RU-2023128348-A - METHODS OF TREATMENT OF INFLAMMATION

Inventors

• Стейнер, Митчелл С.
• БАРНЕТ, Кестер Гари

Assignees

• ВЕРУ ИНК.

Dates

Publication Date

20260508

Application Date

20210804

Priority Date

20210405

Claims (20)

1. 1. A method of treating inflammation in a subject in need thereof by administering to the subject a composition containing a therapeutically effective amount of a compound of formula (I):
2. wherein A is phenyl, indolyl or indazolyl optionally substituted with at least one of the following: (C 1 -C 4 ) alkyl, halo(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) haloalkyl, (C 1 -C 4 ) alkylamino, amino(C 1 -C 4 ) alkyl, F, Cl, Br, I, CN, -CH 2 CN, NH 2 , hydroxyl, OC(O)CF 3 , -OCH 2 Ph, -NHCO-(C 1 -C 4 ) alkyl, COOH, -C(O)Ph, C(O)O-(C 1 -C 4 ) alkyl, C(O)H, -C(O)NH 2 or NO 2 ;
3. B is imidazole or benzimidazole optionally substituted with at least one of the following: (C 1 -C 4 ) alkyl, halo(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) alkyl, O-halo(C 1 -C 4 ) alkyl, F, Cl, Br, I, CN, -CH 2 CN, hydroxyl or NO 2 ;
4. R 1 , R 2 and R 3 independently represent at least one of the following: hydrogen, (C 1 -C 4 ) alkyl, halo(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) haloalkyl, (C 1 -C 4 ) alkylamino, amino(C 1 -C 4 ) alkyl, F, Cl, Br, I, CN, -CH 2 CN, NH2, hydroxyl, OC(O)CF 3 , -OCH 2 Ph, -NHCO-(C 1 -C 4 ) alkyl, COOH, -C(O)Ph, C(O)O-(C 1 -C 4 ) alkyl, C(O)H, -C(O)NH 2 or NO 2 ;
5. X represents a bond or NH;
6. Y represents -C=O; and
7. m is 1-3,
8. or a pharmaceutically acceptable salt, hydrate, polymorph or isomer thereof.
9. 2. The method of treating inflammation according to claim 1, wherein A is phenyl or indolyl optionally substituted with at least one of the following: (C 1 -C 4 ) alkyl, halo(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) haloalkyl, (C 1 -C 4 ) alkylamino, amino(C 1 -C 4 ) alkyl, F, Cl, Br, I, CN, -CH 2 CN, NH 2 , hydroxyl, OC(O)CF 3 , -OCH 2 Ph, -NHCO-(C 1 -C 4 ) alkyl, COOH, -C(O)Ph, C(O)O-(C 1 -C 4 ) alkyl, C(O)H, -C(O)NH 2 or NO 2 ;
10. B is imidazole optionally substituted with at least one (C 1 -C 4 ) alkyl;
11. R 1 , R 2 and R 3 independently represent at least one of the following: hydrogen, (C 1 -C 4 ) alkyl, halo(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) haloalkyl, (C 1 -C 4 ) alkylamino, amino(C 1 -C 4 ) alkyl, F, Cl, Br, I, CN, -CH 2 CN, NH2, hydroxyl, OC(O)CF 3 , -OCH 2 Ph, -NHCO-(C 1 -C 4 ) alkyl, COOH, -C(O)Ph, C(O)O-(C 1 -C 4 ) alkyl, C(O)H, -C(O)NH 2 or NO 2 ;
12. X represents a bond or NH;
13. Y represents -C=O; and
14. m is 1-3,
15. or a pharmaceutically acceptable salt, hydrate, polymorph or isomer thereof.
16. 3. The method of treating inflammation according to claim 1, wherein A is phenyl optionally substituted with at least one of the following: (C 1 -C 4 ) alkyl, halo(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) haloalkyl, (C 1 -C 4 ) alkylamino, amino(C 1 -C 4 ) alkyl, F, Cl, Br, I, CN, -CH 2 CN, NH 2 , hydroxyl, OC(O)CF 3 , -OCH 2 Ph, -NHCO-(C 1 -C 4 ) alkyl, COOH, -C(O)Ph, C(O)O-(C 1 -C 4 ) alkyl, C(O)H, -C(O)NH 2 or NO 2 ;
17. B is imidazole optionally substituted with at least one (C 1 -C 4 ) alkyl;
18. R 1 , R 2 and R 3 independently represent at least one of the following: hydrogen, (C 1 -C 4 ) alkyl, halo(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) alkyl, O-(C 1 -C 4 ) haloalkyl, (C 1 -C 4 ) alkylamino, amino(C 1 -C 4 ) alkyl, F, Cl, Br, I, CN, -CH 2 CN, NH 2 , hydroxyl, OC(O)CF 3 , -OCH 2 Ph, -NHCO-(C 1 -C 4 ) alkyl, COOH, -C(O)Ph, C(O)O-(C 1 -C 4 ) alkyl, C(O)H, -C(O)NH 2 or NO 2 ;
19. X represents a bond or NH;
20. Y represents -C=O; and