KR-20260066946-A - Method for Diagnosing Alzheimer's Disease with Improved Convenience

KR20260066946AKR 20260066946 AKR20260066946 AKR 20260066946AKR-20260066946-A

Abstract

A method for diagnosing the possibility of Alzheimer's disease with improved convenience is disclosed. According to one aspect of the present embodiment, an Alzheimer's diagnostic system provides a method for diagnosing Alzheimer's disease in a subject, comprising: an irradiation process of irradiating light onto the left and right prefrontal lobes of the patient; a light reception process of receiving reflected light reflected from each prefrontal lobe irradiated in the irradiation process; an analysis process of analyzing the activity level of each prefrontal lobe of the subject by analyzing the reflected light received in the light reception process; and a diagnostic process of diagnosing the possibility of Alzheimer's disease in the subject based on whether a prefrontal lobe is activated in response to a scent provided to the subject.

Inventors

김재원
김성철

Assignees

주식회사 엔서

Dates

Publication Date: 20260512
Application Date: 20241105

Claims (10)

In the Alzheimer's diagnostic system, An Alzheimer's testing device attached to a pre-set area of a subject smelling a scent, which tests the activity of the left prefrontal cortex and the right prefrontal cortex caused by olfactory stimulation; and An Alzheimer's diagnostic device that diagnoses a subject's likelihood of having Alzheimer's based on whether or not a specific prefrontal cortex is activated, by analyzing the results of the test performed by the above-mentioned Alzheimer's testing device. An Alzheimer's diagnostic system characterized by including
In paragraph 1, The above-mentioned pre-set area is, An Alzheimer's diagnostic system characterized by the subject's glabella.
In paragraph 1, The above Alzheimer's testing device is, An Alzheimer's diagnostic system characterized by not requiring any compliance conditions from the subject when conducting the test.
In paragraph 1, The above Alzheimer's testing device is, An Alzheimer's diagnostic system characterized by including a first connector connected to the above-mentioned Alzheimer's diagnostic device.
In paragraph 4, The above Alzheimer's diagnostic device is, A second connector that is coupled complementarily to the first connector; and An Alzheimer's diagnostic system characterized by including an analysis unit that analyzes the activity of the left prefrontal cortex and the right prefrontal cortex from the test results of the above-mentioned Alzheimer's testing device and diagnoses the possibility of Alzheimer's disease in the subject based thereon.
In paragraph 5, The above analysis unit is, An Alzheimer's diagnostic system characterized by deriving the hemoglobin concentration in each prefrontal cortex of a subject.
In paragraph 6, The above analysis unit is, An Alzheimer's diagnostic system characterized by deriving the concentrations of oxyhemoglobin and deoxyhemoglobin from the sensing values sensed by each light receiving unit.
In Paragraph 7, The above analysis unit is, An Alzheimer's diagnostic system characterized by analyzing the tissue activity of each prefrontal cortex using the difference in hemoglobin concentration.
In paragraph 8, The above analysis unit is, An Alzheimer's diagnostic system characterized by diagnosing the likelihood of Alzheimer's disease in a subject based on whether the right prefrontal cortex or the left prefrontal cortex is activated.
In paragraph 5, The above Alzheimer's diagnostic device is, An Alzheimer's diagnostic system characterized by further including an output unit that outputs to the outside the activity of each prefrontal cortex of a subject and the likelihood of Alzheimer's derived by the analysis unit above.

Description

Method for Diagnosing Alzheimer's Disease with Improved Convenience This embodiment relates to a method for diagnosing the possibility of Alzheimer's disease with improved convenience. The content described in this section merely provides background information regarding the present embodiment and does not constitute prior art. Dementia is a pathological phenomenon that must be distinguished from normal aging, and depending on its cause, it is classified into Alzheimer's dementia, vascular dementia, and dementia resulting from alcoholism, trauma, or the sequelae of Parkinson's disease. Among these, the toxicity of the neurotoxic protein beta-amyloid is suggested to be the most important cause of the pathogenesis of Alzheimer's dementia. Accordingly, conventionally, to diagnose the possibility of Alzheimer's disease in patients, brain PET-CT scans have been performed to determine the extent of beta-amyloid deposition in the cerebrum and cerebellum. In other words, the examination has traditionally been conducted by having the patient ingest a contrast agent and having the PET-CT scanner image the patient's head. However, the conditions that patients must comply with for the brain PET-CT scan were quite stringent, such as fasting for a certain period or consuming a significant amount of fluids to ingest the contrast agent. Consequently, while this did not cause significant inconvenience for typical adults, patients such as the elderly have faced difficulties undergoing conventional PET-CT scans. FIG. 1 is a diagram illustrating the configuration of an Alzheimer's diagnostic system according to one embodiment of the present invention. FIG. 2 is a diagram illustrating the configuration of an Alzheimer's disease testing device according to one embodiment of the present invention. FIG. 3 is a diagram illustrating the configuration of an Alzheimer's diagnostic device according to a first embodiment of the present invention. Figure 4 is a graph showing the diagnostic results of a general subject and an Alzheimer's disease-diagnosed subject according to one embodiment of the present invention. FIG. 5 is a diagram illustrating the configuration of an Alzheimer's diagnostic device according to a second embodiment of the present invention. FIG. 6 is a flowchart illustrating a method for an Alzheimer's diagnostic system according to one embodiment of the present invention to diagnose Alzheimer's disease in a subject. The present invention is susceptible to various modifications and may have various embodiments, and specific embodiments are illustrated in the drawings and described in detail. However, this is not intended to limit the invention to specific embodiments, and it should be understood that the invention includes all modifications, equivalents, and substitutions that fall within the spirit and scope of the invention. Similar reference numerals have been used for similar components in the description of each drawing. Terms such as first, second, A, B, etc., may be used to describe various components, but said components should not be limited by said terms. These terms are used solely for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be named the second component, and similarly, the second component may be named the first component. The term "and/or" includes a combination of a plurality of related described items or any of a plurality of related described items. When it is stated that one component is "connected" or "connected" to another component, it should be understood that while it may be directly connected or connected to that other component, there may also be other components in between. On the other hand, when it is stated that one component is "directly connected" or "directly connected" to another component, it should be understood that there are no other components in between. The terms used in this application are used merely to describe specific embodiments and are not intended to limit the invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In this application, terms such as "comprising" or "having" should be understood as not precluding the existence or addition of the features, numbers, steps, actions, components, parts, or combinations thereof described in the specification. Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as generally understood by those skilled in the art to which this invention pertains. Terms such as those defined in commonly used dictionaries should be interpreted as having meanings consistent with their meanings in the context of the relevant technology, and should not be interpreted in an ideal or overly formal sense unless explicitly defined in this application. In addition, each component, process, procedure, or method included in each emb