KR-20260066012-A - ANIMAL-DERIVED AND PATIENT-SPECIFIC BONE CRAFT, MANUFACTURING METHOD OF THE SAME, AND TRANSFERING METHOD OF THE SAME

KR20260066012AKR 20260066012 AKR20260066012 AKR 20260066012AKR-20260066012-A

Abstract

The present invention relates to a bone graft material, and more specifically, by including a first layer having a shape corresponding to the surface of a bone defect and including at least one selected from the group consisting of cortical bone and cancellous bone, ease of use and implantation success rate can be improved.

Inventors

허중보

Assignees

(주)메드파크
부산대학교 산학협력단

Dates

Publication Date: 20260512
Application Date: 20260417

Claims (6)

As a patient-specific animal-derived bone graft material, it is an insert manufactured by cutting natural bone harvested from animals or the human body and coated with decellularized bone extracellular matrix (bdECM), and The above insert is, A first layer comprising cancellous bone having a shape corresponding to the surface of the bone defect; and A second layer covering at least a portion of the first layer and including cortical bone; comprising A patient-specific animal-derived bone graft material in which the cortical bone is included in a weight ratio of less than 0.2 relative to 1 weight part of the cancellous bone.
As a patient-specific animal-derived bone graft material, it is an insert manufactured by cutting natural bone harvested from animals or the human body and coated with decellularized bone extracellular matrix (bdECM), and The above insert is, A first layer comprising cancellous bone having a shape corresponding to the surface of the bone defect; and A second layer covering at least a portion of the first layer and including cortical bone; comprising A patient-specific animal-derived bone graft material in which the cortical bone is included in a weight ratio of 0.2 or more and less than 1 part per weight of the cancellous bone.
In Article 1 or Article 2, Patient-specific animal-derived bone graft material including additional guide holes for implant surgery.
As a method for manufacturing patient-specific animal-derived bone graft material, A step of generating three-dimensional shape image information of an insert to be inserted into a bone defect, including a shape corresponding to the surface of the bone defect; and The method includes the step of manufacturing the insert according to the above three-dimensional shape image information; and The step of manufacturing the above insert is, The method includes the step of cutting bone comprising at least one selected from the group consisting of cortical bone and cancellous bone, and The above insert is, A first layer comprising cancellous bone having a shape corresponding to the surface of the bone defect; and A second layer covering at least a portion of the first layer and including cortical bone; comprising The cortical bone is included in a weight ratio of less than 0.2 relative to 1 weight part of the cancellous bone, and The above insert is a method for manufacturing a patient-specific animal-derived bone graft material coated with decellularized bone extracellular matrix (bdECM).
As a method for manufacturing patient-specific animal-derived bone graft material, A step of generating three-dimensional shape image information of an insert to be inserted into a bone defect, including a shape corresponding to the surface of the bone defect; and The method includes the step of manufacturing the insert according to the above three-dimensional shape image information; and The step of manufacturing the above insert is, The method includes the step of cutting bone comprising at least one selected from the group consisting of cortical bone and cancellous bone, and The above insert is, A first layer comprising cancellous bone having a shape corresponding to the surface of the bone defect; and A second layer covering at least a portion of the first layer and including cortical bone; comprising The cortical bone is included in a weight ratio of 0.2 or more and less than 1.0 relative to 1 weight part of the cancellous bone, and The above insert is a method for manufacturing a patient-specific animal-derived bone graft material coated with decellularized bone extracellular matrix (bdECM).
In Article 4 or Article 5, A method for manufacturing a patient-specific animal-derived bone graft material, comprising the step of forming a guide hole for implant surgery in the above-mentioned insert.

Description

Patient-specific animal-derived bone graft material, method of manufacturing the same, and method of implanting the same The present invention relates to a patient-specific animal-derived bone graft material, a method for manufacturing the same, and a method for implanting the same. Various materials and methods can be used for the reconstruction of missing bone; for example, bone graft materials such as bone powder, bone chips, and bone blocks may be used, or methods such as autograft, allograft, and allograft may be used for the reconstruction of missing bone. Bone graft materials used for the reconstruction of bone defects can be used in orthopedics, neurosurgery, and dentistry; for example, they can be used in bone defects during disc surgery to induce bone regeneration, and can also be used in implant procedures and the restoration of oral and maxillofacial bone defects. Meanwhile, Korean Registered Patent No. 10-1345805 discloses technology regarding bone graft materials. However, when using bone graft materials in powder form for such grafting, there may be a lack of clinical reliability regarding the material, limitations of synthetic materials, difficulty in making small corrections during surgery, or difficulty in providing initial fixation during implant placement due to weak strength. Figure 1 shows the process of forming a surgical guide hole for a patient-specific animal-derived bone graft material according to the present invention. Figure 2 illustrates the process of forming an insert formed through three-dimensional shape image information of a bone defect according to the present invention. Figure 3 shows the manufacturing process of a patient-specific animal-derived bone graft material according to the present invention. Figure 4 is a photograph showing an SEM image observed by coating an insert with bdECM during the manufacturing process of a bone graft material according to the present invention. Figure 5 shows an example comparing the presence or absence of bone-forming protein added to the bone graft material during the manufacturing process of the bone graft material according to the present invention. Figure 6 shows the results of a compressive strength test according to the presence or absence of bdECM coating on the insert during the manufacturing process of the bone graft material according to the present invention. Figure 7 is a schematic diagram showing the implantation process of a patient-specific animal-derived bone graft material according to the present invention. Figure 8 shows the actual implantation process of a patient-specific animal-derived bone graft material according to the present invention. Embodiments of the present invention relate to a bone graft material that can improve ease of use and implantation success rate by including a first layer having a shape corresponding to the surface of a bone defect and at least one selected from the group consisting of cortical bone and cancellous bone. Embodiments of the present invention can have high cell affinity and appropriate porosity and high interfacial activity, can be processed accurately, can be reproducible and economical, and can be widely used clinically, can have an easy surgical method, short surgery and recovery times, and a low possibility of postoperative complications, can maximize bone synthesis, minimize mobility of the graft material, maximize bone formation, and can reconstruct bone with high biocompatibility and high strength. Specific embodiments of the present invention will be described below. However, these are merely examples and the present invention is not limited thereto. In describing the present invention, if it is determined that a detailed description of known technology related to the present invention may unnecessarily obscure the essence of the present invention, such detailed description will be omitted. Furthermore, the terms described below are defined considering their functions in the present invention, and these may vary depending on the intentions or conventions of the user or operator. Therefore, such definitions should be based on the content throughout this specification. The technical concept of the present invention is determined by the claims, and the following embodiments are merely a means to efficiently explain the technical concept of the present invention to those skilled in the art to which the present invention pertains. In this specification, the meanings of "first" and "second" are not to limit the number of objects modified by "first" and "second," but merely to distinguish between different objects modified. In the present invention, if there are isomers of a compound, the compound refers to a compound that includes the isomers. The bone graft material of the present invention comprises a first layer having a shape corresponding to the surface of a bone defect and at least one selected from the group consisting of cortical bone and cancellous bone. For example,