KR-20260064035-A - Composition for reducing dentin hypersensitivity and method for preparing the same

Abstract

The present invention relates to an oral composition for improving dentin hypersensitivity comprising a zinc salt, a potassium salt, and a milk protein hydrolysate, and a method for preparing the same. The composition according to the present invention inhibits the formation of insoluble metal salts through the stabilization of the zinc salt and potassium salt, and has an excellent dentinal tubule blocking effect, so it can be effectively used in an oral composition for improving dentin hypersensitivity.

Inventors

• 임종현
• 문교태
• 오경희

Assignees

• 주식회사 엘지생활건강

Dates

Publication Date

20260507

Application Date

20241031

Claims (16)

1. Oral composition for improving dentin hypersensitivity comprising zinc salt, milk protein hydrolysate, and potassium salt.
2. In paragraph 1, An oral composition in which the zinc salt is one or more selected from the group consisting of zinc chloride (ZnCl₂), zinc nitrate (Zn(NO₃)₂), zinc sulfate (ZnSO₄), zinc acetate (Zn(CH₃CO₂)₂ ) , zinc carbonate ( ZnCO₃ ) , zinc fluoride (ZnF₂), and zinc hydroxide (Zn(OH) ₂ ).
3. In paragraph 1, An oral composition comprising 0.01 to 0.2 weight percent of the zinc salt based on the total weight of the oral composition.
4. In paragraph 1, An oral composition in which the potassium salt is one or more selected from the group consisting of monopotassium phosphate ( KH₂PO₄ ), dipotassium phosphate ( K₂HPO₄ ), tripotassium phosphate ( KH₃PO₄ ), potassium nitrate ( KNO₃ ), potassium chloride ( KCl ), and potassium oxalate (K₂C₂O₄ ) .
5. In paragraph 1, An oral composition comprising 1 to 10 weight percent of the potassium salt based on the total weight of the oral composition.
6. In paragraph 1, An oral composition comprising 0.01 to 2 weight percent of the above milk protein hydrolysate based on the total weight of the oral composition.
7. A food composition for improving dentin hypersensitivity comprising an oral composition according to any one of claims 1 to 6.
8. A pharmaceutical composition for the prevention or treatment of dentin hypersensitivity comprising an oral composition according to any one of claims 1 to 6.
9. A first step of mixing zinc salt, milk protein hydrolysate, and purified water; and A method for preparing an oral composition for improving dentin hypersensitivity, comprising: a second step of additionally mixing a potassium salt after the first step above.
10. In Paragraph 9, A method in which the zinc salt is one or more selected from the group consisting of zinc chloride (ZnCl₂), zinc nitrate (Zn(NO₃)₂), zinc sulfate (ZnSO₄), zinc acetate (Zn(CH₃CO₂)₂ ) , zinc carbonate ( ZnCO₃ ), zinc fluoride ( ZnF₂ ), and zinc hydroxide (Zn(OH) ₂ ).
11. In Paragraph 9, A method comprising 0.01 to 0.2 weight percent of the zinc salt based on the total weight of the oral composition.
12. In Paragraph 9, A method in which the potassium salt is one or more selected from the group consisting of monopotassium phosphate ( KH₂PO₄ ), dipotassium phosphate ( K₂HPO₄ ), tripotassium phosphate ( KH₃PO₄ ), potassium nitrate ( KNO₃ ), potassium chloride ( KCl ), and potassium oxalate ( K₂C₂O₄ ) .
13. In Paragraph 9, A method comprising 1 to 10 weight percent of the potassium salt based on the total weight of the oral composition.
14. In Paragraph 9, A method comprising 0.01 to 2 weight percent of the milk protein hydrolysate based on the total weight of the oral composition.
15. In Paragraph 9, A method in which the above oral composition comprises a zinc salt-milk protein hydrolysate-potassium salt complex.
16. In paragraph 15, A method in which the particle diameter of the above-mentioned composite is 500 to 600 nm.

Description

Oral composition for improving dentin hypersensitivity and method for preparing the same The present invention relates to an oral composition for improving dentin hypersensitivity comprising a zinc salt, a potassium salt, and a milk protein hydrolysate, and a method for preparing the same. More specifically, the invention relates to an oral composition in which the zinc salt, a potassium salt, and a milk protein hydrolysate form a complex within the formulation to improve stability and exhibit excellent efficacy in improving dentin hypersensitivity, and a method for preparing the same. The dentin of the tooth contains dentinal tubules, which are thin tubes filled with dentinal fluid. Inside the dentinal tubules, dentinblasts and nerve cells are present. However, when the enamel covering the dentin is lost due to various reasons such as aging or disease, exposing the dentinal tubules, the flow of the dentinal fluid changes. This stimulates the nerve sensations of the tooth, causing discomfort and pain; this condition is referred to as dentin hypersensitivity. In the case of oral compositions for improving such dentin hypersensitivity, divalent metal ions such as Sn²⁺ , Zn²⁺ , and Sr²⁺ , or potassium salts such as potassium nitrate and potassium phosphate, are mainly used as active ingredients. These ingredients are known to have an effect of blocking dentinal tubules, and oral compositions for improving dentin hypersensitivity containing divalent metal ions and potassium salts as active ingredients exist. However, although divalent metal ions and potassium salts each have excellent effects in improving dentin hypersensitivity, there is a problem in that the two components react in an aqueous solution and form insoluble metal salts when included together in a formulation, which reduces the effect of improving dentin hypersensitivity. Against this background, the inventors developed an oral composition containing zinc salt and potassium salt, which are divalent metal ions, and which can suppress the formation of insoluble metal salts through the stabilization of the two components. They confirmed that this composition not only further enhances the dentinal tubule sealing effect but also has excellent resistance to acid, thereby completing the present invention. Figure 1 is a photograph showing the dispersion and precipitate of a composition according to a combination of zinc chloride, potassium phosphate, and milk protein hydrolysate according to one embodiment of the present invention. Figure 2 is a photograph showing the dispersion and precipitate according to the mixing order of a composition comprising zinc chloride, potassium phosphate, and milk protein hydrolysate, according to one embodiment of the present invention. FIG. 3 is a graph showing the average particle diameter of a composition comprising zinc chloride, potassium phosphate, and milk protein hydrolysate according to one embodiment of the present invention. FIG. 4 is a schematic diagram of particles present in each composition comprising zinc chloride, potassium phosphate, and milk protein hydrolysate according to one embodiment of the present invention. FIG. 5 is a schematic diagram of particles present when a composition comprising zinc chloride, potassium phosphate, and milk protein hydrolysate comes into contact with hydroxyapatite powder, according to one embodiment of the present invention. Figure 6 is a photograph showing the exposed dentinal tubule surface before and after repeated treatment of a dentin specimen with the composition of Example 5 prepared according to one embodiment of the present invention. Figure 7 is a photograph showing the surface of the exposed dentinal tubules before and after repeated treatment and acid exposure to a dentin specimen with the composition of Example 5 prepared according to one embodiment of the present invention. The present application will be explained in more detail below through examples. However, the following examples are merely preferred embodiments for illustrating the present application and are therefore not intended to limit the scope of the rights of the present application. Meanwhile, technical matters not described in this specification can be sufficiently understood and easily implemented by a person skilled in the art who is proficient in the technical field of the present application or a similar technical field. The drawings and embodiments of this specification are intended to enable a person skilled in the art to easily understand and practice the invention. Content that may obscure the essence of the invention may be omitted from the drawings and embodiments, and the invention is not limited to the drawings and embodiments. Throughout this specification, "%" used to indicate the concentration of a particular substance is (weight/weight)% for solid/solid, (weight/volume)% for solid/liquid, and (volume/volume)% for liquid/liquid, unless otherwise noted. Unless otherwise specified