KR-20260067710-A - COMPOSITION FOR PROMOTING HAIR GROWTH

Abstract

The present invention relates to a hair growth-promoting composition comprising: an extract of Opuntia ficus-indica; and amino clay nanoparticles, wherein the amino clay nanoparticles comprise at least one of Zn and Mg.

Inventors

• 문주영

Assignees

• 주식회사 퓨롬

Dates

Publication Date

20260513

Application Date

20241106

Claims (8)

1. Prickly Pear extract; and Amino clay nanoparticles; Includes, The above amino clay nanoparticles comprise at least one of Zn and Mg, Hair growth promoting composition.
2. In Article 1, The above hair growth-promoting composition promotes hair growth by irradiating with a red LED. Hair growth promoting composition.
3. In Article 1, Cell viability is reduced by the above-mentioned hair growth-promoting composition, Hair growth promoting composition.
4. In Article 1, Reactive Oxygen Species (ROS) are reduced by the above hair growth-promoting composition, Hair growth promoting composition.
5. In Article 1, Genotoxicity is reduced by the above hair growth-promoting composition, Hair growth promoting composition.
6. In Article 1, The antibacterial properties enhanced by the above-mentioned amino clay nanoparticles, Hair growth promoting composition.
7. In Article 1, The expression of Wnt3a and β-catenin is increased by the above hair growth-promoting composition, Hair growth promoting composition.
8. In Article 1, The above hair growth-promoting composition removes malodorous substances selected from the group consisting of trimethylamine, acetic acid, amino acids, and combinations thereof. Hair growth promoting composition.

Description

Composition for Promoting Hair Growth The present invention relates to a composition for promoting hair growth. Hair loss is one of the major concerns of modern people, caused by various factors such as stress, environmental pollution, and irregular lifestyles, and the number of people suffering from hair loss is continuously increasing. Accordingly, various products are being developed to prevent hair loss and promote hair growth. Conventional hair growth-promoting compositions primarily use chemical ingredients such as minoxidil as their main components; however, these chemical ingredients have the problem of potentially causing side effects such as scalp irritation and allergic reactions. Furthermore, existing hair growth-promoting compositions have limitations in that they lack antibacterial activity and cannot effectively inhibit the proliferation of microorganisms on the scalp. Recently, hair growth-promoting compositions using natural products have been developed, but they have issues such as insignificant effects or instability; in particular, the development of hair growth-promoting compositions that simultaneously possess antioxidant and antibacterial effects is currently lacking. Therefore, there is a need to develop a new hair growth-promoting composition that is based on natural ingredients, possesses excellent hair growth-promoting effects and antibacterial properties, has high stability, and is convenient to use. The technology forming the background of this invention, Korean Public Patent No. 10-2009-0002674, relates to a composition for preventing hair loss and promoting hair growth containing prickly pear extract. FIG. 1 is a schematic diagram of a microwave-assisted extraction process for Opuntia humifusa according to one embodiment of the present invention. Figure 2 is a graph showing the DPPH radical scavenging efficiency (%) of MA-OHE and L-ascorbic acid according to one experimental example of the present invention. Figure 3 is a graph showing the cytotoxicity according to MA-OHE treatment, red LED irradiation, and the combination therapy thereof according to one experimental example of the present invention. Figure 4 is a graph showing the generation of reactive oxygen species (ROS) in hair papilla cells (HFDPCs) under MA-OHE, red LED, or MA-OHE/red LED combined treatment conditions according to one experimental example of the present invention. Figure 5 shows the results of genotoxicity evaluation of dermal papilla cells using the Comet assay after treatment with MA-OHE treatment, red LED irradiation, and MA-OHE/red LED combination therapy for 24 hours according to one experimental example of the present invention, where (a) is a fluorescence image of dermal papilla cells after electrophoresis and (b) is a graph showing Tail DNA and Tail olive moment (%). Figure 6 shows the results of Wnt3a, β-catenin, and β-actin protein expression in dermal papilla cells according to MA-OHE, red LED, and combined MA-OHE/red LED treatment according to one experimental example of the present invention. Figure 7 is a graph showing the UV-Vis absorption spectrum at a concentration of 2.5 mg/mL according to one experimental example of the present invention. Figure 8 shows the results of the microdilution method of liquid medium according to one experimental example of the present invention, showing the antibacterial effect on initial E. coli (7.8 ± 0.021 × 10⁶ CFU/mL) and initial S. aureus (6.06 ± 0.003 × 10⁶ CFU/mL) under the condition of [10 mg/mL MgAC + 5 mg/mL ZnAC]. Figure 9 shows the results of the microdilution method of liquid medium according to one experimental example of the present invention, showing the antibacterial effect on initial E. coli (2.93 ± 0.89 × 10⁷ CFU/mL) and initial S. aureus (3.0 ± 2.0 × 10⁶ CFU/mL) under the condition [1.0 mg/mL MgAC + 0.5 mg/mL ZnAC]. Figure 10 is the result of a deodorization test report (commissioned in September 2021) under [10 mg/mL MgAC + 5 mg/mL ZnAC] conditions according to one experimental example of the present invention. Figure 11 is a photograph comparing (a) a commercial hair toner, a solution containing MgAC, ZnAC, and MA-OHE extracts, and (b) a commercial hair toner according to one experimental example of the present invention. Embodiments of the present invention are described below with reference to the attached drawings to enable those skilled in the art to easily implement the invention. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. Furthermore, in order to clearly explain the present invention in the drawings, parts unrelated to the explanation have been omitted, and similar parts throughout the specification are denoted by similar reference numerals. Throughout this specification, when a part is described as being "connected" to another part, this includes not only cases where they are "directly connected," but also cases where they are "electrically c