RU-2023106426-A - METHODS AND APPLICATIONS OF MICROBIOME COMPOSITIONS

Inventors

• ГОВИНДАН, Джоти Амаранат
• ДЖАЯМАНИ, Элампарити
• ЧАТТЕР, Прити Х.
• ЧАТТЕР, Мукеш

Assignees

• МАРВЕЛБИОМ, ИНК.

Dates

Publication Date

20260505

Application Date

20210910

Priority Date

20200911

Claims (20)

1. 1. A method comprising:
2. determining the level of one or more metabolites in a sample obtained from a subject, wherein the subject has received:
3. (i) a composition comprising one or more strains of microorganisms;
4. (ii) a composition comprising one or more lipopolysaccharides; or
5. (iii) a combination of them.
6. 2. The method of claim 1, wherein the subject is a mammal.
7. 3. The method according to claim 1 or 2, wherein the subject is a human being.
8. 4. The method according to any one of claims 1-3, wherein one or more strains of microorganisms are representatives of the mammalian microbiome.
9. 5. The method according to any one of claims 1-4, wherein one or more strains of microorganisms are representatives of the human microbiome.
10. 6. The method according to any one of claims 1-5, wherein one or more strains of microorganisms are representatives of the microbiome of the subject.
11. 7. The method according to any one of claims 1-6, wherein one or more strains of microorganisms are selected from TABLE 5.
12. 8. The method according to any one of claims 1 to 7, wherein one or more strains of microorganisms are Gluconacetobacter hansenii, Terrisporobacter glycolicus, Coprococcus sp., Lactobacillus plantarum, Clostridium butyricum, Paenibacillus sp., Veillonella sp., Bifidobacterium sp., Bacillus subtilis, Acidaminococcus sp. or a combination thereof.
13. 9. The method according to any one of claims 1 to 8, wherein the composition comprises two or more strains of microorganisms.
14. 10. The method according to any one of claims 1 to 9, wherein the composition comprises five or more strains of microorganisms.
15. 11. The method according to any one of claims 1-10, wherein the composition comprises ten or more strains of microorganisms.
16. 12. The method according to any one of claims 1-11, wherein the composition comprises Gluconacetobacter hansenii, Terrisporobacter glycolicus, Coprococcus sp., Lactobacillus plantarum, Clostridium butyricum, Paenibacillus sp., Veillonella sp., Bifidobacterium sp., Bacillus subtilis and Acidaminococcus sp.
17. 13. The method according to any one of claims 1 to 12, wherein one or more lipopolysaccharides are obtained from E. coli.
18. 14. The method according to any one of claims 1 to 13, wherein one or more lipopolysaccharides are obtained from E. coli 0111.B4.
19. 15. The method according to any one of claims 1-14, wherein one or more metabolites are selected from TABLE 1, TABLE 2, TABLE 3, TABLE 4 or a combination thereof.
20. 16. The method according to any one of claims 1-15, wherein at least one of the one or more metabolites is associated with a disease, disorder or condition.