KR-20260067059-A - Nanocomposite particles comprising zinc oxide coated with layered double hydroxide and polydopamine and uses thereof

Abstract

The present invention relates to a nanocomposite particle comprising zinc oxide (ZnO) coated with LDH (layered double hydroxide) and polydopamine and its use. By confirming that a nanocomposite particle prepared by double-coating zinc oxide with LDH and polydopamine has a superior UV blocking effect compared to a nanoparticle comprising one or two of the three materials, it can be usefully utilized as a sunscreen.

Inventors

• 이종현
• 김한비
• 곽민수
• 허현영

Assignees

• 가톨릭대학교 산학협력단

Dates

Publication Date

20260512

Application Date

20241105

Claims (10)

1. Nanocomposite particles comprising zinc oxide (ZnO) coated with a layered double hydroxide (LDH) structure and polydopamine.
2. The nanocomposite particle according to claim 1, characterized in that the nanocomposite particle is prepared by coating a zinc oxide-double-layer hydroxide structure composite, prepared by coating zinc oxide with a double-layer hydroxide structure, with polydopamine.
3. A nanocomposite particle according to claim 1, characterized in that the double-layer hydroxide structure is a porous double-layer hydroxide structure.
4. A nanocomposite particle according to claim 1, characterized in that the double-layered hydroxide structure is a double-layered hydroxide (Mg-Al layered double hydroxide) of a magnesium-aluminum composition containing carbonate ions.
5. A nanocomposite particle according to claim 1, characterized in that the polydopamine is included in an amount of 20 to 400 parts by weight per 100 parts by weight of the double-layer hydroxide structure.
6. A nanocomposite particle according to claim 1, characterized in that the nanocomposite particle exhibits an ultraviolet blocking effect.
7. The nanocomposite particle according to claim 1, characterized in that the average diameter of the nanocomposite particle is 200 to 1000 nm.
8. A nanocomposite particle according to claim 1, characterized in that the nanocomposite particle further comprises titanium dioxide ( TiO2 ).
9. A step of preparing a zinc oxide-layered double hydroxide structure composite by coating zinc oxide (ZnO) with a layered double hydroxide (LDH) structure (Step 1); and A method for manufacturing a nanocomposite particle of claim 1, comprising the step (step 2) of coating the zinc oxide-double layer hydroxide structure composite of the first step with polydopamine.
10. A cosmetic composition for UV protection comprising the nanocomposite particles of claim 1 as an active ingredient.

Description

Nanocomposite particles comprising zinc oxide coated with layered double hydroxide and polydopamine and uses thereof The present invention relates to a nanocomposite particle comprising a layered double hydroxide structure (hereinafter referred to as LDH) and zinc oxide (ZnO) coated with polydopamine, and the use thereof. Ultraviolet rays are one of the invisible energy waves coming from the sun; while they help produce Vitamin D, which is essential for our lives, excessive exposure can cause serious health problems such as skin cancer, premature aging, and cataracts. Various types of sunscreen products have been developed to protect humans from these issues. Currently, sunscreen products can be classified into two types based on their mode of action. The first type, physical sunscreens, works by physically reflecting ultraviolet rays by forming a film on the skin surface using inorganic ingredients such as zinc oxide (hereinafter referred to as ZnO) and titanium dioxide (hereinafter referred to as TiO2 ). While their advantage is low skin irritation, they have disadvantages such as poor texture, a white cast, and strong absorption into the skin, which can generate free radicals and cause skin irritation when exposed to strong ultraviolet rays. The second type of chemical sunscreen works by using organic ingredients such as benzophenone-3, avobenzone, and octocrylene to convert UV energy absorbed by the skin into thermal energy and release it. Its advantages include high skin penetration, a transparent and lightweight feel, minimal accumulation of impurities in pores, and the absence of a white cast; however, its disadvantages include allergy induction, high skin irritation, and environmental issues such as water pollution. Therefore, research is currently underway on alternative ingredients that offer excellent UV protection without causing side effects or environmental pollution. Figure 1 is a nanocomposite particle for UV blocking prepared according to Experimental Example 3 below. Figure 2 is the result of analyzing the UV blocking effect of the above nanocomposite particles according to the amount of dopamine (hereinafter referred to as DA). Figure 3 shows the results of analyzing the color change of the nanocomposite particles according to the amount of DA. (a); P1 LDH, (b); LDH@PDA (0.4g DA added), (c); LDH@PDA (1.2g DA added), and (d); LDH@PDA (2.0g DA added). Figure 4 shows the results of analyzing the UV blocking effect of the above nanocomposite particles according to the core material. Figure 5 shows the results of analyzing the color change of the nanocomposite particles according to whether or not they are coated with DA. (a); ZnO, (b) ZnO@PDA, (c); TiO2 and (d); TiO2 @PDA. Figure 6 shows the results of analyzing the UV blocking effect of nanocomposite particles according to the core material. Figure 7 shows the results of analyzing the color change of the nanocomposite particles according to whether or not DA coating is applied. (a); ZnO@P-LDH, (b); ZnO@P-LDH@PDA, (c); P-LDH, (d); P-LDH@PDA, (e); synthetic plate LDH, (f); synthetic plate LDH@PDA, (g); P1 LDH and (h); P1-LDH@PDA. Figure 8 shows the results of analyzing the UV blocking effect of nanocomposite particles according to the combination of core materials. Figure 9 shows the results of analyzing the color change of nanocomposite particles according to the core material combination (a–c); and microscopic images of the nanocomposite particles (d–f). (a); ZnO, (b); ZnO@PDA, (c); ZnO@P-LDH@PDA, (d); ZnO@P-LDH (electron microscope image), (e); ZnO@P-LDH (transmission electron microscope image), and (f); ZnO@P-LDH@PDA (electron microscope image). The present invention will be described in more detail below. The present invention provides a nanocomposite particle comprising a layered double hydroxide (LDH) structure and zinc oxide (ZnO) coated with polydopamine. The above nanocomposite particles may be prepared by coating a zinc oxide-double-layer hydroxide structure composite, prepared by coating zinc oxide into a double-layer hydroxide structure, with polydopamine. The above double-layer hydroxide structure may be a porous double-layer hydroxide structure (LDH), and the porous LDH is a porous clay that forms a three-dimensional structure of a nanoplate by processing during the synthesis stage of LDH, which is an eco-friendly nanoclay, and has a hydrangea flower shape or a star shape structure. The above-mentioned polydopamine (hereinafter referred to as PDA) is a biodegradable polymer synthesized using DA (dopamine), the smallest monomer that possesses both catechol and amine, which are important chemical functional groups exhibiting visible light absorption and adhesion in the adhesive proteins of mussels. The DA molecules can penetrate into the interior of nanometer-sized three-dimensional pores and adhere evenly to the surface. DA is a neurotransmitter produced from tyrosine through an enzymatic reaction and converted into dopaquinone t