KR-20260065782-A - Composition for preventing or treating liver-related diseases comprising ginger juice as an active ingredient

Abstract

The objective of the present invention is to provide a composition for the prevention or treatment of liver-related diseases comprising ginger juice as an active ingredient. When ginger juice was administered in a CCl-induced acute liver injury in Wistar rats model, the rats' body weight, liver weight, and liver index were measured, and it was confirmed that the rats' body weight increased and their liver weight and liver index recovered. Furthermore, to measure the hepatoprotective effect of ginger juice, blood liver enzymes ALP, Gamma-GT, ALAT, ASAT, direct bilirubin, and total plasma bilirubin were measured, and all were found to decrease, confirming that it has a hepatoprotective effect. Additionally, histological confirmation of the hepatoprotective effect of ginger juice revealed significant recovery, which can be usefully applied in related businesses.

Inventors

• 김봉이
• 오사마 베코우치
• 소울리만 암라니
• 모하메드 달리

Assignees

• 경희대학교 산학협력단

Dates

Publication Date

20260511

Application Date

20260427

Claims (6)

1. A food composition for preventing or improving liver fibrosis comprising ginger ( Zingiber officinale ) juice as an active ingredient, The above ginger juice is extracted by crushing the root portion of ginger at 25℃, and The above composition is a food composition that reduces blood levels of gamma-GT (gamma-glutamyl transferase), direct bilirubin, and total plasma bilirubin.
2. In Article 1, A food composition comprising the ginger juice containing 4-gingerol, 6-gingediol, and 6-gingerol, wherein the 6-gingerol is contained in a ratio of 70 to 90 parts by weight relative to 1 part by weight of 6-gingediol.
3. In Article 1, The above composition is a food composition characterized by regenerating the plasma membrane of liver cells damaged by carbon tetrachloride ( CCl4 ) and repairing liver tissue.
4. A step of crushing the root portion of ginger ( Zingiber officinale ) at 25℃ and extracting juice; A step of filtering the extracted ginger juice; and A food composition for preventing or improving liver fibrosis comprising ginger juice as an active ingredient, prepared by a method including the step of drying the filtered ginger juice above; The above composition is a food composition that reduces blood levels of gamma-GT (gamma-glutamyl transferase), direct bilirubin, and total plasma bilirubin.
5. A liver-protective feed composition comprising ginger ( Zingiber officinale ) juice as an active ingredient, The above ginger juice is obtained by crushing the root portion of ginger at 25°C and extracting the juice, and contains 4-gingerol, 6-gingediol, and 6-gingerol. The above composition is a feed composition that reduces blood levels of gamma-GT (gamma-glutamyl transferase), direct bilirubin, and total plasma bilirubin.
6. A pharmaceutical composition for the prevention or treatment of liver fibrosis comprising ginger ( Zingiber officinale ) juice as an active ingredient, The above ginger juice is obtained by crushing the root portion of ginger at 25°C and extracting the juice, and contains 4-gingerol, 6-gingediol, and 6-gingerol. The above composition is a pharmaceutical composition that reduces blood levels of gamma-GT (gamma-glutamyl transferase), direct bilirubin, and total plasma bilirubin.

Description

Composition for preventing or treating liver-related diseases comprising ginger juice as an active ingredient The objective of the present invention is to provide a composition for the prevention or treatment of liver-related diseases comprising ginger juice as an active ingredient. Ginger is also known as Saeang or Saeyang. It is native to Southeast Asia and is cultivated as a vegetable. The rhizome grows horizontally, is fleshy, lumpy, and yellow, with a spicy taste and a fragrant smell. At each node of the rhizome, false stems formed from leaf sheaths stand upright, reaching a height of 30 to 50 cm, with leaves arranged in two rows at the top. The leaves are alternate and linear-lanceolate, forming leaf sheaths that are narrow at both ends and long at the base. In traditional Korean medicine, the dried rhizome of ginger is used as a medicinal herb. Ginger is used to treat chills, fever, headache, vomiting, cough, and phlegm caused by the common cold. It is also effective for abdominal pain, diarrhea, and bloating caused by food poisoning, so it is often brewed in boiling water and consumed as a tea. Pharmacological effects reported include promoting gastric juice secretion, enhancing digestion, stimulating the heart, promoting blood circulation, and antibacterial action. In Chinese characters, it is also known as Ganggeun (姜根), Mogang (母薑), Baeklalyun (百辣蕓), Yeomnyangsoja (炎凉小子), Injicho (因地草), Jagang (子薑), Jagang (紫薑), and Geongang (乾薑). In addition, the rhizomes are dried and ground to be used as a spice in bread, pastries, curry, sauces, and pickles; they are also peeled, boiled, and preserved in syrup to make ginger tea and ginger wine. Liver disease is generally a progression that develops from hepatitis to liver fibrosis, cirrhosis, and liver cancer. Factors triggering hepatitis in the early stages include hepatotoxic substances, hepatitis viruses, drugs, alcohol, and autoimmune reactions, and repeated inflammatory responses caused by these factors induce progression to the next stage. Acute alcohol consumption is known to cause direct or indirect toxic effects in humans, and byproducts such as acetaldehyde and acetate cause damage to liver cells. More than 80–90% of ingested ethanol is metabolized in the liver, where it is oxidized to acetaldehyde. Many of the toxic effects of ethanol on the liver are explained by oxidative stress caused by ethanol metabolism. Ethanol or its metabolites cause auto-oxidation in hepatocytes and lead to hepatitis by acting as pro-oxidative factors or by reducing antioxidant levels. The association between lipid oxidation and membrane damage is a key characteristic of ethanol-induced liver injury. Excessive alcohol consumption and drug-induced liver injury cause liver fibrosis, serving as the first link in the chain leading from liver cirrhosis to liver cancer. However, modern individuals consistently consume alcohol for stress, social life, and pleasure, and take medications that induce liver damage due to various diseases. Consequently, there is an urgent need to develop materials capable of protecting the liver. While various hangover remedies are available on the market, very few materials have been developed into pharmaceuticals with recognized significant efficacy. Therefore, developing new liver-protective materials into food or pharmaceutical products would benefit public health and lead to industrial success. Accordingly, while researching ginger, the inventors confirmed the liver cell protection and liver-related disease treatment of ginger, and thus completed the present invention. Figure 1 is the result of analyzing the active ingredients of the ginger juice of the present invention by HPLC-MS. Figure 2 is a figure confirming the structure of three types of phenolic compounds contained in the ginger juice of the present invention. Figure 3 shows the recovery of body weight, liver weight, and liver index when ginger juice was administered to a mouse model of liver damage (liver fibrosis). Figure 4 shows the liver enzyme levels when ginger juice is administered to a mouse model of liver damage (liver fibrosis). Figure 5 shows the liver histopathological changes when ginger juice is administered to a liver injury mouse model (liver fibrosis). Hereinafter, the present invention will be described in detail with reference to the attached drawings and embodiments thereof. However, the following embodiments are presented as examples of the present invention, and if it is determined that a detailed description of a technology or configuration well known to those skilled in the art may unnecessarily obscure the essence of the present invention, such detailed description may be omitted, and the present invention is not limited by this. The present invention is capable of various modifications and applications within the scope of the claims set forth below and the equivalent scope interpreted therefrom. Furthermore, the terminology used in this specification is used t