KR-20260065109-A - Composition for antioxidant or anti-inflammatory comprising Taxus cuspidata fruit extracts

Abstract

The present invention relates to an antioxidant and anti-inflammatory composition comprising yew tree extract, Japanese barberry extract, sea buckthorn extract, blueberry extract, and French maritime pine extract. According to one aspect, the composition activates SOD, scavenges DPPH free radicals, and inhibits the production of nitric oxide (NO), thereby having antioxidant and anti-inflammatory effects.

Inventors

• 김영철
• 정경진
• 유성민
• 신유경
• 안혜신
• 나창선

Assignees

• (주)교원헬스케어

Dates

Publication Date

20260508

Application Date

20241031

Claims (13)

1. A health functional food composition for antioxidant or anti-inflammatory purposes comprising extracts of Taxus cuspidata , Berberis darwinii , Hippophae rhamnoides , Vaccinium spp., and Pinus pinaster .
2. A health functional food composition according to claim 1, wherein the composition activates superoxide dismutase, exhibits DPPH free radical scavenging ability, or inhibits the production of nitric oxide (NO).
3. A health functional food composition according to claim 1, wherein the yew tree ( Taxus cuspidata ) extract is included in an amount of 1 to 15 weight% based on the total weight of the composition.
4. A health functional food composition according to claim 1, wherein the Berberis darwinii extract is included in an amount of 30 to 50 weight% based on the total weight of the composition.
5. A health functional food composition according to claim 1, wherein the extract of * Hippophae rhamnoides * is included in an amount of 10 to 30 weight% based on the total weight of the composition.
6. A health functional food composition according to claim 1, wherein the blueberry ( Vaccinium spp.) extract is included in an amount of 10 to 30 weight% based on the total weight of the composition.
7. A health functional food composition according to claim 1, wherein the French maritime pine ( Pinus pinaster ) extract is included in an amount of 1 to 20 weight% based on the total weight of the composition.
8. A health functional food composition according to claim 1, wherein the yew ( Taxus cuspidata ) extract, multi-barberry ( Berberis darwinii ) extract, sea buckthorn ( Hippophae rhamnoides ) extract, blueberry ( Vaccinium spp.) extract and French maritime pine ( Pinus pinaster ) extract are mixed in a weight ratio of 1:5:2:2:1 to 1:8:5:5:2.
9. A health functional food composition according to claim 1, wherein the health functional food has a formulation selected from the group consisting of powders, granules, tablets, capsules, pills, gels, jellies, suspensions, emulsions, syrups, tea bags, infused teas, gum, candies, and health drinks.
10. A cosmetic composition for antioxidant or anti-inflammatory purposes comprising yew tree extract, barberry extract, sea buckthorn extract, blueberry extract, and French maritime pine extract.
11. An anti-inflammatory topical skin composition comprising yew tree extract, barberry extract, sea buckthorn extract, blueberry extract, and French maritime pine extract.
12. A pharmaceutical composition for the prevention or treatment of skin inflammatory diseases comprising yew tree extract, barberry extract, sea buckthorn extract, blueberry extract, and French maritime pine extract.
13. A pharmaceutical composition according to claim 10, wherein the skin inflammatory disease is any one selected from the group consisting of skin wound, dermatitis, atopic dermatitis, pruritus, eczematous skin disease, dry eczema, erythema, urticaria, psoriasis, drug rash, and acne.

Description

Composition for antioxidant or anti-inflammatory comprising Taxus cuspidata fruit extracts The present invention relates to an antioxidant or anti-inflammatory composition comprising yew fruit extract. Oxidative reactions occurring within the body can accelerate aging and cell mutations, potentially contributing to the formation of cancer cells. Antioxidant functions play a role in preventing these negative changes by inhibiting or slowing down these oxidative reactions. Therefore, antioxidant functions are receiving attention as an important method for maintaining health and preventing disease. Meanwhile, mitochondria play a central role in cellular respiration and energy production (ATP production) within the body, generating free radicals in the process. Free radicals are unstable and react rapidly with lipids, nucleic acids, and proteins, causing damage. Inhibiting the generation of these free radicals can prevent oxidation processes within the body, which can contribute to the prevention of aging and cancer. Accordingly, the development of functional materials with anti-inflammatory effects is receiving significant attention. Furthermore, the inflammatory response is a physiological reaction designed to protect the body from harmful environmental factors, such as the invasion of foreign substances like bacteria or physicochemical damage. During this process, immune cells recognize foreign substances and become activated, secreting various factors that mediate inflammation. NO, a representative inflammatory mediator, sees a rapid increase in production when iNOS becomes excessively activated. NO interacts with the COX-2 pathway to promote the production of inflammatory mediators like PGE2 (prostaglandin E2), and also activates inflammatory pathways such as NF-κB, thereby intensifying the inflammatory response by causing the expression of various inflammation-related genes. Excessive inflammatory responses can act in conjunction with reactive oxygen species (ROS) and become a cause of chronic inflammatory diseases. Therefore, the development of functional materials with anti-inflammatory effects, such as inhibiting the production of NO, is considered important for the prevention and treatment of various chronic inflammatory diseases. Plant-derived materials have long been used due to their superior safety, and in Korea, in particular, the development of functional materials primarily based on plants and medicinal ingredients used in the private sector or traditional Korean medicine is actively underway. Accordingly, the inventors of the present invention, having endeavored to develop an antioxidant and anti-inflammatory composition using plant-derived materials, confirmed that a complex extract of yew, barberry, sea buckthorn, blueberry, and French maritime pine exhibits superior antioxidant and anti-inflammatory effects compared to a single extract, thereby completing the present invention. Figure 1 is a graph showing the amount of NO produced from LPS according to treatment with each yew fruit extract, multi-barberry fruit extract, sea buckthorn fruit extract, blueberry extract, French maritime pine bark extract, and a complex (KW05) containing all of the extracts. Figure 2 is a graph showing the amount of NO produced by UV-B when dermal cells (Hs68 fibroblasts) are treated with each of the following: yew fruit extract, barberry fruit extract, sea buckthorn fruit extract, blueberry extract, French maritime pine bark extract, and a complex (KW05) containing all of the above extracts. Figure 3 is a graph showing the amount of NO produced by UV-B when epidermal cells (Hacat) are treated with each of the following: yew fruit extract, barberry fruit extract, sea buckthorn fruit extract, blueberry extract, French maritime pine bark extract, and a complex (KW05) containing all of the above extracts. The following examples will be explained in more detail. However, these examples are for illustrative purposes only and the scope of the present invention is not limited to these examples. Example 1. Preparation of a complex (KW05) containing yew tree extract, etc. A complex (KW05) containing yew tree extract, etc., was prepared by mixing individual extracts obtained from individual ground materials of yew tree fruit, barberry fruit, sea buckthorn fruit, blueberry, and French maritime pine bark, which were each washed, dried, and ground. The above-mentioned complex (KW05) containing yew tree extracts, etc. was prepared by mixing 6.25% by weight of yew tree fruit extract, 41.67% by weight of barberry fruit extract, 20.83% by weight of sea buckthorn fruit extract, 20.83% by weight of blueberry extract, and 10.42% by weight of French maritime pine bark extract based on total weight. Specifically, yew fruit extract, barberry fruit extract, sea buckthorn fruit extract, blueberry extract and French maritime pine bark extract were mixed in a weight ratio of 1 : 6.67 : 3.33 : 3.33 : 1.67. Experimental Example 1. Confirmat