RU-2024132736-A - TRI-SPECIFIC BCMA-BINDING MOLECULES AND THEIR ROUTES OF USE
RU2024132736ARU 2024132736 ARU2024132736 ARU 2024132736ARU-2024132736-A
Inventors
- ГРАНДА, Брайан
- Бланкеншип, Джон
- Эйбьюджоуб, Аида
- Флеминг, Тони
- Лу, Хайхой
- ХУАН, Лу
- Хонг, Конни
- Хольмберг, Брайан
Assignees
- НОВАРТИС АГ
Dates
- Publication Date
- 20260504
- Application Date
- 20241101
- Priority Date
- 20190521
Claims (4)
- 1. A polyspecific binding molecule (PSBM) comprising:
- (a) antigen-binding module 1 (ABM1) that specifically binds to human BCMA and comprises the CDR-L1, CDR-L2, and CDR-L3 sequences shown in Table 11A-1, Table 11B-1, Table 11C-1, Table 11D-1, Table 11E-1, Table 11F-1, Table 11G-1, Table 11H-1, Table 11I-1, Table 11J-1, Table 11K-1(a), Table 11K-1(b), Table 11L-1, Table 11M-1, Table 11N-1(a), or Table 11N-1(b), and the corresponding CDR-H1, CDR-H2, and CDR-H3 sequences shown in Table 11A-2, Table 11B-2, Table 11C-2, Table 11D-2, Table 11E-2, Table 11F-2, Table 11G-2, Table 11H-2, Table 11I-2, Table 11J-2, Table 11K-2, Table 11K-2, Table 11L-2, Table 11M-2, Table 11N-2, or Table 11N-2, respectively;
- (b) antigen-binding module 2 (ABM2), which specifically binds to a component of the human T-cell receptor complex (TCR); and
- (c) antigen-binding module 3 (ABM3), which specifically binds to human CD2 or human tumor-associated antigen (TAA).