KR-20260067975-A - Radical and photothermal reaction inducing composite for polymer degradation

KR20260067975AKR 20260067975 AKR20260067975 AKR 20260067975AKR-20260067975-A

Abstract

The present invention relates to a composite that promotes polymer degradation by inducing radical generation and photothermal reactions. The composite comprises a core having a core-shell structure that generates radicals in response to ultrasound, and a photothermal conversion carrier shell that induces heat generation upon near-infrared irradiation. The composite is applied to polymer structures implanted in the body to precisely induce polymer chain cleavage and degradation in response to external stimuli. This accelerates the rate of biodegradation and ensures safety within the body.

Inventors

김상우
김다빈
전세라

Assignees

연세대학교 산학협력단

Dates

Publication Date: 20260513
Application Date: 20250911
Priority Date: 20241106

Claims (10)

As a radical and photothermal reaction-induced polymer degradation composite having a core-shell structure, A core comprising a radical-generating material that cleaves polymer chains; and A shell comprising a photothermal conversion carrier material that promotes polymer chain cleavage through heat generation by near-infrared irradiation, Radical and photothermal reaction-induced polymer decomposition complex.
In Article 1, The above radical-generating substance generates radicals by the application of ultrasound, Radical and photothermal reaction-induced polymer decomposition complex.
In Article 2, The above radical-generating substance comprises one or more of AIPH (2,2'-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride), 4,4'-azobis(4-cyanopentanoic acid), BaTiO3 , curcumin, methylene blue, and indocyanine green, Radical and photothermal reaction-induced polymer decomposition complex.
In Article 1, The above photothermal conversion carrier material comprises a metal-organic framework (MOF) material, MXene, polydopamine, or gold nanocages, Radical and photothermal reaction-induced polymer decomposition complex.
In Article 4, The above MOF material comprises MIL-100(Fe) or MIL-101(Fe), Radical and photothermal reaction-induced polymer decomposition complex.
In Article 1, The above photothermal conversion carrier material generates heat upon application of near-infrared (NIR), Radical and photothermal reaction-induced polymer decomposition complex.
In Article 6, When the photothermal conversion carrier material generates heat due to the above near-infrared rays, the wavelength and intensity of the light are adjusted so as not to affect the body, thereby controlling the heat generation temperature to be between approximately 36°C and 40°C. Radical and photothermal reaction-induced polymer decomposition complex.
In Article 7, The wavelength of the light is 700 to 850 nm, Radical and photothermal reaction-induced polymer decomposition complex.
In Article 7, The intensity of the light is 0.5 to 2.0 W/ cm² . Radical and photothermal reaction-induced polymer decomposition complex.
A polymer-based implantable device comprising a radical and photothermal reaction-inducing polymer decomposition complex according to any one of claims 1 to 9, The above-mentioned polymer-based implantable device performs its function within the body for a certain period and is capable of degrading the polymer by the application of near-infrared rays and ultrasound. Polymer-based implantable device.

Description

Radical and photothermal reaction inducing composite for polymer degradation The present invention relates to a composite for inducing the degradation of a polymer material, and more specifically, to a core-shell structured composite capable of non-invasively inducing the degradation of an implantable polymer-based device by utilizing a photothermal reaction and radical generation. In particular, the present invention relates to a technology capable of effectively cleaving polymer chains and promoting degradation through photothermal effects caused by near-infrared (NIR) irradiation and radical generation caused by ultrasonic stimulation, and relates to a biocompatible composite that can be usefully applied to control and accelerate the degradation of medical polymer materials that biodegrade and naturally disappear after performing a function in the body for a specific period. With the advancement of medical technology, polymer-based medical implants inserted into the body for purposes such as tissue regeneration, nerve reconstruction, and fracture treatment are widely used. These implantable medical devices must naturally decompose within the body after performing the function of supporting or protecting tissues for a certain period, so that they can be safely excreted or absorbed without the need for a second surgery. Accordingly, polymeric biodegradable materials are being actively developed; however, there are limitations in effectively controlling or accelerating the rate of degradation in the actual in vivo environment. Previously, methods involving the ex vivo addition of enzymes were used to promote polymer degradation; however, it is difficult to deliver external enzymes or ensure they act precisely on the reaction site within the in vivo environment. Accordingly, methods utilizing high-intensity ultrasound to physically fragment polymer implants or increase their surface area to accelerate hydrolysis have recently been proposed; however, these methods also face technical limitations due to the need for localized and direct stimulation and the difficulty in controlling degradation. Therefore, there is an urgent need for the development of a technology capable of precisely inducing and controlling the degradation of polymer materials inserted into the body in a non-invasive manner—specifically, a new mechanism that can cleave polymer chains by generating radicals internally or inducing localized heat in response to external stimuli. FIG. 1 illustrates a schematic design of a radical and photothermal reaction-induced polymer decomposition composite according to one embodiment of the present invention. Figure 2 illustrates the verification of radical generation and photothermal reaction effects of a polymer decomposition promoting material. Figure 3 shows a graph of light absorption by wavelength for MIL-100 (Fe). Various embodiments are now described with reference to the drawings, and throughout the drawings, similar reference numerals are used to denote similar elements. For illustrative purposes, various descriptions are provided in this specification to facilitate an understanding of the invention. However, it is evident that these embodiments can be practiced without such specific descriptions. In other examples, known structures and devices are presented in the form of block diagrams to facilitate the description of the embodiments. Hereinafter, embodiments of the present invention will be described in detail with reference to the attached drawings. As the present invention is susceptible to various modifications and may take various forms, specific embodiments are illustrated in the drawings and described in detail in the text. However, this is not intended to limit the present invention to the specific disclosed forms, and it should be understood that the invention includes all modifications, equivalents, and substitutions that fall within the spirit and scope of the invention. Similar reference numerals have been used for similar components in the description of each drawing. The terms used in this application are used merely to describe specific embodiments and are not intended to limit the invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In this application, terms such as "comprising" or "having" are intended to indicate the presence of the features, steps, actions, components, parts, or combinations thereof described in the specification, and should be understood as not precluding the existence or addition of one or more other features, steps, actions, components, parts, or combinations thereof. The present invention relates to a composite that promotes polymer decomposition by inducing radical generation and photothermal reactions, comprising a core having a core-shell structure that generates radicals in response to ultrasound, and a photothermal conversion carrier shell that induces heat generation upon near-infrared irr