KR-20260067822-A - Cosmetic composition containing oregano(Origanum vulgare) extract as an effective ingredient and its manufacturing method

Abstract

The present invention relates to a cosmetic composition containing oregano extract as an active ingredient, and more specifically, to the whitening efficacy of an extract of the oregano part. A cosmetic composition containing oregano extract as an active ingredient according to the present invention has the advantage of enhancing the whitening effect by confirming the content of organonitron compounds and melanin biosynthesis inhibitory activity, and can be utilized as a cosmetic composition.

Inventors

• 강정욱
• 이인철
• 유단희
• 김정환

Assignees

• 서원대학교산학협력단

Dates

Publication Date

20260513

Application Date

20241106

Claims (3)

1. A cosmetic composition containing oregano extract as an active ingredient, characterized by containing oregano 70% ethanol extract as an active ingredient and having a whitening effect.
2. In paragraph 1, The above extract is, It contains organonitrile compounds and has melanin production inhibitory activity, A cosmetic composition containing oregano extract as an active ingredient, characterized by a concentration of 50 μg/ml.
3. In paragraph 2, The above extract is, A step of washing the oregano and then hot-air drying it at 60°C for 15 hours; A step of crushing the dried oregano above; A step of adding 10 parts by weight of 70% ethanol to 1 part by weight of the crushed oregano and stirring at room temperature for 24 hours; and The method includes a step of separating the supernatant and the precipitate through primary filtration using a nonwoven fabric after the above stirring step; A second step of adding 10 parts by weight of 70% ethanol based on 1 part by weight of the precipitate obtained from the above stirring step and the step of separating the supernatant and precipitate, and stirring and separating the supernatant and precipitate; and A third step of adding 10 parts by weight of 70% ethanol based on 1 part by weight of the precipitate obtained from the second step above, and stirring and separating the supernatant and the precipitate; further comprising A step of secondary filtration of the supernatant obtained from 70% ethanol extraction using filter paper and a vacuum pump; A step of concentrating the supernatant of the second filtered liquid using a rotary evaporator under reduced pressure; and A method for preparing a cosmetic composition containing oregano extract as an active ingredient, characterized by further including the step of freeze-drying the concentrate concentrated under reduced pressure as described above.

Description

Cosmetic composition containing oregano (Origanum vulgare) extract as an effective ingredient and its manufacturing method The present invention relates to a cosmetic composition containing oregano extract as an active ingredient, and more specifically, to the whitening efficacy of oregano extract. In modern society, rapid advancements in science and technology have led to increased life expectancy and improved living standards, resulting in a growing interest in beauty alongside health. In particular, due to environmental pollution, ozone depletion, and various chemical and synthetic substances, there is increasing interest in superior natural materials that cause fewer side effects on the skin. The epidermis is located at the outermost layer of the skin and possesses a barrier function to protect against the influx of various external factors, such as ultraviolet rays, viruses, and harmful substances. It is known to primarily contain keratinocytes, Langerhans immune cells, and melanocytes. When the skin is subjected to continuous stimuli—such as external factors like ultraviolet rays and environmental pollution, or internal factors like aging and mental stress—reactive oxygen species (ROS) are generated, leading to oxidative stress. This oxidative stress causes the oxidation of proteins or DNA, lipid peroxidation, and the destruction of skin antioxidants. Consequently, the skin barrier function fails to operate smoothly, resulting in harmful effects such as chronic inflammatory diseases, increased melanin production, and pigmentation caused by premature aging. α-melanocyte-stimulating hormone (α-MSH), secreted when skin is exposed to ultraviolet rays, activates various intracellular signals and factors and induces the expression of tyrosinase by increasing the expression of microphthalmia-associated transcription factor, a key transcription regulator in the melanin synthesis process. Tyrosinase, a key enzyme that produces melanin polymers, converts L-tyrosine into L-dihydroxyphenylalanine (L-DOPA), L-DOPA into DOPA quinone, and DOPA quinone into dopachrome through auto-oxidation and enzymatic reactions to produce melanin, a dark brown copolymer. However, since excessive melanin production in the skin can cause pigmentation, melasma, freckles, and skin cancer, research is continuously being conducted on the possibility of inducing a whitening effect by inhibiting tyrosinase activity to suppress melanin synthesis. Meanwhile, oregano (Origanum vulgare) is a herbaceous plant with a unique aroma and taste, belonging to the family Lamiaceae, and grows in North Africa, Europe, and Asia. Although it is known to be mostly cultivated for ornamental purposes or widely used as a raw material for spices, it is also used in traditional medicine for conditions such as rheumatoid arthritis and respiratory diseases. Essential oils extracted from oregano possess antioxidant, anti-tumor, and antibacterial activities, and it is reported that oregano contains linalool, tymol, carvacrol, pinterpinene, and rosmarinic acid, giving it powerful antioxidant capabilities. However, research results regarding solvent-extracted whole oregano plants, such as those for skin whitening, are currently insufficient. As such, since the verification of the biological activity of oregano extract is currently insufficient, this study aimed to verify its whitening efficacy in order to utilize oregano extract as a natural cosmetic ingredient. FIG. 1 is a graph briefly illustrating the results of an analysis of indicator substances of oregano extract in a cosmetic composition containing oregano extract as an active ingredient according to an embodiment of the present invention. FIG. 2 is a graph briefly illustrating the measurement results of melanin synthesis inhibition of a cosmetic composition containing oregano extract as an active ingredient according to an embodiment of the present invention. Hereinafter, preferred embodiments are described in detail with reference to the attached drawings so that those skilled in the art can easily practice the present invention. However, in describing the preferred embodiments of the present invention in detail, if it is determined that a detailed description of related known functions or configurations may unnecessarily obscure the essence of the present invention, such detailed description is omitted. Additionally, the same reference numerals are used throughout the drawings for parts having similar functions and operations. Additionally, throughout the specification, when a part is described as being 'connected' to another part, this includes not only cases where they are 'directly connected,' but also cases where they are 'indirectly connected' with other elements in between. Furthermore, the description of a component as 'including' means that, unless specifically stated otherwise, it does not exclude other components but may include additional components. FIG. 1 is a graph briefly illustrating the res