KR-20260064759-A - Composition for Skin whitening, Skin Moisturizing, Antioxidant, Skin Soothing and Pore Tightening Activity Comprising Fermented Extract of Centella asiatica and Saururus chinensis as Active Ingredient

Abstract

The present invention relates to a composition for improving skin condition comprising a complex fermented extract of Centella asiatica and Trianthema portulacastrum as an active ingredient. The composition of the present invention is non-cytotoxic, effectively inhibits melanin production in skin cells to exhibit excellent skin whitening activity, has an excellent pore-tightening effect that promotes pore contraction in a concentration-dependent manner, inhibits the production of nitric oxide (NO), an inflammatory mediator to exhibit excellent synergistic effects for anti-inflammation and skin soothing, inhibits the production of reactive oxygen species (ROS) to exhibit excellent antioxidant activity, and increases the production of hyaluronic acid to exhibit excellent skin moisturizing activity, so it can be usefully utilized in cosmetics, food, and quasi-drugs for improving skin condition. Furthermore, the skin condition improvement composition of the present invention is not only very safe for the human body, but also has excellent stability.

Inventors

• 양지혜
• 이상규
• 이다진
• 김태현
• 배은설

Assignees

• 주식회사 피에프네이처

Dates

Publication Date

20260508

Application Date

20241028

Claims (10)

1. A cosmetic composition for improving skin condition comprising a complex fermented extract of Centella asiatica and Trianthema portulacastrum as an active ingredient.
2. In paragraph 1, The above Centella asiatica and Triosteum sinense are characterized by being blended in a weight ratio of 1:0.8 to 1.2 based on the raw materials. Cosmetic composition for improving skin condition.
3. In paragraph 1, The above-mentioned complex fermented extract is characterized as a complex fermented extract obtained by fermenting a complex extract of Centella asiatica and Trianthema portulacastrum with the Saccharomyces cerevisiae pfbio101 strain (accession number KCTC 14129BP) and the Lactobacillus pentosus pfbio035 strain (accession number KCTC 14684BP). Cosmetic composition for improving skin condition.
4. In paragraph 1, The above-mentioned complex fermented extract is characterized by inhibiting melanin production and exhibiting skin whitening activity. Cosmetic composition for improving skin condition.
5. In paragraph 1, The above-mentioned complex fermented extract is characterized by exhibiting skin pore-tightening activity. Cosmetic composition for improving skin condition.
6. In paragraph 1, The above-mentioned complex fermented extract is characterized by exhibiting anti-inflammatory activity by inhibiting the production of nitric oxide (NO), an inflammatory mediator. Cosmetic composition for improving skin condition.
7. In paragraph 1, The above complex fermented extract is characterized by exhibiting antioxidant activity by inhibiting the generation of reactive oxygen species (ROS). Cosmetic composition for improving skin condition.
8. In paragraph 1, The above-mentioned complex fermented extract is characterized by increasing the production of hyaluronic acid to exhibit skin moisturizing activity. Cosmetic composition for improving skin condition.
9. A food composition for improving skin condition comprising a complex fermented extract of Centella asiatica and Trianthema portulacastrum as an active ingredient.
10. A quasi-drug composition for improving skin condition comprising a complex fermented extract of Centella asiatica and Trianthema portulacastrum as an active ingredient.

Description

Composition for Skin whitening, Skin Moisturizing, Antioxidant, Skin Soothing and Pore Tightening Activity Comprising Fermented Extract of Centella asiatica and Saururus chinensis as Active Ingredient The present invention relates to a composition for skin whitening, moisturizing, antioxidant, soothing, and pore improvement comprising a complex fermented extract of Centella asiatica and Trianthema portulacastrum as an active ingredient. Some of the substances that play a crucial role in maintaining homeostasis in living organisms are physiologically active substances derived from various organisms. Extensive research has been conducted on numerous physiologically active substances to date, and among them, the study of physiologically active substances isolated from microorganisms, plants, or animals is a very important area in the fields of life science and medicine. There are substances known to be effective for improving skin elasticity, whitening, and antioxidant properties, such as Vitamin C, retinoic acid, and transforming growth factor (TGF), which have been developed in the past. However, materials such as Vitamin C, retinoic acid, transforming growth factor (TGF), animal placenta-derived protein (JP 1996-231370A), betulinic acid (JP 1996-208424A), and Chlorella extract (JP 2001-072567A) have had problems such as limited usage amounts due to safety issues like irritation and redness when applied to the skin, or their effects are so minimal that they cannot be expected to have a substantial effect on skin improvement. Furthermore, there is a recent trend of active development in cosmetics that enhance functionality by introducing physiologically active substances derived from natural sources to further strengthen the skin's own inherent defense mechanisms. Consequently, there is an urgent need for the development of natural materials that are safe for the body, have stable active ingredients, and, above all, are more effective than existing substances for skin whitening, pore improvement, anti-inflammatory, and antioxidant purposes. Meanwhile, cosmetic ingredients must strike a balance between safety, efficacy, and physical properties. Furthermore, as economic feasibility is a crucial factor, cosmetic materials are developed using various methods, such as natural extraction and fermentation by microorganisms, to optimize skin penetration, anti-aging properties, physiological activity, safety, and physical characteristics. Moreover, as the boundaries between cosmetics, food, and pharmaceuticals blur, a diverse range of cosmeceutical products continues to experience high growth through complex functional ingredients and biomaterials that combine the safety of cosmetics with the efficacy of pharmaceuticals and health functional foods. Against this background, the inventors conducted research on combinations of materials that exhibit excellent effects in improving skin condition, such as skin whitening, skin pore improvement, anti-inflammatory, antioxidant, and skin moisturization. As a result of diligent research efforts to find combinations of natural materials that exhibit various skin condition improvement effects, they confirmed that a complex fermented extract produced by combining Centella asiatica and Trianthema portulacastrum and fermenting it with two strains of Saccharomyces cerevisiae and Lactobacillus pentosus exhibits excellent activity in skin whitening, skin pore improvement, anti-inflammatory, antioxidant, and skin moisturization, and can be usefully utilized for the purpose of improving skin condition, thereby completing the present invention. Figure 1 is a graph showing the survival rate of Melan-A cells after treatment with Centella asiatica extract, Triosteum sinense extract, a complex extract of Centella asiatica and Triosteum sinense, and a complex fermented extract of Centella asiatica and Triosteum sinense. Figure 2 is a graph showing the change in melanin production according to treatment with Centella asiatica extract, Triosteum sinense extract, a complex extract of Centella asiatica and Triosteum sinense, and a complex fermented extract of Centella asiatica and Triosteum sinense. Figure 3 is a graph showing the change in the precipitation rate (%) of hemoglobin according to treatment with a complex fermented extract of Centella asiatica and Trianthema portulacastrum. Figure 4 is a graph showing the change in nitric oxide (NO) production according to treatment with Centella asiatica extract, Triosteum sinense extract, a complex extract of Centella asiatica and Triosteum sinense, and a complex fermented extract of Centella asiatica and Triosteum sinense. Figure 5 is a graph showing the change in the amount of reactive oxygen species (ROS) produced according to treatment with Centella asiatica extract, Triosteum sinense extract, a complex extract of Centella asiatica and Triosteum sinense, and a complex fermented extract of Centella asiatica and Triosteum sinense. Figure 6 is a gr