RU-2026112926-A - PREPARATION OF PENTACYCLIC IMIDAZOLE DERIVATIVES WITH BRIDGED BOND AS MODULATORS OF TNF ACTIVITY, INTERMEDIATE COMPOUNDS AND THEIR PREPARATION

Inventors

• БАРТ, Маттье
• БЕЙЛОН, Кристоф
• ГРЕСЬЕ, Элен
• СЕРФОНТЕН, Патрик
• ЖЕРАР, Жюльен
• ПЕТИ, Сильвен

Assignees

• САНОФИ
• ЮСБ БИОФАРМА СРЛ

Dates

Publication Date

20260505

Application Date

20240927

Priority Date

20230929

Claims (20)

1. 1. Method for obtaining intermediate compound 6:
2. intermediate compound 6,
3. wherein the method includes
4. a) carrying out the reaction of intermediate compound B:
5. intermediate compound B,
6. where R is a protecting group for the amino group,
7. with the reagent to obtain intermediate compound C:
8. intermediate compound C,
9. where R is a protecting group for the amino group,
10. And
11. b) reacting intermediate C with intermediate 5:
12. intermediate compound 5,
13. in the presence of a base and a palladium catalyst to yield intermediate compound 6.
14. 2. The method according to claim 1, wherein the reagent in step a) comprises bis(pinacolato)diboron.
15. 3. The method according to claim 1 or 2, wherein step a) comprises contacting the intermediate compound B with a palladium catalyst.
16. 4. The method according to claim 3, wherein the palladium catalyst is XPhos-PdG2.
17. 5. The method according to any one of claims 1 to 4, wherein the palladium catalyst used in step b) is XPhos-PdG2.
18. 6. Method for obtaining intermediate compound 4:
19. intermediate compound 4,
20. wherein the method includes