KR-20260065880-A - Suppression of sacrificial metal-based radiodecomposition during the chromatographic separation process of radioisotopes

Abstract

The present specification provides a method for purifying a chemical element (e.g., a radioactive isotope) using a sacrificial metal dopant and/or a radical scavenger during a chromatographic separation process of a desired element, thereby suppressing undesirable radiodegradation.

Inventors

• 모멘, 압둘

Assignees

• 샤인 테크놀로지스 엘엘씨

Dates

Publication Date

20260511

Application Date

20240913

Priority Date

20230915

Claims (20)

1. As a method for purifying chemical elements, the above method is, a) a step of obtaining a semi-purified sample by applying a composition containing a chemical element and one or more impurities to sublimation, distillation, or chromatography to remove at least a portion of one or more impurities from the composition; b) a step of adding a metal dopant to the semi-purified sample; and c) a step of applying the semi-purified sample containing the metal dopant to chromatographic separation to remove the metal dopant and other impurities, thereby obtaining a sample fraction concentrated with chemical elements; comprising a method.
2. In paragraph 1, A method wherein the metal dopant comprises lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, or salts thereof.
3. In paragraph 2, A method in which the above metal dopant is chelated.
4. In paragraph 1, A method in which the amount of metal dopant added to the above-mentioned semi-purified sample exceeds the amount of chemical element in the sample.
5. In paragraph 1, A method further comprising the step of chelating a semi-purified sample containing a metal dopant before the chromatographic separation and the step of dechelating a sample fraction concentrated with chemical elements after the chromatographic separation.
6. In paragraph 1, A method comprising a step of further concentrating chemical elements by applying a sample fraction concentrated with chemical elements to an additional chromatographic separation step.
7. In paragraph 6, A method comprising adding a radical scavenger to a sample fraction concentrated with chemical elements prior to the additional chromatographic separation step.
8. In paragraph 6, A method in which a sample fraction concentrated with chemical elements is not chelated during an additional chromatographic separation step.
9. In paragraph 8, A method in which the above chemical element is lutetium.
10. In paragraph 1, A method in which the above chemical element is a radioactive isotope.
11. In any one of paragraphs 1 through 10, A method in which one or more of the above impurities include ytterbium.
12. As a method for purifying chemical elements, the above method is, a) a step of obtaining a semi-purified sample by applying a composition containing a chemical element and one or more impurities to sublimation, distillation, or chromatography to remove at least a portion of one or more impurities from the composition; b) a step of applying the semi-purified sample to chromatographic separation to obtain a sample fraction in which the chemical element is concentrated; and c) a step of contacting a sample fraction concentrated with the chemical element with a radical scavenger, and applying the sample fraction and the radical scavenger to additional chromatographic separation to remove the radical scavenger and other impurities; comprising a method.
13. In Paragraph 12, A method further comprising the step of chelating a semi-purified sample before the chromatographic separation and the step of dechelating a sample fraction concentrated with chemical elements after the chromatographic separation.
14. In Paragraph 12, A method in which a sample fraction containing a radical scavenger is not chelated during additional chromatographic separation.
15. In Paragraph 12, A method in which the above chemical element is lutetium.
16. In Paragraph 12, A method in which the above chemical element is a radioactive isotope.
17. In any one of paragraphs 12 through 16, A method in which one or more of the above impurities include ytterbium.
18. As a system, the above system is, a) A composition comprising lutetium and one or more impurities; b) one or more chromatographic resins; and c) a system comprising a radical scavenger and/or a metal dopant.
19. In Paragraph 18, A system in which the metal dopant comprises lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, or salts thereof.
20. In paragraph 18 or 19, The above system is a system contained within a hot cell.

Description

Suppression of sacrificial metal-based radiodecomposition during the chromatographic separation of radioisotopes Suppression of radiodecomposition Claim of priority This application claims priority to U.S. Provisional Patent Application No. 63/538,706 filed on September 15, 2023, the entire contents of said Provisional Patent Application incorporated herein by reference for all purposes. field The present specification provides a method for purifying a chemical element that minimizes the radiodegradation of a desired element during the purification process. In particular, the present specification provides a method for purifying a chemical element using a sacrificial metal dopant and/or a radical scavenger during the chromatographic separation process of a desired element, thereby suppressing undesirable radiodegradation. Radioisotopes such as lutetium-177 (Lu-177) are used in various diagnostic and therapeutic methods, including those for cancer. Current methods for separating radioisotopes suffer from the problem of radiodegradation occurring during the separation process. Therefore, there is a need for improved technology to purify radioisotopes like lutetium-177 while minimizing radiodegradation. According to a first aspect of the present invention, a method for purifying a chemical element comprises the steps of: obtaining a semi-purified sample by applying a composition containing a chemical element and one or more impurities to sublimation, distillation, or chromatography to remove at least a portion of one or more impurities from the composition; adding a metal dopant to the semi-purified sample; and obtaining a sample fraction concentrated with the chemical element by applying the semi-purified sample containing the metal dopant to chromatographic separation to remove the metal dopant and other impurities. The second aspect includes the method of the first aspect, and the metal dopant includes a lanthanide element. The third aspect comprises the method of the first aspect or the second aspect, wherein the metal dopant comprises lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, or salts thereof. The fourth aspect includes the method of any one of the previous aspects, and the metal dopant is chelated. The fifth aspect includes the method of any one of the previous aspects, wherein the amount of metal dopant added to the semi-purified sample exceeds the amount of chemical element in the sample. The sixth aspect comprises a method of any one of the preceding aspects, and further comprises the step of chelating a semi-purified sample containing a metal dopant before chromatographic separation and the step of dechelating a sample fraction concentrated with a chemical element after chromatographic separation. The seventh aspect includes any one of the previous aspects, wherein the chromatographic separation includes high performance liquid chromatography (HPLC). The eighth aspect comprises a method of any one of the preceding aspects, said method comprising a step of applying a sample fraction concentrated with chemical elements to an additional chromatographic separation step to further concentrate the chemical elements. The ninth aspect includes a method of any one of the previous aspects, and an additional chromatographic separation step includes HPLC. The tenth aspect comprises a method of any one of the preceding aspects, said method comprising the step of adding a radical scavenger to a sample fraction concentrated with chemical elements prior to or during an additional chromatographic separation step. The eleventh aspect comprises a method of any one of the previous aspects, wherein the radical scavenger is ascorbic acid or an inorganic salt thereof. The 12th aspect includes the method of any one of the previous aspects, wherein the radical scavenger is sodium ascorbate. The 13th aspect includes the method of any one of the previous aspects, wherein the sample fraction concentrated with chemical elements is not chelated during an additional chromatographic separation step. The 14th aspect includes the method of any one of the previous aspects, and the chemical element is a radioactive isotope. The 15th aspect includes the method of any one of the previous aspects, and the chemical element is lutetium. The 16th aspect includes the method of any one of the previous aspects, and the chemical element is lutetium-177. The 17th aspect comprises any one of the previous aspects, wherein one or more impurities include ytterbium. The 18th aspect comprises any one of the previous aspects and one or more impurities include ytterbium-176. The 19th aspect comprises a method of any one of the previous aspects, removing at least 50% of one or more impurities from the composition through sublimation, distillation, or chromatography. The 20th aspect includes a method of any one of the previous aspects, removing at leas