RU-2025133512-A - PHARMACEUTICAL COMBINATIONS AND COMPOSITIONS BASED THEREON, INCLUDING ANTIBACTERIAL AGENTS

Inventors

• ГУПТЕ, Вайшали Викас
• ГОГТАЙ, Джайдип Ашок
• САВАНТ, Сандеш Вишванат

Assignees

• СИПЛА ЛИМИТЕД

Dates

Publication Date

20260507

Application Date

20240502

Priority Date

20230502

Claims (20)

1. 1. A pharmaceutical composition comprising (a) an effective amount of meropenem, (b) an effective amount of avibactam, and (c) an effective amount of EDTA.
2. 2. The pharmaceutical composition of claim 1, wherein meropenem is present in an amount of 1 gram to 10 grams, avibactam is present in an amount of 1 gram to 5 grams, and EDTA is present in an amount of 100 mg to 300 mg.
3. 3. The pharmaceutical composition according to claim 2, wherein said combination comprises meropenem, avibactam and EDTA in any of the following quantities:
4. (i) about 3 grams of meropenem, about 1.5 grams of avibactam, and about 111 mg of EDTA; or
5. (ii) about 3 grams of meropenem, about 1.5 grams of avibactam, and about 222 mg of EDTA; or
6. (iii) about 3 grams of meropenem, about 3 grams of avibactam, and about 111 mg of EDTA; or
7. (iv) about 3 grams of meropenem, about 3 grams of avibactam, and about 222 mg of EDTA; or
8. (v) about 6 grams of meropenem, about 1.5 grams of avibactam, and about 111 mg of EDTA; or
9. (vi) about 6 grams of meropenem, about 3 grams of avibactam and about 222 mg of EDTA.
10. 4. A pharmaceutical composition comprising: (a) meropenem, (b) avibactam and (c) EDTA together with one or more pharmaceutically acceptable carriers or excipients or the like.
11. 5. A method of treating a bacterial infection in a subject, said method comprising administering to said subject an effective amount of (a) meropenem, (b) avibactam, and (c) EDTA.
12. 6. The method of claim 5, wherein said methods comprise administering to said subject a daily dose of (a) 1 gram to 10 grams of meropenem, (b) 1 gram to 5 grams of avibactam, and (c) 100 mg to 300 mg of EDTA.
13. 7. The method of claim 6, wherein said method comprises administering to said subject a daily dose of: (a) meropenem, (b) avibactam, and (c) EDTA in any of the following amounts:
14. (i) about 3 grams of meropenem, about 1.5 grams of avibactam, and about 111 mg of EDTA; or
15. (ii) about 3 grams of meropenem, about 1.5 grams of avibactam, and about 222 mg of EDTA; or
16. (iii) about 3 grams of meropenem, about 3 grams of avibactam, and about 111 mg of EDTA; or
17. (iv) about 3 grams of meropenem, about 3 grams of avibactam, and about 222 mg of EDTA; or
18. (v) about 6 grams of meropenem; about 1.5 grams of avibactam; and about 111 mg of EDTA; or
19. (vi) about 6 grams of meropenem, about 3 grams of avibactam and about 222 mg of EDTA.
20. 8. A method for treating a bacterial infection in pediatric patients, said method comprising administering to said subject a daily dose of (a) meropenem from about 10 mg/kg to about 40 mg/kg, (b) avibactam from about 10 mg/kg to about 12.5 mg/kg, and (c) EDTA from about 1.85 mg/kg to about 3.7 mg/kg.