US-12616407-B2 - Shape-deformable and elastic bioadhesive electronic device and manufacturing method thereof

Abstract

One embodiment of the present invention provides a shape-deformable and elastic bioadhesive electronic device comprising a self-healing elastomeric polymer substrate, a stretchable thin-film electrode device, and a bioadhesive hydrogel layer. Another embodiment of the present invention provides a method for manufacturing a shape-deformable and elastic bioadhesive electronic device, comprising a transfer printing step of a thin-film electrode device onto a self-healing elastomeric polymer substrate; a substrate separation step of attaching an adhesive tape transferring the thin-film electrode device; an adhesive tape separation step of separating the adhesive tape from the self-healing elastomeric polymer; a pressurization and heat treatment step including heating the separated self-healing elastomeric polymer; and a bioadhesive hydrogel layer forming step of forming a bioadhesive hydrogel layer on a surface of the self-healing elastomeric polymer.

Inventors

• Donghee SON
• Mikyung Shin
• Sumin KIM
• Sungjun Lee

Assignees

• Research & Business Foundation Sungkyunkwan University

Dates

Publication Date

20260505

Application Date

20231117

Priority Date

20221117

Claims (7)

1. 1 . A shape-deformable and elastic bioadhesive electronic device comprising: a self-healing elastomeric polymer substrate; a stretchable thin-film electrode device; and a bioadhesive hydrogel layer, wherein the self-healing elastomeric polymer substrate is made of a self-healing elastomeric polymer material, wherein the stretchable thin-film electrode device defines an upper surface, a lower surface and a wall surface extending from the upper surface and the lower surface, wherein the stretchable thin-film electrode is disposed on the self-healing elastomeric polymer substrate and the self-healing elastomeric polymer substrate extends towards the wall surface and surrounds the wall surface and a portion of the upper surface to form an embedded-anchored electrode device, and wherein the bioadhesive hydrogel layer is formed by coating a bioadhesive hydrogel on the embedded-anchored electrode device.
2. 2 . The shape-deformable and elastic bioadhesive electronic device of claim 1 , wherein the self-healing elastomeric polymer material is a thermoplastic material.
3. 3 . The shape-deformable and elastic bioadhesive electronic device of claim 1 , wherein the self-healing elastomeric polymer material is a material that is elastic and capable of self-healing.
4. 4 . The shape-deformable and elastic bioadhesive electronic device of claim 1 , wherein the stretchable thin-film electrode device comprises a conductive pattern disposed on a surface of a substrate material, wherein the conductive pattern is formed by embossing or intaglio.
5. 5 . The shape-deformable and elastic bioadhesive electronic device of claim 1 , wherein the bioadhesive hydrogel layer is one or more materials selected from the material groups that are able to be manufactured in a film form and are able to be hydrogelated in a moisture environment, among natural polymers containing aromatic substances and phenols.
6. 6 . The shape-deformable and elastic bioadhesive electronic device of claim 1 , wherein a biological tissue to which the shape-deformable and elastic bioadhesive electronic device is applicable is one or more selected from the group consisting of brain tissue, spinal cord tissue, heart tissue, peripheral nerve tissue, vagus nerve tissue, and muscle tissue.
7. 7 . The shape-deformable and elastic bioadhesive electronic device of claim 1 , wherein the thin-film electrode device is a thin-film multi-channel electrode device.

Description

CROSS REFERENCE TO RELATED APPLICATION The present application claims priority to Korean Patent Application No. 10-2022-0154937, filed Nov. 17, 2022, the entire contents of which is incorporated herein for all purposes by this reference. BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to a shape-deformable and elastic bioadhesive electronic device and manufacturing method thereof, and more specifically, to a shape-deformable and elastic bioadhesive electronic device capable of conformal osculation to the curved structure of a cerebral cortex and solid adhesion to the tissue surface by incorporating a shape-deformable and elastic bioadhesive patch material, which consists a self-healing elastomeric polymer free to morph its physical shape and a bioadhesive hydrogel capable of tissue-specific adhesion, and a stretchable thin-film electrode device, and a method of manufacturing the same. Description of the Related Art Currently, the most advanced patch-type elastic bioelectronic device in the field of brain interfacing sensor technology has been generally manufactured by transfer printing and combining thin-film multi-channel electrode devices encapsulated with polyimide (PI) supports on an elastomeric polymer with surface viscosity and stickiness, such as polydimethylsiloxane (PDMS). However, due to the insufficient surface stickiness of the PDMS substrate, it was difficult to achieve uniformly adherent transfer printing of the polyimide thin-film device pattern, so there was a challenge that the unity of the substrate and the device could not be maintained and delaminated induced by repeated stretching. In addition, conventional stretchable elastomeric polymers such as PDMS do not have shape deformability or shape adaptability, so when used as bio-implantable electronic devices, the polymers do not adhere closely to the curvy-linear and complex structures of the cerebral cortex, and it is very difficult for the polymers to be firmly positioned on a wet brain surface, resulting in poor signal measurement and low on-site accuracy of multi-channel sensor devices and unstable biotic-abiotic interfacial impedance property. In addition, PDMS polymer, which is composed of irreversible covalent bonds, cannot sufficiently dissipate the stress induced by deformation when in contact with the curved cortical surface, thereby inflicting stress to the tissue, causing pressure, foreign body sensation, and discomfort when implanted in the body. Accordingly, in order to solve the above problems, the inventor has completed the invention of a shape-deformable and elastic bioadhesive electronic device, which is a new type of bioelectronic device that overcomes limitations of the conventional patch-type brain interfacing sensor device incapable of making conformal contact to the curved surface of the cerebral cortex and solid fixation of its position, by integrating micro-patterned stretchable thin-film multi-channel electrode devices onto a functional bilayer patch material that combines self-healing elastomeric polymers and bio-adhesive viscoelastomeric polymers, and a method of manufacturing the same. SUMMARY In order to solve the above problems, a technical objective to be achieved by the present invention is to provide a shape-deformable and elastic bioadhesive electronic device comprising a self-healing elastomeric polymer substrate, a stretchable thin-film electrode device, and a bioadhesive hydrogel layer, wherein the self-healing elastomeric polymer substrate is made of a self-healing elastomeric polymer material, in the stretchable thin-film electrode device, one surface and a wall surface connected to the one surface are embedded in the substrate, and a non-embedded wall surface and a portion of the other surface connected to the wall surface are anchored by the material of the substrate, and the bioadhesive hydrogel layer is formed by coating bioadhesive hydrogel on foreside of the embedding-anchoring electrode device. In order to solve the above problem, another technical objective to be achieved by the present invention is to provide a method for manufacturing a shape-deformable and elastic bioadhesive electronic device, comprising a transfer-printing step of a thin-film electrode device fabricated on a wafer onto a self-healing elastomeric polymer substrate; a substrate separation step of attaching an adhesive tape in a way that transfers the thin-film electrode device delaminated from the wafer to the self-healing elastomeric polymer printed; an adhesive tape separation step of separating the adhesive tape from the self-healing elastomeric polymer substrate on which the thin-film electrode device is printed and to which the adhesive tape is attached; a pressurization and heat treatment step including heating the separated self-healing elastomeric polymer substrate on which the thin-film electrode device is printed and applying pressure to the thin-film electrode device; and a bioa