KR-20260066453-A - DEVICE FOR TRANSPORTING, TRAPPING AND ESCAPING MICROPARTICLES USING SOFT MAGNETIC MICROSTRUCTURES

KR20260066453AKR 20260066453 AKR20260066453 AKR 20260066453AKR-20260066453-A

Abstract

A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure is disclosed. A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure according to one embodiment of the present invention comprises a magnetic field application unit that generates and changes a magnetic field and a soft magnetic microstructure that controls the movement of microparticles including magnetic beads according to the direction of magnetization, wherein the soft magnetic microstructure comprises a plurality of curved segments and a linear segment connecting the curved segments and is a circular structure having an internal space, and at least one of the linear segments may have different widths at both ends.

Inventors

이찬희
백서림
류동환

Assignees

주식회사 엘엠엔틱바이오텍

Dates

Publication Date: 20260512
Application Date: 20241104

Claims (9)

A magnetic field application unit that generates and changes a magnetic field; and A soft magnetic microstructure that is magnetized according to a change in the magnetic field by the magnetic field application unit and controls the movement of microparticles including magnetic beads according to the direction of magnetization; wherein The above soft magnetic microstructure is, A circular structure having an internal space, comprising a plurality of curved segments and linear segments connecting the curved segments, and A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure, wherein at least one of the linear segments has different widths at both ends.
In paragraph 1, The above soft magnetic microstructure is, A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure comprising three curved segments and three linear segments, respectively.
In paragraph 2, The above soft magnetic microstructure is, A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure, wherein a plurality of the above-mentioned soft magnetic microstructures are connected and share at least one curved segment.
In paragraph 3, The above soft magnetic microstructure is, A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure sharing at least one linear segment.
In paragraph 1, The above soft magnetic microstructure is, When the magnetic field changes in a first direction by the magnetic field application unit, the microparticles in the external space of the soft magnetic microstructure are moved in a first direction along the outer circumference of the soft magnetic microstructure, and A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure, which moves the microparticles in the outer space of the soft magnetic microstructure into the inner space when the magnetic field changes in a second direction by the magnetic field application part.
In paragraph 1, The above soft magnetic microstructure is, When the magnetic field applied by the magnetic field application unit changes in the first direction, the microparticles in the internal space of the soft magnetic microstructure are moved in the second direction along the inner circumference of the internal space, and A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure, wherein when the magnetic field changes in a second direction by the magnetic field application part, the microparticles in the internal space of the soft magnetic microstructure are moved in a first direction along the inner circumference of the internal space.
In paragraph 5, The above soft magnetic microstructure is, A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure, wherein when the magnetic field changes in a second direction by the magnetic field application unit, the microparticle is moved into the internal space through the narrower end of the two ends of a preceding segment having different widths.
In paragraph 1, The above magnetic field application unit is, A magnetic field containing a component perpendicular to the above soft magnetic microstructure is applied, and The above soft magnetic microstructure is, A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure, which moves microparticles in the internal space of the soft magnetic microstructure to the external space when the magnetic field changes by the magnetic field application part.
In paragraph 5, It further includes a current application unit, and The above soft magnetic microstructure is, A device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure, which moves microparticles in the internal space of the soft magnetic microstructure to the external space when the magnetic field changes due to the current of the current application part.

Description

Device for Transporting, Trapping, and Escaping Microparticles Using Soft Magnetic Microstructures The present invention relates to a device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure. Methods for analyzing biomolecules include immunoassay, DNA hybridization, and receptor-based analysis, which are widely used in medical diagnostics and new drug development. In these analyses, various biomolecules can be detected by utilizing the selective binding capabilities of antibodies, DNA, RNA, and molecular receptors. However, since the binding process of biomolecules cannot be directly observed, labeling substances such as fluorescent materials, radioactive materials, enzymes, and magnetic particles are used to generate measurable signals. High-sensitivity signal generation is crucial for detecting minute amounts of molecules, which contributes to saving expensive target materials and reducing costs. To this end, various high-sensitivity detection methods utilizing magnetic particles have been developed. For example, there are methods for detecting DNA by immobilizing it on a Giant Magneto-Resistive (GMR) device and using magnetic particles as labeling materials, or methods for measuring the magnetic susceptibility of magnetic particles using a Superconducting Quantum Interferometer (SQUID). However, since these systems require the direct measurement of the magnetic field of magnetic particles, there was a problem in that they could not be miniaturized due to the complexity and high cost of the equipment. In addition, the planar array method, which analyzes receptor molecules by immobilizing them on a planar substrate, had limitations in multiple detection and simplification of the sample preparation process. Biomolecular transport technology lacks sufficient control at the nanoscale, and expensive systems can generate heat that damages biological organisms. Furthermore, conventional magnetic tweezers and micro-needles possess only a single tip, limiting them to transporting only a single magnetic medium, and there were still limitations in moving groups of closely located mediums. Subsequently, technologies utilizing magnetophoresis, magnetic structures, and magnetic beads emerged to transport or separate biomolecules at the single-cell level, but there is still significant room for improvement in terms of efficiency and accuracy. As an example of the technology forming the background of the present invention, Korean Registered Publication No. 10-1067695 (registration date September 20, 2011) discloses a molecular transport system using a soft magnetic microstructure comprising a magnetic force generating means for controlling an external magnetic field, a soft magnetic microstructure for controlling the movement of micro beads, and micro beads fixed to the surface of a biomolecule and having their movement controlled by a magnetic field. FIG. 1 is a soft magnetic microstructure of a device for transporting, trapping, and escaping microparticles using a soft magnetic microstructure according to one embodiment of the present invention. FIG. 2 shows the movement of microparticles when a magnetic field changing in a first direction is applied to a soft magnetic microstructure according to one embodiment of the present invention. FIG. 3 illustrates the movement of microparticles when a magnetic field changing in a second direction is applied to a soft magnetic microstructure according to one embodiment of the present invention. FIG. 4 is a graph of the conditions for moving microparticles into the internal space of a soft magnetic microstructure according to one embodiment of the present invention. FIG. 5 shows that when a magnetic field perpendicular to a soft magnetic microstructure according to one embodiment of the present invention is applied, microparticles in the internal space move to the external space. Figure 6 shows that when an electric current is applied to a soft magnetic microstructure according to one embodiment of the present invention, microparticles in the internal space move to the external space. FIG. 7 is a plurality of soft magnetic microstructures sharing a curved segment according to one embodiment of the present invention. FIG. 8 is a plurality of soft magnetic microstructures sharing a curved segment and a linear segment according to one embodiment of the present invention. FIG. 9 is a soft magnetic microstructure according to another embodiment of the present invention. The operating principles of preferred embodiments of the present invention will be described in detail below with reference to the attached drawings. Furthermore, in describing embodiments of the invention, detailed descriptions of related known functions or configurations will be omitted if it is determined that such detailed descriptions could obscure the essence of the present disclosure. Additionally, the terms used below are defined considering their functions in the pres