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KR-20260066810-A - COMPOSITIONS FOR IMPROVING LEAN BODY MASS, BROWN ADIPOSE TISSUE AND FOR INHIBITING ADVANCED GLYCATION END PRODUCTS

KR20260066810AKR 20260066810 AKR20260066810 AKR 20260066810AKR-20260066810-A

Abstract

A synergistic herbal composition comprising a combination of extracts, fractions, or phytochemicals derived from Moringa oleifera, Murraya koenigii, and Curcuma longa, or a mixture thereof, for increasing lean body mass and brown adipose tissue; accelerating the conversion of white adipose tissue ( WAT ) to brown adipose tissue (BAT); and inhibiting disease conditions associated with the overproduction of advanced glycation products ( AGEs ) and increased levels of advanced glycation products ( AGEs ). The present invention also provides a method for increasing lean body mass and brown adipose tissue in mammals; accelerating the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT); and inhibiting disease conditions associated with the overproduction of advanced glycation products (AGEs) and increased levels of advanced glycation products (AGEs).

Inventors

  • 고카라주 강가 라주
  • 고카라주 라마 라주
  • 골라코티 트리머르툴루
  • 치라부리 벤카테스와라 라오
  • 소메팔리 벤카테스왈루
  • 부파티라주 키란

Assignees

  • 피.엘. 토마스-라일라 뉴트라슈티컬스, 인크.

Dates

Publication Date
20260512
Application Date
20181016
Priority Date
20171016

Claims (12)

  1. A synergistic herbal food composition for increasing lean body mass and reducing fat mass, comprising a combination of Moringa oleifera extract, Murraya koenigii extract, and Curcuma longa extract standardized to 95% total curcuminoids; The above curry tree extract is extracted with 60% aqueous ethanol, 80% aqueous ethanol, or water; and the above Moringa oleifera extract is extracted with 90% aqueous ethanol, 75% aqueous ethanol, 50% aqueous ethanol, methanol, or water; The above composition is a synergistic herbal food composition that increases brown adipose tissue, accelerates the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT), and inhibits the overproduction of advanced glycation end products (AGEs).
  2. In paragraph 1, A synergistic herbal food composition in which the weight of a component derived from Moringa oleifera varies in the range of 10% to 90%, the weight of a component derived from Curry tree varies in the range of 10% to 90%, and the weight of a component derived from Turmeric varies in the range of 5% to 30%.
  3. In paragraph 2, A synergistic herbal food composition in which the weight of a component derived from Moringa oleifera varies in the range of 30% to 80%, the weight of a component derived from Curry tree varies in the range of 10% to 60%, and the weight of a component derived from Turmeric varies in the range of 5% to 20%.
  4. In paragraph 1, A synergistic herbal food composition optionally comprising at least one component selected from pharmaceutically, nutraceutically, and dietaryly acceptable excipients, carriers, and diluents.
  5. In paragraph 4, Pharmaceutically, nutraceuticalally, or dietaryally acceptable excipients, carriers, and diluents include glucose, fructose, sucrose, maltose, sucralose, aselpham K, yellow dextrin, white dextrin, aerosil, microcrystalline cellulose, nucillin, calcium stearate, magnesium stearate, sorbitol, stevioside, monoammonium glycyrrhizinate, sodium alginate, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl-alpha-tocopherol, glycerin, propylene glycol, glycerin fatty esters, polyglycerin fatty esters, sucrose fatty esters, sorbitan fatty esters, propylene glycol fatty esters, acacia, carrageenan, casein, gelatin, pectin, agar, B vitamins, nicotinamide, calcium A synergistic herbal food composition selected from pantothenate, amino acids, proteins, calcium salts, pigments, flavorings, preservatives, distilled water, brine, aqueous glucose solution, alcohol, propylene glycol and polyethylene glycol, animal and vegetable oils, white soft paraffin, paraffin, flavorings, colorings, and waxes.
  6. In paragraph 4, A synergistic herbal food composition that can be formulated into a dosage form selected from dry powder, liquid, beverage, food, dietary supplement, tablet, capsule, soft chew tablet, or controlled-release tablet using a controlled-release polymer-based coating by techniques including nanotechnology, microencapsulation, and colloidal carrier systems.
  7. In paragraph 4, A synergistic herbal food composition that can be formulated as a nutritional/dietary supplement that can be considered/manufactured as a dosage form of a health food or special health food, or as a solid food, chocolate or nutritional bar, semi-solid food, cream, jam or gel, or beverage, soft drink or probiotic drink, drop, candy, soft chewable or gummy bear, chewing gum, gummy candy, yogurt, ice cream, pudding, soft red bean jelly, jelly, cookie, tea, soft drink, juice, milk, coffee, cereal, or snack bar.
  8. In paragraph 1, A synergistic herbal food composition in which the extract is obtained from at least one plant part selected from the group comprising leaves, stems, soft stems, above-ground parts, fruits, fruit peels, seeds, flower heads, roots, tree bark, rhizomes, or whole plants or mixtures thereof.
  9. In paragraph 1, A synergistic herbal food composition produced using at least one solvent selected from the group comprising turmeric extract, C1-C5 alcohols, ethanol, methanol, n-propanol, or isopropyl alcohol; ketones, acetone, methyl isobutyl ketone, or water and mixtures thereof; chlorinated solvents or methylene dichloride and chloroform and mixtures thereof; C1-C7 hydrocarbons or hexane; esters or ethyl acetate and mixtures thereof.
  10. In Paragraph 9, A synergistic herbal food composition in which turmeric extract is selected from aqueous extracts, alcoholic extracts, and hydroalcoholic extracts.
  11. In paragraph 1, A synergistic herbal food composition comprising a combination of Moringa oleifera extract; curry tree extract and turmeric extract in a weight ratio selected from the group consisting of 6:3:1; 8:1:1; 4:5:1; 2:2:1; 3:6:1 and 6:3.5:0.5.
  12. A method for inhibiting the increase in lean body mass and brown adipose tissue, the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT), and the overproduction of advanced glycation end products (AGEs) in mammals excluding humans, comprising a combination of Moringa oleifera extract, Curry tree extract, and Turmeric extract standardized to 95% total curcuminoids in doses suitable for said mammals excluding humans, and optionally supplementing with a synergistic composition containing at least one additional component selected from pharmaceutically, nutraceutically, and dietaryly acceptable excipients, diluents, and carriers. A method wherein the above curry tree extract is extracted with 60% aqueous ethanol, 80% aqueous ethanol, or water; and the above Moringa oleifera extract is extracted with 90% aqueous ethanol, 75% aqueous ethanol, 50% aqueous ethanol, methanol, or water.

Description

Compositions for improving lean body mass, brown adipose tissue, and inhibiting advanced glycation end products The present invention relates to a synergistic composition comprising a combination of extracts or fractions derived from Moringa oleifera, Murraya koenigii, and Curcuma longa, or phytochemicals or mixtures thereof, for increasing lean body mass and brown adipose tissue; accelerating the conversion of white adipose tissue ( WAT ) to brown adipose tissue ( WAT ); inhibiting the overproduction of advanced glycation end products ( AGEs ) and treating disease conditions associated with advanced glycation end products (AGEs). The present invention also relates to a method for increasing lean body mass and brown adipose tissue in a mammal requiring said synergistic composition by supplementing said composition with said composition; a method for converting white adipose tissue (WAT) to brown adipose tissue (WAT); a method for inhibiting the overproduction of advanced glycation end products (AGEs); and a method for treating disease conditions associated with advanced glycation end products (AGEs). Lean body mass is the amount of muscle mass in the body, independent of fat, bone, and other parts. Food supplements based on protein, amino acids, and micronutrients, as well as other approaches to increase muscle mass, are gaining great popularity among athletes and bodybuilders. As athletes continue to strive for improved performance, there is a constant need for newer and more effective supplements to help increase lean body mass, muscle size, and/or strength. While adipose tissue is best known for its role in fat storage, it can also suppress weight gain and metabolic diseases through the action of specialized thermogenic adipocytes. These tissues are referred to as brown adipocytes, which are located in dedicated depots and inherently express high levels of thermogenic genes. Additionally, there exists another form called inducible 'brown-type' adipocytes (also known as beige cells), which develop within white adipose tissue in response to various activators. Both brown and beige adipocytes reduce metabolic diseases and are associated with leanness in humans. Numerous genes and pathways regulating brown and beige adipocyte biology have been identified, providing various promising therapeutic targets for metabolic diseases. Advanced Glycation Products (AGEs) (also known as glycotoxins) are a diverse group of highly active oxidized compounds formed by non-enzymatic reactions between reducing sugars and free amino groups of proteins, lipids, or nucleic acids, which are known as the Maillard or browning reaction. AGEs are formed during normal metabolism and become pathogenic when high levels of AGEs accumulate in tissues and circulation. AGEs play a role in the development and exacerbation of complications in the progression of diabetes, atherosclerosis, the normal aging process, arthritis, cancer, and age-related neurodegenerative diseases such as Alzheimer's disease. US2004023889Al discloses a food supplement composition comprising alpha-lipoic acid or its derivatives and amino acids. US'889 also discloses a method of using the aforementioned composition to increase lean body mass and/or muscle size and/or strength in individuals, particularly athletes. US20040077556 Al discloses a composition for promoting body weight loss, thermogenesis, increased metabolism, boosting energy levels, promoting appetite suppression, and promoting lean muscle mass in mammals, comprising an effective amount of epigallocatechin gallate; caffeine and l-tyrosine. US9420808B2 discloses a composition and method for increasing lean muscle mass and/or decreasing fat gain in a growing animal by supplying the composition having a total lysine to metabolizable energy ratio of about 2.5 to about 6 g/Mcal and comprising (a) arginine in a total arginine to total lysine ratio of about 1.1 to about 1.6; (b) isoleucine in a total isoleucine to total lysine ratio of about 0.8 to about 1.3; (c) leucine in a total leucine to total lysine ratio of about 1.8 to about 3.0; (d) valine in a total valine to total lysine ratio of about 0.8 to about 1.4; and (e) methionine and cystine in a total methionine + cystine ratio of about 0.8 to about 1.7. EP2500361B1 discloses an isolated protein that binds to a RAGE protein, in particular a monoclonal antibody, in particular a CDR-grafted humanized antibody. Specifically, the antibody has the ability to inhibit the binding of RAGE to its various ligands. US2017182107Al discloses a composition of cinnamon branches and peony bark, cinnamon branches and peony root, or cinnamon branches and Poria cocos for inhibiting the overproduction of said end-glycation products, which occurs under a chronic diabetic state and exhibits the effect of fragmenting the cross-linking between the end-glycation product and the substrate protein. US 8541383 B2 discloses a synergistic anti-adipogenic and pro-lipolytic composition for