KR-20260067743-A - COSTMETIC COMPOSITION FOR MAINTAING THE BALANCE OF MICROBIOME IN THE SKIN COMPRISING EXTRACT OF CASTANOPSIS SIEBOLDII AS ACTIVE INGREDIENT

Abstract

This application relates to a cosmetic composition for maintaining skin microbiome balance comprising an extract of Castanopsis sieboldii, which has the advantage of inhibiting harmful skin bacteria, maintaining or increasing beneficial skin bacteria, and having excellent antioxidant effects.

Inventors

• 한성수
• 김준
• 장성한
• 오대주
• 고보람
• 권미예
• 이윤지

Assignees

• 주식회사 로나스코스메틱
• 재단법인 제주테크노파크

Dates

Publication Date

20260513

Application Date

20241106

Claims (10)

1. A cosmetic composition for maintaining skin microbiome balance containing an extract of Castanopsis sieboldii as an active ingredient.
2. In claim 1 The above cosmetic composition is, A cosmetic composition characterized by inhibiting harmful skin bacteria.
3. In claim 2 The above harmful bacteria are, A cosmetic composition characterized by being one or more of Staphylococcus aureus , Pseudomonas aeruginosa , Corynebacterium diphtheriae , Streptococcus pyogenes, Acinetobacter junii , Cutibacterium acnes , and Stenotrophomonas maltophilia .
4. In claim 1 The above cosmetic composition is, A cosmetic composition characterized by maintaining or increasing beneficial skin bacteria.
5. In claim 4 The above beneficial bacteria are, A cosmetic composition characterized by being Staphylococcus epidermidis or Lactobacillus plantarum.
6. In claim 1 The above cosmetic composition is, A cosmetic composition characterized by having antioxidant efficacy.
7. In claim 1 The above extract is A cosmetic composition characterized by being extracted using an extraction solvent selected from the group consisting of water, distilled water, purified water, anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms, ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, methylene chloride, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, and hexane.
8. In claim 1 The extract of the above-mentioned Castanopsis sieboldii is, A cosmetic composition characterized by being an extract of the leaves or stems of Castanopsis sieboldii.
9. A quasi-drug composition for maintaining skin microbiome balance containing an extract of Castanopsis sieboldii as an active ingredient.
10. In claim 9 The above quasi-drug composition is, A quasi-drug composition characterized by inhibiting harmful skin bacteria or maintaining or increasing beneficial skin bacteria.

Description

Cosmetic composition for maintaining skin microbiome balance comprising Castanopsis sieboldii extract as an active ingredient The present application relates to a cosmetic composition for maintaining skin microbiome balance comprising an extract of Castanopsis sieboldii as an active ingredient. The term "microbiome" is a compound of "microbiota" and "genome." It refers to a community of microorganisms that inhabits or coexists in all environments—including humans, animals, plants, soil, oceans, lakes, rocks, and the atmosphere—and encompasses their entire genetic information; recently, the term has also come to refer to microbial communities in diverse environments. Furthermore, research is being conducted on various types of microbiomes, such as plant microbiomes, animal microbiomes, environmental microbiomes, human microbiomes, gut microbiomes, and skin microbiomes; among these, research on the human microbiome is the most extensive. Microorganisms present on the skin surface influence physiological processes such as human growth, nutrition, immunity, and resistance to pathogens, and play a role in blocking the invasion of external microorganisms, particularly pathogenic ones. The skin is an organ that plays a crucial role in maintaining internal homeostasis by protecting the body from external stimuli. Human skin is home to various microorganisms that obtain the substances necessary for their growth from sources such as sweat and sebum; while most of these thrive normally without causing harm, some are pathogenic. Some of these pathogenic microorganisms can penetrate deep into the skin through sweat glands, sebaceous glands, etc., and in such cases, cause various skin diseases. Most bacteria present on the skin are Gram-positive, and the growth of Gram-negative bacteria is relatively inhibited by these strains. For example, Staphylococcus is a major bacterium that causes skin diseases, producing invasive enzymes and disease-causing toxins. For example, Staphylococcus aureus , a representative bacterium belonging to the Staphylococcus family, is the most commonly isolated gram-positive coccus from clinical specimens and is a bacterium that frequently causes hospital-acquired infections. It is a purulent bacterium that can occur anywhere on the human body. Local infections include skin infections, folliculitis, impetigo, boils, and wound infections, while general diseases can include mucosal diseases, pneumonia, endocarditis, meningitis, sepsis, and food poisoning. When it infects the skin, it becomes a major causative agent of atopic dermatitis. Atopic dermatitis is a representative allergic skin disease characterized by severe itching and inflammatory skin conditions that chronically fluctuate between periods of remission and exacerbation. While Staphylococcus aureus is present in only 2–5% of healthy skin, it is known to form colonies in 95% of atopic patients. Conventionally, synthetic organic or inorganic antimicrobial agents have been used to inhibit the activity of these harmful microorganisms. However, existing synthetic organic antimicrobial agents have the disadvantage of being highly irritating to the eyes, skin, and sense of smell, and exhibiting weak antimicrobial activity against Gram-negative bacteria. Inorganic antimicrobial agents generally have weak antimicrobial efficacy; in particular, they show almost no antimicrobial activity against molds and suffer from a rapid decline in efficacy upon contact with moisture. Furthermore, for substances that come into daily contact with the skin, such as cosmetics, ingredients with such strong irritants are not suitable. To date, the discovery of materials related to enhancing skin functionality by directly regulating the skin microbiome has been insufficient. Therefore, there was a need to develop materials capable of improving skin functionality by directly regulating the skin microbiome. Figure 1 shows the inhibition zone for the harmful bacteria inhibition effect of Example 1. Figure 2 shows the inhibition zone for the harmful bacteria inhibition effect of Example 2. Figure 3 shows the ABTS radical scavenging ability of Example 1. Figure 4 shows the ABTS radical scavenging ability of Example 2. The present application will be described in more detail below. The following specific functional descriptions are merely illustrative to explain embodiments according to the concept of the present application, and embodiments according to the concept of the present application may be implemented in various forms and should not be interpreted as being limited to the embodiments described herein. Since embodiments according to the concept of the present application may be subject to various modifications and may take various forms, specific embodiments are to be described in detail in this specification. However, this is not intended to limit the embodiments according to the concept of the present application to specific disclosed forms, and it should be un