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KR-20260067738-A - Method for preparing recrystallized allantoin and cosmetic composition comprising recrystallized allantoin

KR20260067738AKR 20260067738 AKR20260067738 AKR 20260067738AKR-20260067738-A

Abstract

The present invention provides a method for producing recrystallized allantoin and a cosmetic composition comprising recrystallized allantoin. According to the method, recrystallized allantoin with a needle-like structure having a thin cross-sectional thickness can be produced, so the produced recrystallized allantoin can penetrate deeply into the skin, thereby enhancing skin permeability. Furthermore, the cosmetic composition exhibits excellent effects in improving skin wrinkles, skin elasticity, skin exfoliation, skin pores, and skin erythema, and causes minimal skin irritation.

Inventors

  • 정유진
  • 윤석균
  • 강승현

Assignees

  • 코스맥스 주식회사

Dates

Publication Date
20260513
Application Date
20241106

Claims (12)

  1. (1) A step of preparing a mixture by mixing allantoin and a crystal derivative; and (2) cooling the above mixture to obtain recrystallized allantoin A method for producing recrystallized allantoin, comprising
  2. A method for producing recrystallized allantoin according to claim 1, wherein the crystal derivative is one or more selected from the group consisting of polyquaternium-10, sodium hexametaphosphate, and didecyldimonium chloride.
  3. A method for producing recrystallized allantoin according to claim 1, wherein the mixing is performed at a temperature of 50 to 100°C.
  4. A method for producing recrystallized allantoin according to claim 1, wherein the cooling is performed at a temperature of 0 to 30°C.
  5. Recrystallized allantoin produced by the method of claim 1.
  6. Recrystallized allantoin according to claim 5, wherein the recrystallized allantoin has a needle-like structure.
  7. Recrystallized allantoin according to claim 5, wherein the recrystallized allantoin has a length of 200 to 900 μm.
  8. Recrystallized allantoin according to claim 5, wherein the recrystallized allantoin has a cross-sectional thickness of 10 to 400 μm.
  9. Cosmetic composition containing recrystallized allantoin.
  10. A cosmetic composition according to claim 9, wherein the recrystallized allantoin is the recrystallized allantoin defined by any one of claims 5 to 8.
  11. A cosmetic composition according to claim 9, wherein the cosmetic composition is for improving skin health.
  12. A cosmetic composition according to claim 11, wherein the improvement of skin health is improvement of skin wrinkles, improvement of skin elasticity, improvement of skin exfoliation, improvement of skin pores, or improvement of skin erythema.

Description

Method for preparing recrystallized allantoin and cosmetic composition comprising recrystallized allantoin The present invention relates to a method for producing recrystallized allantoin and a cosmetic composition containing recrystallized allantoin. Skin aging is a phenomenon caused by the influence of various factors, including lifestyle, environmental factors such as ultraviolet rays, genetics, and hormones. Aging leads to a decrease in skin elasticity due to the reduction of collagen and elastin, which in turn causes wrinkles to form. Furthermore, while the skin undergoes a turnover process in which it continuously produces new keratinocytes and sheds old ones, this turnover slows down due to aging. Consequently, dead skin cells accumulate, leading to a dull skin tone and rough texture. Recently, cosmetic methods that prevent skin aging by creating microscopic wounds on the skin to induce the production of collagen and elastin and increase the skin turnover cycle have been gaining popularity. In cosmetic procedures, microneedling and laser peeling fall into this category, while in cosmetics, anti-aging and exfoliation materials utilizing needle-shaped silica particles, known as microneedles or spicules, are included. Currently used microneedles utilize spicules or hydrolyzed sponges extracted from sponges, but they have the disadvantage of not aligning with the current cosmetic trend of seeking plant-derived materials. Furthermore, the silica component itself, which makes up the microneedles, has minimal skin efficacy, and there are safety issues as it does not decompose when applied to the skin, leading to persistent irritation. Consequently, there is a demand for new microneedles that are vegan and possess skin benefits through their ingredients. Allantoin is an ingredient used in cosmetics due to its excellent regenerative and soothing properties. While there is extensive literature on the skin efficacy of dissolved allantoin, no research has been conducted specifically targeting skin benefits by physically stimulating the skin with allantoin crystals. Figure 1 is an optical microscope image of an allantoin-impregnated spicule of Comparative Example 1. Figure 2 is an optical microscope image of the needle-shaped allantoin microneedle (4°C) of Example 1. Figure 3 is an optical microscope image of the needle-shaped allantoin microneedle (25°C) of Example 2. The following examples will be explained in more detail. However, these examples are intended to illustrate one or more specific examples, and the scope of the present invention is not limited to these examples. Comparative Example 1: Allantoin-impregnated spicules Allantoin-impregnated spicules were prepared by air-mixing a 10% (w/w) allantoin aqueous solution while spraying it onto a sponge spicule (Spicule 95, Neocam Korea). Example 1: Needle-shaped allantoin microneedles (4°C) 4 wt% of allantoin and 1 wt% of crystal derivative (Polyquaternium-10) were added while maintaining the temperature at 75°C, and then cooled to 4°C. Due to the temperature difference between the mixing stage and the cooling stage, allantoin precipitated as crystals, and the precipitated crystals were separated by filtration. Example 2: Needle-shaped allantoin microneedles (25℃) 4 wt% of allantoin and 1 wt% of crystal derivative (Polyquaternium-10) were added while maintaining the temperature at 75°C, and then cooled to 25°C. Due to the temperature difference between the mixing stage and the cooling stage, allantoin precipitated as crystals, and the precipitated crystals were separated by filtration. Experimental Example 1: Analysis of the structure and size of allantoin-impregnated spicules, needle-shaped allantoin microneedles (4°C), and needle-shaped allantoin microneedles (25°C) The structure and size of allantoin-impregnated spicules, needle-shaped allantoin microneedles (4°C), and needle-shaped allantoin microneedles (25°C) were analyzed through microscopic images. Figure 1 is an optical microscope image of an allantoin-impregnated spicule of Comparative Example 1. Figure 2 is an optical microscope image of the needle-shaped allantoin microneedle (4°C) of Example 1. Figure 3 is an optical microscope image of the needle-shaped allantoin microneedle (25°C) of Example 2. As a result, as shown in Figure 1, the allantoin-impregnated spicules were observed to have a length of 30 to 40 μm and a thin needle-like structure. Meanwhile, as shown in FIGS. 2 and 3, the allantoin crystals prepared in Example 1 or 2 had a crystal length of 80–100 μm when cooled at 25°C, but decreased to 30–40 μm when cooled at 4°C, exhibiting a shape more similar to a spicule. Additionally, the allantoin crystals showed a thick rectangular shape with a cross-sectional thickness of 20–30 μm when cooled at 25°C, but exhibited a much thinner needle-like structure with a cross-sectional thickness of 1–10 μm when cooled at 4°C. Experimental Example 2: Comparison of Skin Efficacy of Allantoin-Impregnated