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KR-20260066171-A - COMPOSITIONS AND METHODS COMPRISING ENERGY ABSORBING MATERIALS FOR FOLLICULAR DELIVERY

KR20260066171AKR 20260066171 AKR20260066171 AKR 20260066171AKR-20260066171-A

Abstract

The present invention provides a composition comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and a method for delivering said particles through topical application. Such delivery is facilitated by mechanical stirring (e.g., massage), acoustic vibrations in the range of 10 Hz to 20 kHz, ultrasound, alternating suction and pressurization, and the application of a microjet.

Inventors

  • 파이탄카르, 딜립
  • 블롬그렌, 리차드 딘
  • 앤더슨, 리차드, 록스
  • 파리넬리, 윌리엄, 에이.
  • 도우카스, 아포스톨로스, 쥐.

Assignees

  • 더 제너럴 하스피탈 코포레이션

Dates

Publication Date
20260512
Application Date
20130314
Priority Date
20130307

Claims (13)

  1. A topical administration composition comprising a light-absorbing substance for treating or improving acne vulgaris, The above light-absorbing material comprises a plurality of light-absorbing micron particles present in an amount effective for inducing localized heating, dispersed in a carrier that is acceptable for pharmaceutical or cosmetic use, and The light-absorbing material comprises a silica core having a diameter of 150 nm and an optical density of 250 and a plasmonic gold shell, and has a peak absorption wavelength of 700 to 1,100 nm; The light-absorbing material is delivered via mechanical stirring, sonic vibration, ultrasound, alternating suction and pressurization, or a microjet to one or more selected from the group consisting of hair follicles, sebaceous glands, sebaceous ducts, and funnels; The light-absorbing material is exposed to energy activation of 40 to 50 J/ cm² ; The energy is light energy having a wavelength that is preferentially absorbed by a light-absorbing material, which emits heat, Local administration composition.
  2. A composition according to claim 1, wherein the skin is prepared by one or more selected from the group consisting of heat treatment, removal of follicular contents, and hair removal prior to the application step.
  3. A composition according to claim 1, wherein the skin is heat-treated at a temperature of 40°C to 44°C.
  4. A composition according to claim 1, wherein the light-absorbing material comprises a nanoplate, a solid nanoshell, a hollow nanoshell, a nanorod, a nanorice, a nanosphere, a nanofiber, a nanowire, a nanopyramid, a nanoprism, or a nanostar.
  5. A composition according to claim 1, wherein the light-absorbing material has a size of 0.01 micrometers to 1.0 micrometers.
  6. A composition according to claim 1, wherein the light-absorbing material is coated with PEG.
  7. A composition according to claim 1, wherein the light-absorbing material is transmitted through having a frequency of 20 kHz to 500 kHz.
  8. A composition according to claim 1, wherein the light-absorbing material is delivered through ultrasound-induced follicle-sized bubbles.
  9. A composition according to claim 1, wherein the light-absorbing material is delivered through the application of a plurality of light pulses.
  10. A composition comprising a light-absorbing material for removing body hair of a subject, The light-absorbing material comprises a silica core and a plasmonic gold shell dispersed in a carrier that is acceptable for pharmaceutical or cosmetic use, having a diameter of 150 nm and an optical density of 250, present in an amount effective for inducing localized heating; The light-absorbing material has a peak absorption wavelength of 700 to 1,100 nm; The light-absorbing material is delivered via mechanical stirring, sonic vibration, ultrasound, alternating suction and pressurization, or a microjet to one or more selected from the group consisting of hair follicles, sebaceous glands, sebaceous ducts, and funnels; The light-absorbing material is exposed to energy activation; The energy is light energy having a wavelength that is preferentially absorbed by a light-absorbing material, and is a type that emits heat. Composition.
  11. In item 10, a composition in which the body hair is lightly colored or thin.
  12. A composition in which body hair is prepared by the removal of follicular contents or hair removal in Clause 10.
  13. A composition according to claim 10, wherein the thickness of the gold shell is selected to reach peak absorption of light with a wavelength of 700 to 1,100 nm.

Description

Compositions and methods comprising energy-absorbing materials for follicular delivery Related application data This application claims priority to U.S. Provisional Patent Application Serial No. 61/636,381, filed April 20, 2012, and U.S. Utility Model Application Serial No. 13/789,575, filed March 7, 2013. The full contents of the aforementioned patent applications are incorporated herein by reference. The present application may contain subject matter related to that disclosed and claimed in U.S. Patent Application Publication No. 2012/0059307 A2, published on March 8, 2012, the entire contents of said application are incorporated herein by reference. Acne vulgaris is a follicular skin disease characterized by the appearance of comedones, papules, nodules, and cysts. A comedone is a hair follicle blocked by a keratin plug. Open comedones, where a keratin plug is visible, form "blackheads," while closed comedones often form "whiteheads" that progress into inflammatory papules, nodules, and cysts. The presence of bacteria in the hair follicle attracts white blood cells, which can lead to an inflammatory response manifesting as papules (red bumps), pustules, and nodules. Acne can be mild if only a few comedones or papules are present, or it can be highly inflammatory and leave unsightly scars. Improved treatment or remedial methods are required for follicular skin diseases, such as acne vulgaris. US 6685730 B2 (February 3, 2004) US 2003-0170189 Al (2003. 9. 11.) WO 2012-027728 A2 (2012. 3. 1.) As described below, the present invention provides a method for treating or improving follicular skin disease (e.g., acne) in a subject (e.g., human), a composition comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell), and a method for delivering said particles through local application to, for example, hair follicles, sebaceous ducts and/or sebaceous glands for use according to said method. Accordingly, in one aspect, the present invention provides a method for treating or improving a follicular skin disease in a subject, comprising: topically applying a formulation comprising submicron particles containing a light-absorbing material to the skin of a subject; facilitating the delivery of the material to a hair follicle, sebaceous gland, sebaceous duct, or funnel of the skin by mechanical stirring, sonic vibration, ultrasound, alternating suction and pressurization, or a microjet; and treating or improving a follicular skin disease in a subject by exposing the submicron particles to energy activation. In another aspect, the present invention provides a method for improving the appearance of enlarged pores on the skin of a subject, comprising: applying a formulation containing submicron particles containing a light-absorbing material topically to the skin of a subject; promoting the delivery of the material to hair follicles, sebaceous glands, sebaceous ducts, or funnels of the skin by mechanical stirring, sonic vibration, ultrasound, alternating suction and pressurization, or a microjet; and improving the appearance of enlarged pores on the skin of a subject by exposing the submicron particles to energy activation. In another aspect, the present invention provides a method for improving the appearance of oily skin of a subject, comprising: applying a formulation containing submicron particles containing a light-absorbing material topically to the skin of a subject; facilitating the delivery of the submicron particles to hair follicles, sebaceous glands, sebaceous ducts, or funnels of the skin by mechanical stirring, sonic vibration, ultrasound, alternating suction and pressurization, or a microjet; and improving the appearance of the oily skin of a subject by exposing the submicron particles to energy activation. Another aspect of the present invention provides a method for permanent hair removal of a subject, comprising applying a light-absorbing material topically to the skin of the subject and permanently removing the hair by exposing the material to energy activation. In one embodiment, the body hair is lightly pigmented or fine hair. In another embodiment, the method further comprises removing the body hair from the hair follicles of the subject before applying the light-absorbing material topically to the skin of the subject and exposing the material to energy activation. In another aspect, the present invention provides a method for treating hyperhidrosis by thermally damaging the eccrine gland or the surrounding area, comprising applying a light-absorbing material locally to the skin of a subject and exposing the material to energy activation to permanently remove the eccrine gland and treat hyperhidrosis. In another aspect, the present invention provides a method for promoting the delivery of a light-absorbing substance to a target volume within the skin of a subject to achieve a therapeutic effect, comprising: applying a formulation conta