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RU-2861531-C1 - METHOD FOR PREDICTING VITAMIN D DEFICIENCY IN NEWBORN INFANTS

RU2861531C1RU 2861531 C1RU2861531 C1RU 2861531C1RU-2861531-C1

Abstract

FIELD: medicine. SUBSTANCE: invention relates to neonatology and paediatrics, and can be used for predicting vitamin D deficiency in newborn infants. During pregnancy in the mother, in the third trimester, a quantitative determination of 25(OH)D in the blood serum is carried out. The probability of vitamin D deficiency in the newborn infant is calculated using the claimed formula, taking into account the mother's age and the birth order number of the mother. If the calculated probability is above 0.5, the presence of vitamin D deficiency in the newborn infant is predicted. If the calculated probability is below 0.5, the absence of vitamin D deficiency in the newborn infant is predicted. EFFECT: possibility of simple, effective, low-cost prediction of vitamin D deficiency in newborn infants, by examining the maternal serum level of 25(OH)D and determining the low supply of vitamin D in the newborn. 1 cl, 1 tbl, 2 ex

Inventors

  • Kosinova Svetlana Romanovna
  • PETRUSHINA ANTONINA DMITRIEVNA

Dates

Publication Date
20260505
Application Date
20251202

Claims (9)

  1. A method for predicting hypovitaminosis D in newborns is characterized by the fact that during the third trimester of pregnancy, the mother undergoes a quantitative determination of 25(OH)D in the blood serum and the probability of the occurrence of hypovitaminosis D in the newborn is calculated using the formula:
  2. , Where
  3. y = 7.582 - 0.163×ХВИТДм - 0.129×ХВИРм + 0.606×ХБИРм;
  4. P – probability of vitamin D deficiency, %;
  5. e – Euler's number;
  6. ХВИТDм – level of 25 (OH) D in the mother, ng/ml;
  7. ХВОЗРм – mother’s age, in full years;
  8. ХБЕРм – ordinal number of the mother’s pregnancy,
  9. then, if the calculated probability is higher than 0.5, the presence of hypovitaminosis D in the newborn child is predicted, and if the calculated probability is lower than 0.5, the absence of hypovitaminosis D in the newborn child is predicted.

Description

The invention relates to the field of medicine, namely neonatology and pediatrics, and can be used to predict the condition of a newborn child exposed to various environmental conditions, and the individual risk level for the development of hypovitaminosis D. Vitamin D is a prohormone with receptors in all organs and systems. Maternal 25(OH)D status is a critical factor affecting fetal development in the prenatal period and plays a multifactorial role in the development of all organs and systems. However, 54% of pregnant women and 75% of newborns worldwide have vitamin D deficiency, with severe deficiency (25(OH)D less than 10 ng/ml) being diagnosed in 18% and 29% of cases, respectively [1. Borovik T.E., Gromova O.A., Zakharova I.N., et al. Vitamin D Deficiency in Children and Adolescents of the Russian Federation: Modern Approaches to Correction. National Program. 2nd ed. Moscow, 2021. 2. Zakharova I.N., Maltsev S.V., Zubkov V.V. Vitamin D, low-birth-weight, preterm, and full-term infants: time for a paradigm shift. RMJ. Mother and Child. 2020;3(2):142–148. DOI: 10.32364/2618-8430-2020-3-2-142-148. 3. Ideraabdullah, F. Y., Belenchia, A. M., Rosenfeld, C. S., Kullman, S. W., Knuth, M., Mahapatra, D., Bereman, M., Levin, E. D., & Peterson, C. A. (2019). Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD). Journal of Endocrinology, 241(2), R65–R80. Retrieved Sep 28, 2023, from https://doi.org/10.1530/JOE-18-0541]. This, in turn, may lead to an increase in acute and chronic socially significant diseases. The determination of the level of vitamin D (25OHD3) in the blood is a recognized criterion for assessing the exogenous provision of the child’s body with vitamin D [Maltsev S.V., Arkhipova N.N., Shakirova E.M. “Vitamin D, calcium and phosphates in healthy children and in pathology” Kazan Publishing House, 2012, 120 p.]. However, this method requires invasive intervention (venous blood sampling), is not covered by compulsory medical insurance, and is expensive. Diagnosis is known based on clinical signs: identification of characteristic symptoms of damage, mainly from the skeletal system, as well as the muscular, central and autonomic nervous systems [Strukov V.I. Rickets and osteoporosis: Monograph. Penza: Publishing house of Penza state university, 2004, 172 p.]. This method is not early and accurate; there may be cases of late diagnosis of low vitamin D status, when prophylactic doses of vitamin D are not effective. A comprehensive assessment of mineral metabolism is known – laboratory determination of phosphorus, serum calcium, magnesium, parathyroid hormone (PTH), and alkaline phosphatase in the blood serum. However, this method requires invasive intervention (venous blood sampling), and clinical manifestations of rickets/hypovitaminosis D in infants can be observed with normal levels of calcium and inorganic phosphorus in the blood. The use of instrumental diagnostics is known – radiography of long tubular bones [Novikov V.P. Rickets and hereditary rickets-like diseases in children: diagnostics, treatment, prevention. Moscow: “Triada-X”, 2006, 336 p.]. Adverse radiation exposure limits the use of this method in newborn children for predicting or monitoring the dynamics of preventive/therapeutic measures. A method is known for predicting the risk of developing rickets in children in the first months of life with functional insufficiency of the thyroid gland Authors: Strukov V. I., Maksimova M. N. (Patent for invention RU No. 2560847 C2 dated 01/09/2014, IPC G01N 33/74, published on 08/20/2015 Bulletin No. 23) in which a biochemical study of blood serum is carried out: the content of parathyroid hormone (PTH), calcitonin (CT) and vitamin D (25OHD3) is determined and they are considered in close relationship with the concentration of thyroid stimulating hormone (TSH) and thyroid hormone (free T4) at 1 month of life. The disadvantage of this method is that it is also invasive and is not intended to predict hypovitaminosis D in newborns. The objective of the present invention is to create a simple, effective, and inexpensive method for predicting hypovitaminosis D in newborns. The technical result is the prediction of hypovitaminosis D in newborn children based on a study of the serum level of 25(OH)D in the mother and the determination of low vitamin D status in the newborn. The specified technical result is achieved by conducting a quantitative determination of 25(OH)D in the mother's blood serum during pregnancy in the third trimester, and calculating the probability of hypovitaminosis D in the newborn child using formula 1: (1) where y = 7.582 - 0.163*ХВИТДм - 0.129*ХВИРм + 0.606*ХБЭРм P – probability of vitamin D deficiency; e – Euler's number; ХВИТDм – level of 25 (OH) D in the patient’s mother during pregnancy, ng/ml; XVOZRm – age of the patient’s mother, in full years; XBERm is the ordinal number of the patient's mother's pregnancy Further, if the calculated probabili