eclipta prostrata L. extracts for promoting skin beneficial bacteria

KR20260063479AKR 20260063479 AKR20260063479 AKR 20260063479AKR-20260063479-A

Abstract

The present invention relates to a composition for promoting beneficial skin bacteria comprising a nasturtium extract. The composition according to the present invention promotes or enhances the growth of beneficial skin bacteria, such as Staphylococcus epidermidis and Staphylococcus hominis, and does not promote or inhibits the growth of harmful skin bacteria, such as Staphylococcus aureus.

Inventors

  • 송경희
  • 이홍구

Assignees

  • 주식회사 엘지생활건강

Dates

Publication Date
20260507
Application Date
20241030

Claims (14)

  1. A composition for promoting beneficial skin bacteria comprising an extract of *Eclipta prostrata L.* or a fraction thereof as an active ingredient.
  2. In paragraph 1, The above skin beneficial bacteria is a composition comprising one or more selected from the group consisting of Staphylococcus epidermidis and Staphylococcus hominis.
  3. In paragraph 1, The above composition is a composition that does not promote or inhibits the growth of harmful skin bacteria.
  4. In Paragraph 3, A composition in which the above-mentioned skin harmful bacteria is Staphylococcus aureus.
  5. In paragraph 1, The above extract is a composition in which the extract is an extract of one or more solvents selected from the group consisting of water and C1-C4 alcohols.
  6. In paragraph 5, The above solvent is a composition in which the solvent is an aqueous solution of butylene glycol in an amount of 50 to 100 weight%.
  7. In paragraph 1, A composition in which the above-mentioned *Hallyeocho* extract is included in an amount of 0.00001 to 2 weight% based on the total weight of the composition.
  8. A cosmetic composition comprising the composition according to claim 1.
  9. A method for preparing a composition for promoting beneficial skin bacteria, comprising the step of extracting a *Hallyeocho* extract using a solvent.
  10. In Paragraph 9, The above extraction is a manufacturing method in which the ratio of raw *Hallyeocho* material to solvent is 1:10 to 1:30.
  11. In Paragraph 9, The above extraction is a manufacturing method performed at 70 to 90°C.
  12. In Paragraph 9, A manufacturing method in which the above extraction is performed for 4 to 10 hours.
  13. In Paragraph 9, A method of preparation in which the solvent is one or more selected from the group consisting of water and C1-C4 alcohols.
  14. In Paragraph 13, A method of preparation in which the solvent is an aqueous solution of butylene glycol in an amount of 50 to 100 weight%.

Description

A cosmetic composition comprising Eclipta prostrata L. extracts for promoting skin beneficial bacteria The present invention relates to a composition for promoting beneficial skin bacteria comprising a nasturtium extract. The proper functioning of the skin barrier is essential for human health. Keratinocytes in the stratum corneum, a component of the skin barrier, play a crucial role in the body's overall adaptation by producing hormones, neurotransmitters, and cytokines in response to changes in the external environment. In performing these functions, skin microorganisms aid in the maturation of keratinocytes and influence the regulation of the body's overall immune system. Therefore, changes in the skin microbiome can lead not only to skin diseases but also to other inflammatory conditions (non-communicable diseases, NCDs). In fact, microbial disturbances in the stratum corneum are known to be associated with skin allergies, psoriasis, rosacea, acne, and skin aging. The four main bacterial strains inhabiting human skin are Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. However, even within a single individual, the composition of skin microorganisms varies significantly depending on the environment. For instance, oily areas are home to a high abundance of Propionibacteria and Staphylococci species, moist areas to Corynebacteria and Staphylococci, and dry areas to primarily inhabit with various species, including beta-Proteobacteria and Flavobacteriale. As such, the bacterial strains inhabiting the skin differ from person to person and can vary depending on individual nutritional status, health, age, and surrounding environment. Among these, Staphylococcus epidermidis constitutes more than 90% of the aerobic environment. This bacterium can exert effects such as alleviating inflammation by regulating the FFAR2 (Free fatty acid receptor 2) mechanism to suppress cytokine enhancement caused by UVB (Non-patent Literature 0001), regulating psoriasis-related inflammation by regulating the expression of A20, an inflammation-regulating protein in the host (Non-patent Literature 0002), and inhibiting tumor growth by selectively inhibiting DNA polymerase activity in tumor cells (Non-patent Literature 0003). Additionally, it can help with immune function by strengthening the skin barrier through the expression of tight junction proteins. In addition, it is known that Staphylococcus hominis, a skin symbiont, can reduce the likelihood of atopic dermatitis (Non-patent Literature 0004) and protect the skin against external pathogens (harmful bacteria) by producing antibiotics through specific chemical action (Non-patent Literature 0005). Therefore, as with other organs, the skin's innate immune system can be said to be formed through the interaction between humans and microorganisms, and this can be considered an important factor in controlling the homeostasis of skin immunity. Accordingly, since skin condition can be improved if the growth of Staphylococcus epidermidis and Staphylococcus hominis, which are beneficial bacteria that are commensal to the skin, is promoted, there is an increasing demand for the development of substances that can exhibit such beneficial bacteria-promoting effects as cosmetic ingredients. Against this backdrop, the inventors made diligent efforts to develop a composition that promotes beneficial skin bacteria such as Staphylococcus epidermidis and Staphylococcus hominis, and as a result, identified a natural product with a beneficial skin bacteria promoting effect, thereby completing the present invention. Figure 1 is a graph confirming the skin bacteria growth-promoting effect at a concentration of 0.01% of the *Hallyeocho* extract of the present invention. Figure 2 is a graph confirming the skin bacteria growth-promoting effect at a concentration of 0.1% of the nasturtium extract of the present invention. Figure 3 is a graph confirming the skin bacteria growth-promoting effect according to the concentration of the nasturtium extract of the present invention. The present invention will be described in detail below. The present invention provides a composition for promoting beneficial skin bacteria comprising an extract of *Eclipta prostrata L.* or a fraction thereof as an active ingredient. In the present invention, "Eclipta prostrata L." is a perennial plant that grows naturally in moist areas such as rice paddy ridges and stream banks in the central and southern regions of Korea, and is also known as Aejangcho, Mokhallyeon, Mukducho, Haryeon, Haryeoncho, and Hannyeonpul. It has been known since ancient times to be effective for promoting blood flow, pain relief, immunity, dermatitis, promoting hair growth, and skin cracking. It is known that the above-mentioned Eclipta prostrata contains saponins, tannins, bitter substances, ecliptin (Eclipta prostrata extract), vitamin A substances, nicotine, and coumarin compounds such as wedelolactone and demethylwedelolactone-7-glucosid.