KR-20260067407-A - Cosmetic composition for enhancing or improving skin barrier function and pharmaceutical composition for preventing or treating skin barrier dysfunction

Abstract

The present invention relates to a cosmetic composition for strengthening or improving skin barrier function and a pharmaceutical composition for preventing or treating skin barrier dysfunction. The extracts of Artemisia capillaris, Platycodon grandiflorus, mulberry leaves and/or Perilla frutescens according to the present invention act as PPAR-α ligands to promote the differentiation of keratinocytes, thereby strengthening or improving skin barrier function and, furthermore, can be utilized to prevent or treat skin barrier dysfunction such as atopic dermatitis.

Inventors

• 전주희
• 박병규
• 조윤기
• 김현수

Assignees

• 주식회사 엑티브온

Dates

Publication Date

20260513

Application Date

20241104

Claims (5)

1. A cosmetic composition for strengthening or improving skin barrier function, comprising as an active ingredient an extract obtained from one or more selected from the group consisting of Artemisia capillaris, Platycodon grandiflorus, Morus alba leaves, and Perilla frutescens.
2. In claim 1, A cosmetic composition in which the above extract is a supercritical extract.
3. In claim 1, The above cosmetic composition is a cosmetic composition having PPAR-α activity promotion, keratinocyte outer membrane formation, and antioxidant efficacy.
4. A pharmaceutical composition for the prevention or treatment of skin barrier dysfunction comprising extracts of Artemisia capillaris, Platycodon grandiflorus, Morus alba leaves, and Perilla frutescens as active ingredients.
5. In claim 4, A pharmaceutical composition wherein the above skin barrier dysfunction is one or more selected from the group consisting of skin aging, inflammatory skin diseases, autoimmune skin diseases, hypertrophic scars, and keloids.

Description

Cosmetic composition for enhancing or improving skin barrier function and pharmaceutical composition for preventing or treating skin barrier dysfunction The present invention is the result of the local government-university cooperation-based regional innovation project conducted in 2024 with funding from the Ministry of Education and support from the National Research Foundation of Korea (2021RIS-001). The present invention relates to a cosmetic composition for strengthening or improving skin barrier function, and a pharmaceutical composition for preventing or treating skin barrier dysfunction. The skin is composed of the dermis and the epidermis. The epidermis is located at the outermost layer of the skin and functions as a defense against various external physical, chemical, and mechanical stimuli, as well as a protective function that prevents excessive loss of body moisture through the skin, through the normal formation and maintenance of the stratum corneum, which consists of keratinocytes. Keratinocytes formed as basal cells, which continuously proliferate in the lowest layer of the epidermis (stratum basale), undergo gradual changes in form and function while migrating to the stratum corneum. After a certain period, these keratinocytes slough off from the skin, and new keratinocytes rising from the lowest layer take over their function, repeating the process of epidermal differentiation or keratinization. During this keratinization process, keratinocytes produce Natural Moisturizing Factor (NMF) and intercellular lipids such as ceramides, cholesterol, and fatty acids. As a result, the stratum corneum acts as a barrier against the external environment, thereby possessing the function of a skin barrier. Skin dryness, considered one of the major ailments of modern society, is being identified as being primarily caused by abnormalities in skin barrier function. Conditions involving dry and sensitive skin are on the rise due to various factors, including environmental pollution, the increasing prevalence of dry environments such as apartments and high-rise buildings, rising social stress, Korea's unique culture of excessive bathing, atopic dermatitis, and aging; most cases require treatment. Consequently, extensive research has been conducted to maintain adequate skin hydration by supplying moisture from external sources or minimizing internal water loss. In fact, moisturizers utilizing ceramides or their derivatives, which possess water-retaining capabilities, have been developed and are widely used in the cosmetics industry. However, most of these products fail to demonstrate sufficient efficacy, serving only as temporary symptom relief rather than a fundamental cure. Therefore, there is an urgent need to develop substances that fundamentally regenerate damaged skin barriers. It is known that when PPAR (Peroxisome Proliferator Activated Receptor) present in keratinocytes binds to its ligand and becomes activated, it promotes the differentiation of keratinocytes and has the effect of reconstructing the damaged skin barrier. PPAR-α, a component of PPAR, plays a crucial role in the regulation of cell proliferation and differentiation, as well as in the control of inflammatory mediators. It has also been reported to play an important role in the metabolic regulation of glucose, lipids, and hormones. In particular, it has been revealed that it performs a vital role in maintaining skin homeostasis by promoting keratinocyte differentiation and inhibiting proliferation in the epidermis, facilitating skin barrier formation through lipid metabolism, and suppressing inflammatory responses. Furthermore, PPAR-α activity is reported to play a significant role in skin wound healing. Indeed, already known PPAR-α agonists such as clofibrate [Feingold et al., J. Invest. Dermatol., 110, pp368-375, 1998] and WY14643 [Feingold et al., J. Invest. Dermatol., 115, pp353-360, 2000; It has been confirmed that when [Korean Published Patent No. 10-2013-0120741] and others are applied to skin with a damaged skin barrier, the differentiation of keratinocytes is promoted and the recovery of the skin barrier is accelerated. In addition, endogenous ligands include α-linoleic acid, DHA, linoleic acid, arachidonic acid, LTB4, 12HETE, 15HETE, and prostaglandins. Furthermore, it has been reported that substances containing structurally diverse modified forms of lipid metabolites, such as hypolipidemic fibrate which acts as a lipid metabolism inhibitor, bind to PPAR-α. Among these receptors, PPAR is known to be a very important receptor for skin cell differentiation, barrier function recovery, and lipid biosynthesis. As a result of PPAR-α activation, the cornified envelope is formed, which promotes the expression of skin differentiation markers such as Filaggrin, Involucrin, and Loricrin; and as a result of PPAR-γ activation, the expression of Aquaporin 3, Involucrin, Loricrin, and Filaggrin is promoted, and as a result of PPAR-β/δ activati