KR-20260065075-A - A bactericidal composition containing thymol and carvacrol as active ingredients

Abstract

The present invention relates to a disinfectant composition containing carvacrol and thymol as active ingredients, and specifically, to a disinfectant composition containing carvacrol and thymol as active ingredients in which the bactericidal effect against strains such as Aspergillus niger (NBRC 6341), Aspergillus brasiliensis (ATCC 9642), Penicillium pinophilum (ATCC 11797), Chaetomium globosum (ATCC 6205), Trichoderma virens (ATCC 9645), and Aureobasidium pullulans (ATCC 15233) is enhanced by mixing carvacrol and thymol in a specific ratio.

Inventors

• 이일영
• 조연재
• 최영신
• 이민수
• 최유나

Assignees

• 한국화학연구원
• 주식회사 바이오미스트테크놀로지

Dates

Publication Date

20260508

Application Date

20241031

Claims (6)

1. A disinfectant composition characterized by containing carvacrol and thymol as active ingredients
2. In paragraph 1, A disinfectant composition characterized by being mixed with carvacrol and thymol in a ratio of 3:7 to 5:5 (volume%).
3. In paragraph 2, A disinfectant composition characterized by being mixed in a ratio (volume%) of 3.5:6.5 to 5:5.
4. In paragraph 3, A disinfectant composition characterized by being mixed in a ratio (volume%) of 4:6 to 5:5.
5. In paragraph 1, A disinfectant composition characterized by further including solvent and fragrance components depending on the use of the disinfectant composition.
6. In paragraph 5, A disinfectant composition characterized by being used as a fragrance, a general disinfectant, or applied to a mass disinfection system.

Description

A bactericidal composition containing carvacrol and thymol as active ingredients The present invention relates to a disinfectant composition containing carvacrol and thymol as active ingredients, and specifically, to a disinfectant composition containing carvacrol and thymol as active ingredients in which the bactericidal effect against strains such as Aspergillus niger (NBRC 6341), Aspergillus brasiliensis (ATCC 9642), Penicillium pinophilum (ATCC 11797), Chaetomium globosum (ATCC 6205), Trichoderma virens (ATCC 9645), and Aureobasidium pullulans (ATCC 15233) is enhanced by mixing carvacrol and thymol in a specific ratio. Disinfectants are substances that prevent the growth or inhibit the reproduction of microorganisms. Currently, there are about 130 types of industrial antimicrobial agents developed, but considering human safety and environmental aspects, it is desirable to use natural antimicrobial agents extracted from natural organisms. Natural antimicrobial agents are substances that inhibit microbial contamination and growth, and are widely used in various fields as food additives, pharmaceuticals, and industrial materials. In particular, as records and cultural heritage have been exposed to various contaminated environments or incorrect temperatures and humidity over long periods, they have become contaminated and damaged by numerous molds, pests, pathogenic microorganisms, and insects; therefore, the aforementioned natural antimicrobial agent can also be applied as a disinfectant for records and cultural heritage. Currently developed natural antimicrobial agents include Hinokitiol, an extract from Japanese cypress; Megnonol, an extract from magnolia; and DF-100, an extract from grapefruit seeds, but their usage is still only 17% of that of synthetic preservatives. As prior art regarding antimicrobial compositions containing essential oil components, Korean Published Patent No. 10-2005-71981, “Antimicrobial and antifungal composition containing plant essential oil,” relates to a composition in which the essential oil is selected from the group including thyme white, thyme red, cade, bay, oregano, clove bud, and clove leaf, but is a composition containing only a single essential oil as an active ingredient without a specific ratio, and Korean Published Patent No. 10-2000-72252, “Natural plant essential oil composition having household hygiene pest control effect and antimicrobial effect and preparation thereof,” relates to a composition including plant essential oils from mustard essential oil, lemon essential oil, ginger extract, and thyme extract. In addition, the “essential oil composition having antibacterial and antifungal activity” of Korean Registered Patent No. 10-285781 relates to an antibacterial composition comprising an essential oil selected from i) oregano, ii) dill, lavender, lemon balm, rosemary, mint, savory, sage, scented geranium, self-heal, sweet basil, chervil, thyme, tansy, cinnamon, clove, eucalyptus, lemon, peppermint, and pittree, which are plant essential oil components. Meanwhile, thymol is a natural substance found mainly in thyme oil that has a strong scent and has the chemical name [2-isopropyl-5-methylphenol]. Thymol is reported to have excellent antibacterial, antioxidant, anti-inflammatory, and scar-removing effects. Recently, its use as a natural pesticide and preservative to protect food from pathogenic microorganisms during sowing and storage has been reported, and research results on its activity as an insecticide, aphid control agent, and anthelmintic have also been reported. In addition, Carvacrol, which has the chemical name [2-methyl-5-(1-methylethyl)phenol], is known to be an isomer of Thymol. Like Thymol, it is known to be effective against antibacterial, antioxidant, and anticancer agents. In particular, it is known to be effective against foodborne pathogens, including E. coli, Salmonella, and Bacillus cereus. Furthermore, Carvacrol possesses high antioxidant activity and is utilized as a dietary plant additive along with Thymol. Despite these research results, natural substances containing the aforementioned thymol and carvacrol have the disadvantage of being difficult to formulate because the content of the components varies depending on the extraction site, time, and method; furthermore, technological development regarding compositions with enhanced antibacterial effects is insufficient. Accordingly, the inventors of the present invention completed the invention by developing a disinfectant composition exhibiting an enhanced bactericidal effect by combining thymol and carvacrol as pure compounds in a specific ratio. The present invention will be described in more detail below. Unless otherwise defined, technical and scientific terms used herein shall have the meanings commonly understood by those skilled in the art to which this invention pertains; furthermore, descriptions of known functions and configurations that could unnecessarily obscure the essen