RU-2861278-C1 - METHOD FOR LOCAL TREATMENT OF APHTHOUS STOMATITIS IN CHILDREN

Abstract

FIELD: medicine; clinical dentistry. SUBSTANCE: invention can be used in the treatment of aphthous stomatitis in children. Lysobact lozenges are used, 1 tablet 3 times a day for 7 days. 30 minutes after dissolving, Phagodent gel is applied topically 3 times a day for 7 days. EFFECT: enhancement of the antibacterial effect, reduction in the healing time of affected areas of the oral mucosa, increase in the remission period, normalisation of the microflora and immunological parameters in the oral cavity. 1 cl, 4 dwg, 4 tbl, 2 ex

Inventors

• Akmalova Giuzel Maratovna
• Gimranova Irina Anatolevna
• Mannapova Guzel Rinatovna

Dates

Publication Date

20260504

Application Date

20251027

Claims (1)

1. A method for the local treatment of aphthous stomatitis in children, including the application of a drug containing bacteriophages to the oral mucosa (OM), characterized in that Lizobact lozenges are first used, 1 tablet 3 times a day, 30 minutes after dissolution, as a drug containing bacteriophages, Fagodent gel is applied to the affected areas of the OM by application 3 times a day, and the course of treatment with drugs is 7 days.

Description

The invention relates to medicine, namely to clinical dentistry, and can be used in the treatment of aphthous stomatitis in children. Aphthous stomatitis (AS) is a disease of the oral mucosa characterized by the appearance of painful aphthae with frequent and protracted relapses. The disease affects people of any age and gender [Kosyuga S.Yu., Klenina V.Yu. Modern aspects of the etiopathogenesis of recurrent aphthous stomatitis. Modern problems of science and education. 2014; 6; 1112-1117]. Exacerbations of aphthous stomatitis are seasonal, with peak episodes occurring in the fall and spring. The interval between exacerbations can range from several months to several years and depends on a variety of factors. Currently, this disease is very common among the population. According to various sources, this type of stomatitis affects 2 to 10% of the population across different age groups [S. Akintoye, M. Greenberg. Recurrent aphthous stomatitis. Dental Clinics of North America journal. 2014; 58(2): 281-297]. According to the classification proposed by I.M. Rabinovich (1998), four forms of chronic recurrent aphthous stomatitis are distinguished: fibrinous; necrotic; glandular; deforming. The most common localization of aphthae is the mucous membrane of the cheeks, lips, transitional fold, and dorsal surface of the tongue [Rabinovich I.M., Banchenko, G.V., Rabinovich, O.F., Bezrukova, I.V. Use of Tantum Verde in the treatment of diseases of the oral mucosa / I.M. Rabinovich, G.V. Banchenko, O.F. Rabinovich, I.V. Bezrukova // Stomatology, 1997. No. 2. P. 76.3]. Treatment of aphthous stomatitis in children is currently a pressing issue in dentistry due to the lack of specific therapy, frequent and prolonged relapses, and changes in the body's immune status. With a decline in general and, especially, local immunity in the oral cavity, alterations in the microbiota occur (opportunistic microorganisms transform into pathogenic microorganisms), increasing microbial aggressiveness and antibiotic resistance. Possessing a wide range of adaptive mechanisms, opportunistic gram-positive and gram-negative bacteria can produce certain pathogenic factors, the potential for action of which increases significantly when they associate, which, in turn, leads to a prolonged course of the disease and resistance to treatment. Local therapy of AS in children occupies a significant place. Currently, there are many methods and means of treating this disease of the oral mucosa, including the use of physiotherapy methods, antiseptic solutions, gels, ointments based on antibiotics, various combination drugs, taking sublingual tablets of aminodihydrophthalazinedione sodium (galavit) and others [A. Altenburg, N. El-Haj, C. Micheli, M. Puttkammer, M. B. Abdel-Naser, S. S. Zouboulis The treatment of chronic recurent oral aphtous ulcers. Deutsches Arzteblatt International journal. 2014; 111 (40): 665-673]. However, it's worth noting that these methods and medications have several drawbacks, including poor adhesion to oral tissues, rapid dissolution in oral fluid, and difficulty using the medication, including in children. Antibacterial medications also have serious side effects. The human oral cavity is home to over 700 species of microorganisms, including bacteria, actinomycetes, fungi, spirochetes, and viruses. Serious side effects include: oral dysbiosis, which means that antibiotics, when administered to the body, do not selectively affect the microflora, thereby destroying not only pathogenic but also healthy microflora, creating a significant imbalance in the oral microbiome, causing significant discomfort to patients; immediate and delayed allergic reactions; frequent administration of antibacterial medications can lead to the development of persistent resistance to antibiotic therapy, significantly reducing the effectiveness of the medication. A known method for the local treatment of aphthous stomatitis in children, adopted as a prototype, consists of using a bacteriophage in the form of mouth baths. For this, a solution of purified polyvalent pyobacteriophage (NPO Mikrogen, Ufa) is taken into the mouth and kept for 10 minutes after meals, 3 times a day for 10 days. To improve the therapeutic effect, it is recommended to abstain from food for one hour [Experience using bacteriophages in the complex treatment of children with aphthous stomatitis. Rabinovich I.M., Gileva O.S., Akmalova G.M., Mannapova G.R., Epishova A.A., Gimranova I.A. Dentistry. 2022. Vol. 101. No. 6. Pp. 22-27]. The prototype has the following disadvantages. When treating young children, mouthwashes are difficult for children due to their age, and they often swallow the solution. Excessive salivation in children can disrupt the medication's adhesion to the oral tissues; the medication is washed away by oral fluid, thereby failing to create the desired concentration in the affected area. If aphthae are located in hard-to-reach areas, applying the medication to these are