RU-2024132889-A - T-CELL RECEPTORS RECOGNIZING THE R175H OR Y220C MUTATION IN P53

Inventors

• Денигер, Дрю С.
• Малекзадех, Париза
• Розенберг, Стивен А.
• Пасетто, Анна

Assignees

• ДЗЕ ЮНАЙТЕД СТЕЙТС OФ АМЕРИКА, ЭЗ РЕПРЕЗЕНТЕД БАЙ ДЗЕ СЕКРЕТАРИ, ДЕПАРТМЕНТ ОФ ХЕЛС ЭНД ХЬЮМАН СЁРВИСЕЗ

Dates

Publication Date

20260504

Application Date

20241101

Priority Date

20190627

Claims (20)

1. 1. An isolated or purified T cell receptor (TCR) having antigen specificity for the amino acid sequence of human p53 R175H , wherein said TCR comprises the following amino acid sequences:
2. (1) all of SEQ ID NO: 3-8;
3. (2) all of SEQ ID NO: 14-19;
4. (3) all of SEQ ID NO: 25-30;
5. (4) all of SEQ ID NO: 36-41;
6. (5) all of SEQ ID NO: 47-52;
7. (6) all of SEQ ID NO: 58-63;
8. (7) all of SEQ ID NO: 69-74; or
9. (8) all of SEQ ID NO: 131-136.
10. 2. The TCR of claim 1, wherein said TCR comprises the following amino acid sequences:
11. (1) both SEQ ID NO: 9 and 10;
12. (2) both SEQ ID NO: 20 and 21;
13. (3) both SEQ ID NO: 31 and 32;
14. (4) both SEQ ID NO: 42 and 43;
15. (5) both SEQ ID NO: 53 and 54;
16. (6) both SEQ ID NO: 64 and 65;
17. (7) both SEQ ID NO: 75 and 76;
18. (8) both SEQ ID NO: 137 and 138;
19. (9) both SEQ ID NO: 142 and 143;
20. (10) both SEQ ID NO: 144 and 145;