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KR-20260064281-A - Neural probe with internal passage formed

KR20260064281AKR 20260064281 AKR20260064281 AKR 20260064281AKR-20260064281-A

Abstract

The present invention relates to a neural probe having an internal passage, and more specifically, to a neural probe comprising a sensing part and a connector connection part, wherein a fluid path or optical waveguide is formed internally from the sensing part to the connector connection part, and the fluid path or optical waveguide is closed at the sensing part. The neural probe of the present invention can directly inject a drug solution, be used as a light path, or directly perform photostimulation; thus, it is expected to have the effect of enabling the precise selection of the drug solution injection site, light irradiation site, or photostimulation site, and the execution of these measures at the precise timing.

Inventors

  • 김형준

Assignees

  • 하이비스 주식회사

Dates

Publication Date
20260507
Application Date
20241031

Claims (5)

  1. A neural probe comprising a sensing unit; and a connector connection unit, A fluid path or optical waveguide is formed internally from the above-mentioned sensing part to the connector connection part, and A neural probe having an internal passage formed such that the above-mentioned Euro or optical waveguide is closed as a hole at the sensing part.
  2. In paragraph 1, The above-described neural probe having an internal passage formed therein, characterized in that a drug is injected from the connector connection part or from the outside of the connector connection part and discharged through a hole provided in the sensing part via the passage of the connector connection part and the sensing part.
  3. In paragraph 1, The above optical waveguide is a neural probe having an internal passage formed therein, characterized in that a medium is injected from the connector connection part or from the outside of the connector connection part, passes through the passage of the connector connection part and the sensing part, and extends to a hole provided in the sensing part.
  4. In paragraph 3, A neural probe having an internal passage formed, characterized in that the above medium solidifies within an optical waveguide.
  5. In paragraph 1, A neural probe having an internal passage formed therein, characterized in that the above-mentioned Euro and optical waveguide are installed separately, and each end is formed to be connected to a hole individually provided in the sensing part.

Description

Neural probe with internal passage formed The present invention relates to a neural probe having an internal passage formed therein. The neural probe of the present invention has a passage formed therein, and through this passage, it is possible to directly inject a drug solution, use it as a light path, or directly perform photostimulation. Through this, the location for drug solution injection, light irradiation, or photostimulation can be accurately selected, and these measures can be performed at an accurate timing. Neural probes are electrodes that penetrate the brain to transmit or receive electrical signals; while they come in various shapes, circular shapes are most commonly used. As illustrated in FIG. 1, circular electrodes are formed on a neural probe in a specific arrangement (here, a rhombus arrangement). The diameter of a single circular electrode is approximately 15 to 25 μm. Because these neural probes require separate injection or the insertion of additional optical fibers to provide light stimulation when administering drugs, it is difficult to analyze the precise location and timing in conjunction. Therefore, there has been a demand for the development of new neural probes that can resolve these difficulties. Figure 1 is a diagram showing a neural probe. FIG. 2 is a drawing showing a plan view and a cross-sectional view of a neural probe according to one embodiment of the present invention. FIG. 3 is a drawing showing a plan view and a cross-sectional view of an internal passage of a neural probe according to one embodiment of the present invention. Hereinafter, embodiments of the present invention are described in detail with reference to the attached drawings so that those skilled in the art can easily implement the invention. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. Furthermore, in order to clearly explain the present invention in the drawings, parts unrelated to the explanation have been omitted, and similar parts throughout the specification are denoted by similar reference numerals. Throughout the specification, when a part is described as "including" a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components. In addition, terms such as "…part," "…unit," etc., as described in the specification refer to a unit that processes at least one function or operation. FIG. 1 is a drawing showing a neural probe, FIG. 2 is a drawing showing a plan view and a cross-sectional view of a neural probe according to an embodiment of the present invention, and FIG. 3 is a drawing showing a plan view and a cross-sectional view of a neural probe according to an embodiment of the present invention in a state where the internal passage is processed. As illustrated in FIG. 3, the neural probe (100) having an internal passage formed according to the present invention comprises a sensing part (110) and a connector connection part (120). A path or optical waveguide (130) is formed internally from the sensing part (110) to the connector connection part (120), and the path or optical waveguide (130) is closed at the sensing part (110) with a hole (140). The path or optical waveguide (130) is an internal passage and is formed inside the neural probe (100), so it cannot be observed from the outside except for the hole (140). The above Euro or optical waveguide (130) can be formed, for example, by processing a neural probe (100) with a laser. However, the processing method is not necessarily limited to a laser. The above internal passage has two ends formed at the sensing part (110) and the connector connection part (120), respectively. The end formed at the connector connection part (120) is the input direction, and the end formed at the sensing part (110) is the output direction as a hole (140). For example, a syringe can be connected to the end formed at the connector connection part (120) or to the outside connected to the above end to inject a liquid medicine or water, or an optical fiber can be connected to perform photostimulation or light irradiation. However, through the passage, not only liquid medicine is injected, but fine devices can also be inserted. Examples of such liquid medicines include cell activation solutions, biological solutions, anti-inflammatory agents, etc., and cells can also be activated by light. The above-mentioned path is formed by injecting a drug from, for example, the end of the connector part (120) or from an external (not shown) connected to the connector part (120) and discharging it through a hole (140) provided in the sensing part (110). In the case of an optical waveguide, the medium for forming the optical path may be filled with, for example, a transparent material that solidifies after being injected into the optical waveguide. In this case, the medium may be injected from, for example, the en