KR-20260064996-A - Compositioj for antiobesity comprising feremted extract of Moringa

Abstract

The present invention relates to an anti-obesity composition comprising a fermented Moringa extract, and more specifically, to an anti-obesity composition comprising, as an active ingredient, a fermented Moringa extract obtained by mixing Moringa leaves with yeast and Makgeolli and fermenting them. The fermented Moringa extract according to the present invention has no cytotoxicity and has effects such as inhibiting the differentiation of adipocytes and reducing the expression of major differentiation regulators of adipocytes, such as C/EBPα and PPARγ; therefore, it can be usefully utilized as a pharmaceutical composition or food composition for the prevention, improvement, or treatment of obesity.

Inventors

• 신춘호
• 백승한
• 박대훈
• 이순영

Assignees

• 순천만모링가협동조합

Dates

Publication Date

20260508

Application Date

20241030

Claims (6)

1. (S10) a step of drying and pulverizing moringa leaves; (S20) a step of mixing yeast and raw makgeolli with the moringa leaves from step (S10) and fermenting them; (S30) a step of extracting the fermented product from step (S20) with hot water; a method for preparing a fermented extract of moringa leaves.
2. A method for preparing a fermented extract of Moringa leaves according to claim 1, wherein the mixture in step (S10) comprises 100 parts by weight of Moringa leaves, 30 to 40 parts by weight of yeast, and 400 to 600 parts by weight of Makgeolli.
3. A method for preparing a fermented extract of Moringa leaves according to claim 1, characterized in that the extraction in step (S30) is performed in hot water at 70 to 90°C for 8 to 20 minutes.
4. A method for preparing a fermented extract of Moringa leaves according to claim 1, characterized in that the fermented extract of Moringa leaves inhibits the differentiation of adipocytes and reduces the expression of C/EBPα and PPARγ, which are adipocyte differentiation regulatory factors.
5. A pharmaceutical composition for the prevention or treatment of obesity comprising, as an active ingredient, a fermented extract of Moringa leaves according to any one of claims 1 to 4.
6. A food composition for the prevention or improvement of obesity comprising a fermented extract of Moringa leaves according to any one of claims 1 to 4 as an active ingredient.

Description

Composition for antiobesity comprising fermented extract of Moringa The present invention relates to an anti-obesity composition comprising a fermented Moringa extract, and more specifically, to an anti-obesity composition comprising a fermented Moringa extract as an active ingredient that is non-cytotoxic and has excellent efficacy in the differentiation and proliferation of adipocytes. Obesity refers to a condition in which adipose tissue is abnormally increased due to the excessive accumulation of energy in the body caused by an imbalance between energy intake and expenditure. The World Health Organization (WHO) defines a Body Mass Index (BMI) of 23–25 as overweight, 25–30 as obese, and 30 or higher as severely obese based on Asian standards. The causes of obesity include environmental factors such as a high-fat, high-calorie diet, lack of exercise due to a busy social environment, and endocrine disorders, as well as genetic factors. Among these, it is known that about 50 to 70% of obesity is caused by environmental factors, and the remainder is caused by genetic factors. However, most experts view obesity not as a disease caused by a single factor, but as the result of the complex interplay of various genetic, environmental, social, and psychological factors; therefore, there is a view that it is difficult to treat obesity using any single method. Currently, methods for treating obesity can be divided into lifestyle modification techniques, such as dietary therapy, exercise therapy, and behavioral therapy, as well as drug therapy or surgical treatment. While active efforts to correct lifestyle habits must precede drug or surgical treatment, lifestyle modification is not only difficult but also has limitations in terms of weight reduction. Therefore, in many cases, drug treatment is necessary alongside lifestyle modifications. Although many anti-obesity agents are developed annually for the pharmacological treatment of obesity, there are currently few available drugs, and most are limited to agents that suppress digestion or appetite. Agents that regulate digestion or appetite are classified as psychotropic drugs due to their addictive nature, and digestive inhibitors cause side effects such as diarrhea and constipation. Meanwhile, Moringa is a plant that grows naturally mainly in India, Africa, South America, and Southeast Asia. There are 13 species of Moringa trees belonging to the Moringaceae family, with Moringa oleifera being the most widely known. Moringa possesses strong vitality and is also called the "miracle tree." The world is paying attention to it as a next-generation superfood because it contains over 90 types of abundant nutrients, including protein, fiber, potassium, and calcium. It also contains high concentrations of various nutrients, such as three times the iron found in spinach, ten times the vitamin C found in oranges, and eight times the polyphenols found in red wine. Various technologies aimed at utilizing these active ingredients of Moringa have been disclosed. For example, Korean Patent Publication No. 10-2015-0144963 discloses a composition for obtaining enhanced cancer treatment or prevention effects while minimizing radiation side effects through the combined treatment of Moringa leaf extract and a small amount of radiation. Korean Published Patent No. 10-2020-0009510 discloses a composition for adsorbing or removing fine dust containing Moringa extract. Korean Published Patent No. 10-2022-0142700 discloses an anti-inflammatory composition containing a fermented Moringa oleifera product, obtained by fermenting Moringa oleifera with Bifidobacterium animalis subsp. Lactis , as an active ingredient. Korean Published Patent No. 10-2013-0088224 discloses a skin whitening composition containing an extract prepared by subcritical extraction of germinated Moringa seeds as an active ingredient. Accordingly, the inventors focused on the anti-obesity use of Moringa and confirmed that Moringa leaf extract is very useful for improving obesity. Subsequently, through continued research, they discovered that the fermented Moringa extract exhibits superior effects in inhibiting the differentiation of adipocytes and reducing the expression of key differentiation regulators without cytotoxicity compared to the unfermented extract, thereby completing the present invention. Figure 1 is a figure showing the results of cytotoxicity when the hot water extract of the Moringa Makgeolli fermented product of Preparation Example 1 according to one embodiment of the present invention (Moringa fermentation + Makgeolli hot water extract) was treated to 3T3-L1 preadipocytes at different concentrations. Figure 2 is a figure showing the results of cytotoxicity when the hot water extract of the fermented Moringa product of Preparation Example 2 according to one embodiment of the present invention (fermented Moringa hot water extract) was treated to 3T3-L1 preadipocytes at different concentrations. Figure 3 is a