KR-20260065966-A - CURABLE POLYMERIC COMPOSITIONS

Abstract

Compounds and compositions useful for additive printing, particularly additive printing technology such as stereolithography (SLA), are provided, wherein a composition of one or more photocurable compounds, such as a compound having a plurality of ethylenically unsaturated groups and a compound having a plurality of thiol groups, is photopolymerized in the optional presence of two or more thermosetting compounds that are reactive to each other and thermally polymerized, to form a manufactured article in solid form.

Inventors

• 본 마이클 아론
• 사이니 프라브조트
• 스탠포드 매튜
• 부사리 하피즈
• 틴달 데브라

Assignees

• 폴리-메드, 인코포레이티드

Dates

Publication Date

20260511

Application Date

20201008

Priority Date

20191009

Claims (1)

1. A composition comprising: a first organic compound (polySH) having a plurality of thiol groups (SH), a second organic compound (polyEU) having a plurality of ethylenically unsaturated groups (EU), and a photoinitiator; and optionally a stabilizer.

Description

Curable Polymeric Compositions Cross-reference regarding related applications This application claims the benefit of 35 USC § 119(e) of U.S. Provisional Patent Application No. 62/913,063 filed on October 9, 2019, the entirety of which is incorporated herein by reference for all purposes. Technology field The present disclosure relates to the manufacture and use of curable compositions, such as photocurable and thermocurable compositions, for manufacturing bioabsorbable implants by an additive manufacturing process. Stereolithography (SLA) is a relatively well-developed additive printing technology for manufacturing three-dimensional (3-D) objects. In stereolithography methods, light, such as ultraviolet (UV) or visible light, is used to photopolymerize liquid materials into designed structures, such as three-dimensional articles, with high accuracy and precision. Continuous thin layers are photopolymerized by UV or visible light, for example, according to the guidance of a sliced computer-aided design (CAD) model. SLA uses a liquid photopolymerizable composition, which can typically be referred to as a resin or ink formulation. The macroscopic properties and degradation profiles of articles produced by SLA depend in part on the polymer chemistry and processing techniques. The present disclosure provides compounds and compositions useful for curing processes such as stereolithography (SLA) that have advantages over currently known compounds and compositions for this purpose. All topics discussed in the background section are not necessarily prior art; they are considered merely as a result of the discussion in the background section and should not be regarded as prior art. In this context, any awareness of problems in the prior art discussed in the background section or related to such topics should not be treated as prior art unless explicitly stated as such. Instead, any discussion of any topic in the background section should be treated as part of the inventor's approach to a particular problem and may also be original in itself. Briefly, in one embodiment, the present disclosure provides compounds and compositions useful for curing processes, such as photocuring processes or thermal curing processes used in conjunction with photocuring processes. Curing processes are useful for manufacturing articles such as medical devices and coatings. An exemplary curing process is stereolithography (SLA), which is an additive manufacturing process, in which a curable composition according to the present disclosure, containing one or more photoreactive compounds including, for example, a photoreactive macromer, is photopolymerized (photocured) during the process for forming a manufactured article. Another exemplary process is a coating process, in which the compounds and/or compositions of the present disclosure are placed on a surface by the coating process and then cured by exposure to heat (thermal curing) and/or exposure to chemical radiation (i.e., photopolymerization or photocuring) to provide a hard coating on the surface. These cured products, that is, products formed by curing a composition as disclosed herein, may be typically referred to herein as articles, coatings, films, materials, etc. Accordingly, it should be understood that when the present disclosure is illustrated by the manufacture of articles, coatings or other materials may likewise be manufactured. In one embodiment, articles, coatings, etc. are biodegradable. In one embodiment, the present disclosure provides biodegradable polymer materials formed by a curing process. The materials can be used to produce articles having a limited lifespan, so that, as a result, after a certain period, the article formed from the biodegradable material no longer exists. For example, the material may be a coating on a device, such as a medical device, and the coating degrades after a certain period. In another example, the material may be used to prepare a mesh for a medical device, for example, for tissue repair, so that over time, part or all of the article is no longer present and tissue repair is achieved. As another example, the medical device may be a tissue adhesive or sealant, and after the polymerizable composition of the present disclosure is applied to a tissue requiring an adhesive or sealant, the composition is exposed to chemical radiation sufficient to cause photopolymerization of the composition on the tissue. According to the present disclosure, in one embodiment, stereolithography may be used to produce such materials and articles, for example, using compounds and compositions as disclosed herein. The present disclosure addresses issues regarding thermosetting and photocuring materials, such as articles produced by SLA that come into contact with living organisms, and includes issues regarding the safety and efficacy of the produced articles, particularly their biocompatibility and cytotoxicity. In one embodiment, the present disclosure provide