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KR-20260066610-A - Incise Drape and manufacturing method thereof

KR20260066610AKR 20260066610 AKR20260066610 AKR 20260066610AKR-20260066610-A

Abstract

The present invention provides a surgical drape comprising: a substrate layer; and an adhesive layer comprising acid-treated chitosan, povidone iodine, and an acrylate copolymer, wherein the adhesive layer contains less than 1 part by weight of povidone iodine and the acid-treated chitosan contains 1.5 to 5 parts by weight relative to the povidone iodine, thereby providing a surgical drape that can exhibit high antibacterial activity while minimizing skin irritation by including povidone iodine at a low concentration.

Inventors

  • 정민호

Assignees

  • 주식회사 엔도비전

Dates

Publication Date
20260512
Application Date
20250623
Priority Date
20241104

Claims (11)

  1. Substrate layer; and A surgical drape comprising an adhesive layer formed on the above substrate layer, the adhesive layer comprising acid-treated chitosan, povidone iodine, and an acrylate copolymer; A surgical drape, wherein the adhesive layer contains povidone iodine in an amount of 0.7 to less than 1 part by weight based on the total weight of the adhesive layer, and acid-treated chitosan is contained in an amount of 1.5 to 5 parts by weight relative to the povidone iodine.
  2. In paragraph 1, The above chitosan is a surgical drape comprising mushroom-derived chitosan.
  3. In paragraph 2, A surgical drape comprising the above mushroom-derived chitosan with a molecular weight of 3,000 to 30,000.
  4. In paragraph 1, A surgical drape comprising one or more selected from the group consisting of vinyl acrylate copolymer, methacrylate copolymer, sterine acrylate copolymer, butacrylate copolymer, alkyl acrylate copolymer, acrylic acid and acrylate copolymer, acrylate-polyester copolymer, acrylate-polyurethane copolymer, and acrylate-silicone copolymer.
  5. In paragraph 1, A surgical drape comprising a polyurethane layer formed on a polyolefin film, wherein the above-mentioned substrate layer comprises a polyurethane layer formed on a polyolefin film.
  6. In paragraph 1, The above surgical drape is a surgical drape comprising release paper on one or both sides.
  7. S1) Step of preparing the substrate layer; S2) A step of mixing acid-treated chitosan, povidone iodine, and acrylate copolymer and applying the mixture to the substrate layer to form an adhesive layer; and S3) a drying step; comprising, wherein the acid-treated chitosan: povidone iodine: acrylate copolymer is mixed in a weight ratio of 0.1 to 5: 0.1 to 10: 75 to 99, a method for manufacturing a surgical drape.
  8. In the seventh, A method for manufacturing a surgical drape, wherein step S1) comprises the step of forming a substrate layer by applying 40 to 60 mL of polyurethane per 1 m² of polyolefin film.
  9. In the seventh, The above step S2) S2-1) A step of preparing a mixed solution by mixing acid-treated chitosan, povidone iodine, and acrylate copolymer and stirring at 30 to 40 ℃ for 80 to 100 minutes; S2-2) A step of heating the above mixed solution to 70 to 90 ℃ and mixing for 50 to 90 minutes; and S2-3) A step of forming an adhesive layer by cooling to 30 to 40 ℃ and stirring for 1 to 10 hours, and then applying 80 to 110 mL per 1 m² of the substrate layer; comprising a method for manufacturing a surgical drape.
  10. In Paragraph 7, A method for manufacturing a surgical drape comprising immersing mushroom-derived chitosan in an acidic solution to prepare an acid-treated chitosan mixture, washing the acid-treated chitosan with at least one of alcohol and a surfactant, and then drying it.
  11. In Paragraph 7, A method for manufacturing a surgical drape, wherein the above acrylate copolymer comprises one or more selected from the group consisting of vinyl acrylate copolymer, methacrylate copolymer, sterine acrylate copolymer, butacrylate copolymer, alkyl acrylate copolymer, acrylic acid and acrylate copolymer, acrylate-polyester copolymer, acrylate-polyurethane copolymer, and acrylate-silicone copolymer.

Description

Surgical Drape and Manufacturing Method Thereof The present invention relates to a surgical drape with enhanced antibacterial activity and a method for manufacturing the same. During surgical procedures, surgical drapes are used to protect the area around the incision from infection and the like. Generally, a surgical drape comprises a base layer and an adhesive surface formed on one side of the base layer. It includes. A surgical drape having this composition has an adhesive surface that adheres to the skin and is incised together with the skin by a surgical instrument. The purpose of using surgical drapes is to reduce the penetration of germs and bacteria into the incision site. During surgical preparation, the skin is generally not sterilized but only disinfected; consequently, bacteria remain on the skin and can transfer to the incision site during the procedure. Therefore, using surgical drapes can reduce infection at the surgical site by immobilizing microorganisms remaining on the skin and providing continuous antimicrobial action. Additionally, by fixing the skin to stabilize the incision site, it is possible to prevent the incision from opening or damaging the underlying tissue. Surgical drapes primarily use povidone iodine or chlorhexidine to exhibit antibacterial properties. Chlorhexidine exhibits high antibacterial activity against germs and bacteria with low skin irritation, so it is used instead of or in combination with povidone iodine; however, it has the disadvantage of not being able to exert antibacterial action against viruses or fungi when used alone. Povidone iodine exhibits broad-spectrum antibacterial activity against germs, viruses, and fungi, and due to its strong bactericidal power and rapid rate of action, it can deliver a powerful sterilization effect within seconds to minutes, making it widely used in various fields such as disinfection, wound care, and sterilization of medical instruments. The antibacterial action and uses of povidone iodine vary depending on its concentration. At low concentrations, it does not exhibit a strong antibacterial effect, causing minimal skin irritation and leaving no residue after use, thus not hindering wound healing; therefore, it is used for wound healing patches, wound dressings, or skin disinfectants. At high concentrations, it can exhibit a strong antibacterial effect and is used to disinfect surgical drapes or medical devices to prevent surgical site infections. However, using povidone iodine at high concentrations can irritate the skin, and long-term use may lead to side effects such as burns or cytotoxicity. In the case of surgical drapes, high concentrations of povidone iodine must be used to enhance antibacterial effects because they are applied directly to the skin. However, as mentioned above, long-term use of high concentrations of povidone iodine can cause skin irritation such as dryness, redness, or stinging. Furthermore, due to its strong antibacterial action, it can be toxic to both bacteria and normal cells, leading to slow wound healing if it penetrates open wounds or incisions. Additionally, some patients have shown allergic reactions to iodine. To address this problem, various attempts have been made to achieve high antibacterial activity while maintaining a low concentration of povidone iodine by mixing it with other antimicrobial agents; however, it has not been possible to reduce the concentration of povidone iodine to a low level (less than 1%) that minimizes skin irritation. Consequently, surgical drapes still contain high concentrations of povidone iodine, posing a risk of skin irritation and skin inflammation. Therefore, there is a need to develop surgical drapes that exhibit high antibacterial activity even when containing low concentrations of povidone iodine and minimize skin irritation. FIG. 1 shows a surgical drape according to one embodiment of the present invention. FIG. 2 shows a surgical drape according to another embodiment of the present invention. FIG. 3 shows a surgical drape according to another embodiment of the present invention. The present invention is capable of various modifications and may have various embodiments; specific embodiments are illustrated in the drawings and described in detail in the detailed description. However, this is not intended to limit the present invention to specific embodiments, and it should be understood that it includes all modifications, equivalents, and substitutions that fall within the spirit and scope of the present invention. In describing the present invention, detailed descriptions of related prior art are omitted if it is determined that such detailed descriptions may obscure the essence of the present invention. Terms such as "first," "second," etc., may be used to describe various components, but said components should not be limited by said terms. These terms are used solely for the purpose of distinguishing one component from another. The terms used in this