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KR-20260064648-A - BIO-PRINTING DEVICE

KR20260064648AKR 20260064648 AKR20260064648 AKR 20260064648AKR-20260064648-A

Abstract

The bioprinting device of the present invention comprises: a transport case including a case wall extending downward from the top and connected to the bottom, and a case hollow formed in the case wall; a plurality of guide segments located in the case hollow, coupled to the case wall, and spaced apart from each other; and a nozzle module provided at the bottom of the case wall, wherein the case wall includes a front case wall forming the front face of the transport case; and a rear case wall forming the rear face of the transport case, and each of the plurality of guide segments may include a front guide end connected to the front case wall; a rear guide end connected to the rear case wall; and a guide body extending backward from the electrode guide end and connected to the rear guide end.

Inventors

  • 하동헌

Assignees

  • 주식회사 에드믹바이오

Dates

Publication Date
20260507
Application Date
20251113
Priority Date
20241031

Claims (12)

  1. A transport case comprising a case wall extending from the top downward and continuing to the bottom, and a case hollow formed in the case wall; A plurality of guide segments located in the hollow portion of the case, coupled to the case wall, and spaced apart from each other; and It includes a nozzle module provided at the bottom of the above case wall, and The above case wall is, A front case wall forming the front face of the above transport case; and It includes a rear case wall forming the rear of the above transport case, and Each of the above plurality of guide segments is, A front guide end connected to the front case wall; A rear guide end connected to the rear case wall above; and A guide body including a guide body that extends backward from the electrode guide end and connects to the rear guide end. Bioprinting device.
  2. In paragraph 1, Each of the above plurality of guide segments is, Forming the shape of a pillar, Bioprinting device.
  3. In paragraph 2, Each of the above plurality of guide segments is, Forming the shape of a cylinder, Bioprinting device.
  4. In paragraph 1, The above guide body protrudes upward and protrudes downward, Bioprinting device.
  5. In paragraph 4, The height at which the lower portion of the above guide body protrudes downward is The upper portion of the guide body is greater than the height at which it protrudes upward, Bioprinting device.
  6. In paragraph 1, The thickness of the above guide body is, Larger than the thickness of the front guide end and larger than the thickness of the rear guide end, Bioprinting device.
  7. In paragraph 1, The above case wall is, A top case wall further comprising a top case wall that forms the upper surface of the above transport case, wherein a top case wall opening is formed, and is connected to the front case wall and the rear case wall. Bioprinting device.
  8. In Paragraph 7, A transport tube further comprising a top case wall coupled thereto and extending downward from the top case wall opening, Bioprinting device.
  9. In paragraph 8, The above plurality of guide segments are, Symmetrically arranged with respect to the above transport tube, Bioprinting device.
  10. In paragraph 8, The above case wall is, A first side case wall that extends backward from the front case wall and connects to the rear case, forming a first side of the transport case; It further includes a second side case wall that extends backward from the front case wall and connects to the rear case, forming a second side of the transport case. Some of the above plurality of guide segments are, Located between the first side case wall and the transport tube, Another part of the above plurality of guide segments is, Located between the second side case wall and the transport tube, Bioprinting device.
  11. In paragraph 8, A front case wall opening penetrating the front case wall from front to back is formed in the front case wall, Bioprinting device.
  12. In paragraph 8, The bottom of the nozzle module and the bottom of the transport tube are located on the same plane. Bioprinting device.

Description

Bio-printing device The present invention relates to a bioprinting device. 3D printing, which can bring innovation to manufacturing methods, is attracting attention as one of the promising technologies leading the Fourth Industrial Revolution, and related research is being actively conducted in various fields. Interest in 3D bioprinting for the production of artificial tissues and organs is also growing in the bio/medical field. 3D bioprinting is a concept that combines 3D printing technology with biotechnology. For example, tissues and organs can be produced by stacking living cells into a desired shape using 3D bioprinting. While the basic printing method is the same as general 3D printing, the difference is that 3D bioprinting uses biocompatible polymers, biomaterials, etc., as basic materials to print living cells. There are 3D bioprinting techniques such as the inkjet method, which prints by spraying material in small droplets; the micro-extrusion method, which pushes material with a viscosity of a certain level or higher using pneumatic pressure or a piston; and the photolithography method, which irradiates a light source onto the surface of a photocurable resin. Regarding 3D bioprinting technology, KR 10-2021-0099013 A (Patent Document 1) discloses a 'print head assembly for a 3D bioprinter,' and KR 10-1805774 B (Patent Document 2) discloses a 'three-dimensional bioprinting device and a three-dimensional bioprinting method using the same.' However, Patent Documents 1 and 2 fail to improve the chronic problem in 3D bioprinting, namely, slow printing speed. US 2002-0401218 A (Patent Document 3) describes a 3D bioprinting technology capable of surface printing. Surface printing can have the effect of improving printing speed. However, in the case of surface printing, there is a problem in that the printing quality deteriorates because the ejection speed of the bio-ink varies depending on the location. FIG. 1 is a drawing showing a bioprinting device according to one embodiment of the present invention. Figure 2 is a drawing showing the state in which the front case wall and nozzle have been removed from the bioprinting device illustrated in Figure 1. FIG. 3 is a drawing showing a guide segment according to one embodiment of the present invention. Figure 4 is a cross-sectional view of Figure 3. Figure 5 is a drawing showing the case where the guide body illustrated in Figure 4 has a convex shape. FIG. 6 is a cross-section of the guide segment shown in FIG. 5, showing that the lower part of the guide body protrudes more than the upper part of the guide body. Figure 7 is a plan view of the bioprinting device illustrated in Figure 1, showing the state in which a guide segment is combined with a transport case. Figure 8 is a cross-sectional view of the bioprinting device illustrated in Figure 7, cut along A1-A2. Figure 9 is a diagram showing the state in which the water density of the guide segments becomes higher as it goes down, as shown in the bioprinting device illustrated in Figure 8. Figure 10 is a drawing showing a transport tube added to the transport module shown in Figure 2. Figure 11 is a drawing showing an opening formed in the front case wall illustrated in Figure 1. FIG. 12 is a cross-sectional view of the bioprinting device cut along A1-A2 with a transport tube added to the bioprinting device illustrated in FIG. 7. FIG. 13a is a drawing showing living cells among the cells contained in the liquid transported through the bioprinting device shown in FIG. 8. FIG. 13b is a diagram showing dead cells among the cells contained in the liquid transported through the bioprinting device shown in FIG. 8. FIG. 14a is a drawing showing living cells among the cells contained in the liquid transported through the bioprinting device shown in FIG. 9. FIG. 14b is a diagram showing dead cells among the cells contained in the liquid transported through the bioprinting device shown in FIG. 9. FIG. 15a is a drawing showing living cells among the cells contained in the liquid transported through the bioprinting device shown in FIG. 2. FIG. 15b is a diagram showing dead cells among the cells contained in the liquid transported through the bioprinting device shown in FIG. 2. FIG. 16a is a diagram showing the appearance at a certain point in time during a simulation process of liquid transport through a bioprinting device according to one embodiment of the present invention. FIG. 16b is a diagram showing the appearance at a certain point in time during the simulation process of liquid transport through the bioprinting device illustrated in FIG. 10. Hereinafter, embodiments disclosed in this specification will be described in detail with reference to the attached drawings. Identical or similar components regardless of drawing symbols are assigned the same reference number, and redundant descriptions thereof will be omitted. The suffixes "module" and "part" used for components in the following description are assigned or