KR-20260063847-A - AI Health Management System through Oral Multi-Omics Based Liquidome Analysis: Simplified Conversion and Explanation to Biological Age

KR20260063847AKR 20260063847 AKR20260063847 AKR 20260063847AKR-20260063847-A

Abstract

The present invention relates to an AI health management system based on oral multi-omics-based body fluid analysis, providing an innovative method for precisely evaluating an individual's health status and calculating biological aging age. The system is based on an oral multi-omics analyzer comprising a compact point-of-care genome sequencing device and omics analysis equipment to analyze samples collected from the oral cavity. Users collect samples by spitting or rinsing their mouths, and DNA, RNA, proteins, and meta-omics data from these samples are decoded to analyze the state of the oral host and microorganisms. The collected data is analyzed in real-time by AI algorithms to assess health status and calculate and provide the biological aging age to the user. The present invention supports health improvement by explaining analysis results in a manner easy for users to understand and by suggesting personalized health management methods and dietary regimens. In addition, it strengthens data integrity and security by establishing a decentralized blockchain platform for securely storing and managing individual fluid omics data. Changes in health status are continuously monitored through periodic sample submissions, and the AI model continuously learns and improves using user data. User guides and customer support services facilitate the smooth use of the system, and regular feedback is collected to enhance the user experience. These components demonstrate that the present invention presents a new paradigm for personalized healthcare solutions and contributes to helping users effectively manage their health. The present invention provides an innovative approach in the field of healthcare and is expected to contribute to the future development of medical and healthcare systems.

Inventors

박종화
조수안
전성원

Assignees

주식회사 제로믹스
에이징랩 주식회사
울산과학기술원

Dates

Publication Date: 20260507
Application Date: 20241031

Claims (8)

As an AI health management system through oral multi-omics-based body fluid analysis, An oral multi-omics analyzer including a small genome sequencing device and omics analysis equipment for analyzing samples collected from the oral cavity; AI analysis module for real-time analysis of collected gene, protein, metagene, and metabolite data; An AI health management system including a user interface that simplifies the explanation of biological aging age and visualizes the results.
In paragraph 1, It includes a sample collection unit that collects a sample through spitting or oral rinsing by the user in the mouth, and An AI healthcare system comprising a genome sequencing machine that analyzes the state of the oral host and microorganisms by decoding DNA, RNA, protein, and metaomics data from collected samples.
In paragraph 2, By applying AI models to analyze collected omics data and evaluate health status, An AI health management system that calculates biological aging age based on analysis results and utilizes it as an indicator.
In paragraph 3, Explain to the user the analysis results of the above omics data to which the above AI model was applied, and An AI healthcare system that suggests personalized health management and dietary plans.
In paragraph 4, It includes a decentralized blockchain platform for securely storing and managing individual fluid omics data, and An AI healthcare system that performs a more precise health status assessment by integrally analyzing omics data of hosts and microorganisms.
In paragraph 5, Users regularly submit samples to monitor changes in health status, An AI health management system that continuously trains and improves the above AI model using user data.
In paragraph 6, It includes a user guide that provides educational materials on how to use the above-mentioned health management system and health management, and An AI healthcare system that provides customer support services to resolve user questions or problems.
In Paragraph 7, Periodically update the analysis results for samples submitted by users, and An AI health management system that continuously monitors changes in a user's health status and provides personalized health management.

Description

AI Health Management System through Oral Multi-Omics Based Liquidome Analysis: Simplified Conversion and Explanation to Biological Age The present invention relates to a system that produces a liquidome using a decoder for decoding various gene-related omics sequences and utilizes AI to simultaneously and correlately analyze omics information of a host and microorganism simply by spitting out saliva from the mouth. This system expresses the health status of humans and animals in real time using a simple and consistent index (indicator) called gero age (or biological age), and provides an interface where AI easily explains this, thereby implementing an AI-based health precision liquidomes measurement system that is easy for users to understand and accurate. While a balance is maintained during good health, various diseases cause imbalances in the interactions between the host and microorganisms. Consequently, there is an increasing demand for healthcare devices capable of predicting disease-related biological aging age by measuring the most effective indicators among the host's gene-related omics data and microbial omics data within the oral cavity. Thousands of types of microorganisms coexist with host omics data (e.g., DNA, RNA, protein sequences, epigenome sequences, etc.) within the oral cavity. If host omics data alone is sufficient to determine health status and biological age, and if the cost is low, this would be highly useful. In the human mouth, human epithelial cells, immune cells in saliva, and thousands of types of bacteria, viruses, fungi, and protozoa exist within the oral saliva. Since 1995, the inventors have defined all liquid and cell-based omics data, including omics data and microorganisms within the oral cavity of a host—particularly humans and animals—as the "liquidome." Since 2020, driven by the rapid advancement of new omics decoding technologies, it has become possible to precisely analyze multi-omics-based liquidome information through bioinformatics. Furthermore, recent advancements in generative massive language models such as ChatGPT have made it realistically possible to build health information management systems that combine fluid dynamics and AI. Recently, it has become easier to express all health conditions in terms of biological age in a powerful and convenient manner. Consequently, it has become possible to create a simple and intuitive biological age-based health measurement and management system by combining the three elements of fluid dynamics, biological age, and AI. The present invention aims to develop a comprehensive program that integrates these elements to securely build AI-analyzed host omics-based body fluids onto a simple web and app-based decentralized blockchain platform, thereby enabling users to easily manage omics data. A key feature of this system is that it not only allows for the determination of biological aging age using only host omics data but also provides the optional capability to comprehensively analyze microbial omics data. This microbial information is also helpful in measuring rapid changes in biological age caused by infectious diseases such as COVID-19 and influenza. Registered Patent Publication No. 10-2179850 relates to a health prediction system and method using an oral microorganism analysis device, and discloses features including collecting a sample from a subject, feeding it into a genome sequencing device capable of on-site testing, performing genome sequencing or examination to identify the genetic species of microorganisms obtained through oral rinsing, brushing, or gargling, and processing software utilizing the findings, analysis, and subsequent measures. However, such simple, microorganism-based methods cannot accurately measure the overall health of humans and animals. Furthermore, because indicators are highly variable due to daily or weekly changes in diet and health status, it is essential to incorporate host omics data to develop higher-level, highly precise biological aging-based indicators. This invention aims to overcome the limitations of decades of various fragmentary patents and technologies by integrating AI, body fluid data, host-microorganism interactions, and biological aging. FIG. 1 schematically illustrates the oral microbiome analysis system of the present invention. The following description of the present invention with reference to the drawings is not limited to specific embodiments and may be subject to various modifications and have various embodiments. Furthermore, it should be understood that the content described below includes all modifications, equivalents, and substitutions that fall within the spirit and scope of the present invention. In the following description, terms such as "first," "second," etc., are used to describe various components and are not limited in their meaning; they are used solely for the purpose of distinguishing one component from another. Identical reference numbers used th