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KR-20260063826-A - Anti-inflammatory composition containing onion peel extract as an active ingredient

KR20260063826AKR 20260063826 AKR20260063826 AKR 20260063826AKR-20260063826-A

Abstract

The present invention is an anti-inflammatory composition comprising onion peel extract as an active ingredient, which can exhibit excellent anti-inflammatory effects by inhibiting nitric oxide and inducible nitric oxide enzymes, and directly inhibiting inflammation-inducing cytokines and JAK-STAT signaling.

Inventors

  • 예상규
  • 권용진
  • 이현승
  • 서은비
  • 김슬기
  • 강채명

Assignees

  • 서울대학교산학협력단

Dates

Publication Date
20260507
Application Date
20241031

Claims (7)

  1. Containing onion (Allium cepa L., A. cepa) peel extract as an active ingredient Anti-inflammatory composition.
  2. In paragraph 1, The above extract is extracted with one or more solvents selected from the group consisting of lower alcohols having 1 to 4 carbon atoms, ethyl acetate, acetone, water, and hexane. Anti-inflammatory composition.
  3. A composition for anti-inflammatory purposes according to claim 1 or 2 Pharmaceutical composition for the prevention or treatment of inflammatory diseases.
  4. In paragraph 3, The above inflammatory disease is characterized by being one or more diseases selected from the group consisting of inflammatory bowel disease, non-alcoholic chronic hepatitis, chronic hepatitis, Crohn's disease, pancreatitis, esophagitis, gastritis, colitis, ulcerative colitis, pneumonia, bronchitis, pharyngitis, myocardial infarction, heart failure, arthritis, psoriatic arthritis, rheumatoid arthritis, renal failure, psoriasis, anemia, diabetes, fibrosis, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis, asthma, chronic obstructive pulmonary disease, periodontitis, neuropathic pain, and idiopathic inflammatory myopathy. A pharmaceutical composition for preventing or treating inflammatory diseases.
  5. A composition for anti-inflammatory purposes according to claim 1 or 2 Anti-inflammatory topical skin preparation composition.
  6. A composition for anti-inflammatory purposes according to claim 1 or 2 Food composition for anti-inflammatory purposes.
  7. A composition for anti-inflammatory purposes according to claim 1 or 2 Cosmetic composition for anti-inflammatory purposes.

Description

Anti-inflammatory composition containing onion peel extract as an active ingredient The present invention relates to an anti-inflammatory composition comprising onion peel extract as an active ingredient. Inflammation is the body's defense response to infection by external infectious agents, such as external physical and chemical stimuli, bacteria, fungi, viruses, and various allergens. Inflammatory response is part of the innate immune response, and as in other animals, the human innate immune response is initiated when macrophages recognize pathogens as non-self through cell surface patterns specifically present on them and attack them. During an inflammatory response, plasma accumulates at the site of inflammation to dilute the toxins secreted by bacteria, blood flow increases, and symptoms such as erythema, pain, edema, and fever occur. Various biochemical phenomena are involved in these inflammatory responses, and in particular, nitric oxide synthase (NOS) and cyclooxygenase (COX), which is involved in the biosynthesis of various prostaglandins, are known as important mediators of the inflammatory response. NOS exists in three isomers: eNOS (endothelial NOS) and nNOS (neurogenic NOS), which are calcium or camodulin-dependent; and iNOS (inducible NOS), which is induced by bacterial endotoxins such as LPS (lipopolysaccharide) or various inflammatory cytokines such as IL-1β, TNF-α, IL-6, IL-8, and IL-12, and it produces nitric oxide (NO) from L-arginine. NO generated by eNOS or nNOS plays an important role in maintaining homeostasis in the human body by performing various physiological reactions related to blood pressure regulation, neurotransmission, learning, and memory, but NO generated by iNOS is known to be involved in various inflammatory diseases such as arthritis, sepsis, tissue transplant rejection, autoimmune diseases, and neuronal cell death (Moncade S. et al, Pharmacol. Rev., 1991, 43, 109; Nature Medicine, 2001, 7, 1138; Mu, M. M., J. Endotoxic Res. 7, p341, 2001). Along with the function of COX, COX enzymes possess hydroperoxidase (HOX) activity and synthesize the intermediates PGG2 and PGH2 from arachidonic acid, producing PGE2 , PGF2 , PGD2 , prostacyclin, and thromboxane A2 ( TxA2 ). Among the functions of COX , the function of PGH synthase is involved in pain and inflammatory responses through the synthesis of PGE2 . There are two subtypes of COX, and while COX-1 is congenitally expressed in most tissues, COX-2 is rapidly induced by inflammatory cytokines and plays an important role in the inflammatory response. Therefore, inhibitors of NO, PGE2, inflammatory cytokines, iNOS inhibitors, and COX-2 inhibitors can be utilized as treatments for inflammatory diseases. In particular, there is a need to develop products using natural materials that do not cause side effects even with long-term use and can exhibit excellent anti-inflammatory effects. Figure 1 shows the total amount of flavonoids, antioxidant activity, and HPLC analysis results of an onion peel extract according to one embodiment of the present invention. Figure 2 is a test result confirming whether LPS-induced inflammation in RAW 264.7 is inhibited using an onion peel extract according to one embodiment of the present invention. Figure 3 is the test result regarding whether the onion peel extract according to one embodiment of the present invention inhibits IL-1β and IL-6 production and JAK-STAT activation in LPS-induced RAW264.7. Figure 4 is the test result regarding whether an onion peel extract according to one embodiment of the present invention inhibits inflammatory IL-1α and IL-27 in LPS-induced RAW264.7. Figure 5 is a test result regarding whether the onion peel extract according to one embodiment of the present invention directly blocks the JAK-STAT axis. Figure 6 is a summary result of the study of the onion peel extract according to one embodiment of the present invention. Hereinafter, embodiments of the present invention are described in detail so that those skilled in the art can easily implement the invention. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. Inflammation is an important defense mechanism of an organism against harmful stimuli such as pathogens and irritants (Chen et al., 2018). Acute and regulated inflammation is a protective immune response that eliminates harmful external stimuli, promotes healing, and maintains homeostasis of tissues and organs (Soliman and Barreda, 2023). However, persistent and uncontrolled inflammation can lead to chronic diseases such as cardiovascular disease, rheumatoid arthritis, autoimmune diseases, neurological diseases, and cancer (Suzuki, 2019). Therefore, it is important to identify therapeutic strategies that suppress excessive inflammatory responses. Macrophages differentiate from blood monocytes and play a protective role in inflammatory responses (Han et al., 2021). Toll-like receptor