RU-2026108387-A - A mixture of OGM and the transitional microorganism BIFIDOBACTERIUM LONGUM

Inventors

• КВОН ЧОН, Чон Квет Чхве
• КАВЕН, Жан-Батист
• БУЛАНЖ, Клэр Лоранс Люси Мари
• ЧАРЛО, Элеонора
• ДЮБУА, Стефан
• НОТИ, Марио

Assignees

• СОСЬЕТЕ ДЕ ПРОДЮИ НЕСТЛЕ С.А.

Dates

Publication Date

20260505

Application Date

20230927

Claims (20)

1. 1. A composition comprising a transitional microorganism Bifidobacterium longum and a mixture of human breast milk oligosaccharides (HMOs) consisting of 2'-fucosyllactose (2'-FL), difucosyllactose (DFL), lacto-N-tetraose (LNT), 6'-sialyllactose (6SL) and 3'-sialyllactose (3SL), and optionally 3-fucosyllactose (3-FL) and/or lacto-N-neotetraose (LNnT).
2. 2. The composition according to claim 1, wherein the transitional microorganism Bifidobacterium longum:
3. (i) is capable of metabolizing OGM;
4. (ii) preferentially uses 3-FL over 2'-FL;
5. (iii) is capable of metabolizing a glycan substrate selected from the group specified in any of Tables 1-3; and/or
6. (iv) encodes one or more carbohydrate-active enzymes (CAZymes) selected from the group specified in Table 1, wherein preferably the transitional microorganism Bifidobacterium longum further encodes one or more CAZymes selected from Tables 2 and 3.
7. 3. The composition according to claim 1 or 2, wherein the transitional microorganism Bifidobacterium longum has an average nucleotide identity (ANI) of at least 98% with at least one strain of Bifidobacterium longum selected from the group consisting of CNCM I-5683, CNCM I-5684, CNCM I-5685, CNCM I-5686, CNCM I-5687, CMCC-P0001 (ATCC BAA-2753) and any combination thereof.
8. 4. The composition according to any of the preceding claims, further comprising Bifidobacterium longum subspecies infantis and/or Bifidobacterium lactis.
9. 5. The composition according to paragraph 4, in which:
10. (i) Bifidobacterium longum subspecies infantis is Bifidobacterium longum subspecies infantis LMG 11588 or has an average nucleotide identity (ANI) of at least 99.9% with Bifidobacterium longum subspecies infantis LMG 11588; and
11. (ii) Bifidobacterium lactis is Bifidobacterium lactis CNCM 1-3446 or has an average nucleotide identity (ANI) of at least 99.9% ANI with Bifidobacterium lactis CNCM 1-3446.
12. 6. The composition according to any one of the preceding claims, wherein the mixture of OGM consists of 2'-FL, DFL, LNT, 6SL and 3SL.
13. 7. The composition according to any one of claims 1-5, wherein the mixture of OGM consists of 2'-FL, DFL, LNT, 6SL, 3SL and 3-FL.
14. 8. The composition according to any one of claims 1-5, wherein the mixture of OGM consists of 2’-FL, DFL, LNT, 6SL, 3SL and LNnT.
15. 9. The composition according to any one of claims 1-5, wherein the mixture of OGM consists of 2’-FL, DFL, LNT, 6SL, 3SL, 3-FL and LNnT.
16. 10. A composition according to any one of the preceding claims, which is a nutritional composition selected from an infant formula, a starter infant formula, a follow-on infant formula or a follow-on formula, an infant food, a cereal-based infant formula, an infant formula for children aged 1 to 3 years, a fortifier, such as a human breast milk fortifier, or a supplement.
17. 11. The composition of any one of claims 1-10 for use in the prevention, reduction of risk and/or treatment of infection in a subject.
18. 12. The composition of any one of claims 1-10 for use in promoting long-term immune system benefit in a subject.
19. 13. The composition for use according to claim 12, wherein promoting long-term benefit to the immune system in a subject comprises:
20. i. promoting long-term respiratory health;