US-12616408-B2 - Intravascular device

US12616408B2US 12616408 B2US12616408 B2US 12616408B2US-12616408-B2

Abstract

An intravascular device ( 1 ) is configured such that a first end section ( 1 a ) is disposed in a blood vessel of an organism, and an electrode for detection or stimulation of nerve tissue located outside the blood vessel is provided to the first end section ( 1 a ). The intravascular device ( 1 ) includes: an electrically-conductive wire member ( 10 ); at least one electrode member ( 20 ) that is provided on the first end section ( 1 a ) side and that is electrically connected to the wire member ( 10 ); and difference reduction sections ( 30, 40 ) that reduce a level difference caused by an outer diameter difference between the outer diameter of the electrode member ( 20 ) and the outer diameter of the wire member ( 10 ). The electrical resistance between the electrode member ( 20 ) and a second end section ( 1 b ) of the wire member ( 10 ), which is on the side opposite from the first end section ( 1 a ), is 100Ω or less.

Inventors

Hiroki Ishida
Yuji Matsumaru

Assignees

EPSILON MEDICAL INC.

Dates

Publication Date: 20260505
Application Date: 20231019
Priority Date: 20221021

Claims (11)

1 . An intravascular device having a first end portion configured to be disposed within a blood vessel of a living organism, and comprising, on a first end portion side, an electrode that is configured to detect or stimulate activity in nerve tissue located outside of the blood vessel, the intravascular device further comprising: a linear delivery member that is electrically conductive; at least one electrode member provided on the first end portion side and electrically connected to the linear delivery member; a first step-reducing portion that is configured to be at least partially disposed between the electrode member and the linear delivery member to reduce a size of a step due to an outer diameter difference between an outer diameter of the electrode member and an outer diameter of the linear delivery member; and a second step-reducing portion arranged on an outer side of the first step-reducing portion and adjacent to the first step-reducing portion, wherein an outer surface of the second step-reducing portion and the outer surface of the electrode member are configured to be substantially flush, wherein the intravascular device has an electrical resistance of 100Ω or less between the electrode member and a second end portion that is opposite to the first end portion of the linear delivery member, and wherein the electrode member is electrically connected to the linear delivery member only at a distal tip on the first end portion side of the electrode member.
2 . The intravascular device according to claim 1 , wherein the first step-reducing portion and the second step-reducing portion comprise at least one of a coiled member provided around the linear delivery member, or a tubular member composed of resin and provided around the linear delivery member.
3 . The intravascular device according to claim 2 , wherein at least a portion of the coiled member extends within the electrode member.
4 . The intravascular device according to claim 2 , wherein at least a portion of the tubular member extends over the coiled member, the tubular member being the second step-reducing portion, and the coiled member being the first step-reducing portion.
5 . The intravascular device according to claim 1 , wherein the electrode member is in a form of a helically wound metal wire.
6 . The intravascular device according to claim 1 , wherein the electrode member and the linear delivery member are fused to each other.
7 . The intravascular device according to claim 1 , wherein the intravascular device is placed in a blood vessel for one day or more.
8 . The intravascular device according to claim 1 , wherein the blood vessel, in which the intravascular device is disposed, is a cerebral vein.
9 . The intravascular device according to claim 1 , wherein the linear delivery member has a smaller diameter portion provided on the first end portion side, has a larger diameter portion provided on a second end portion side, and has a conical surface portion provided between the smaller diameter portion and the larger diameter portion, the larger diameter portion being larger than the smaller diameter portion, and wherein the at least one electrode member is provided on the smaller diameter portion of the linear delivery member.
10 . An intravascular device having a first end portion configured to be disposed within a blood vessel of a living organism, and comprising, on a first end portion side, an electrode that is configured to detect or stimulate activity in nerve tissue located outside of the blood vessel, the intravascular device further comprising: a linear delivery member that is electrically conductive; at least one electrode member provided on the first end portion side and electrically connected to the linear delivery member; and a step reducing portion that is configured to reduce a size of a step due to an outer diameter difference between an outer diameter of the electrode member and an outer diameter of the linear delivery member, wherein the linear delivery member has a smaller diameter portion provided on the first end portion side, has a larger diameter portion provided on a second end portion side, and has a conical surface portion provided between the smaller diameter portion and the larger diameter portion, the larger diameter portion being larger than the smaller diameter portion, wherein the outer diameter of the electrode member in a tip region of the electrode member, the tip region including a distal tip longitudinally aligned with the first end portion side, is configured such that a size of a step caused by an outer diameter difference between the outer diameter of the electrode member and the outer diameter of the linear delivery member reduces more than in a region other than the tip region of the electrode member, and wherein the intravascular device has an electrical resistance of 100Ω or less between the electrode member and a second end portion that is opposite to the first end portion of the linear delivery member.
11 . The intravascular device according to claim 10 , wherein the at least one electrode member is provided on the smaller diameter portion of the linear delivery member.

Description

TECHNICAL FIELD The present disclosure relates to an intravascular device configured to be used to detect or stimulate activity in nerve tissue. BACKGROUND ART In the related art, in a case in which brain waves of a living organism such as an animal or a human being are measured, electrodes are attached to a scalp of the living organism to perform transcranial measurements that measure the brain waves. According to this method, brain waves can be easily measured, but the method has the following drawbacks. Only information from a surface of a brain can be obtained, and thus only brain waves in a vicinity of the surface of the brain can be measured, and brain waves that are generated in a deep portion of the brain cannot be measured. Further, brain waves attenuate upon passing through the skull, thus accurate measurement is difficult. As a means for overcoming such disadvantages, Patent Document 1 discloses a device that is used to detect or stimulate activity in nerve tissue. CITATION LIST Patent Document Patent Document 1: Japanese Unexamined Patent Application, Publication No. 2022-121975 DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention However, in the device of Patent Document 1, electrodes are provided exposed from side surfaces of a core material and an insulator, and therefore it is difficult to stably manufacture the electrodes in an ultrafine outer shape so that the electrodes are insertable into, for example, a cerebral blood vessel. Further, in Patent Document 1, the configuration including a helical portion leads to a poor delivery property in a blood vessel. An object of the present disclosure is to provide an intravascular device that is configured to be used to detect or stimulate activity in nerve tissue, has an excellent delivery property to a blood vessel, and is highly sensitive for detection or stimulation. Means for Solving the Problems According to the present disclosure, it is possible to solve the above problems by the following solutions. To facilitate understanding, reference numerals that correspond to the embodiments of the present disclosure are given and described, and the present disclosure is not limited thereto. A first aspect of the present disclosure relates to an intravascular device (1, 1B, 1C, 1D) having a first end portion (1a) configured to be disposed within a blood vessel of a living organism, and comprising, on a first end portion (1a) side, an electrode that is configured to detect or stimulate activity in nerve tissue that is located outside of the blood vessel, the intravascular device further comprising: a linear delivery member (10) that is electrically conductive; at least one electrode member (20, 21, 22) provided on the first end portion (1a) side and electrically connected to the linear delivery member (10); and a step-reducing portion (30, 40, 70) that is configured to reduce a size of a step due to an outer diameter difference between an outer diameter of the electrode member (20, 21, 22) and an outer diameter of the linear delivery member (10). The intravascular device (1, 1B, 1C, 1D) has an electrical resistance of 100Ω or less between the electrode member (20, 21) and a second end portion (1b) that is opposite to the first end portion (1a) of the linear delivery member (10). A second aspect of the present disclosure relates to the intravascular device (1, 1C) according to the first aspect, in which the step-reducing portion (30, 40) comprises at least one of a coiled member (30) provided around the linear delivery member (10), a twisted linear member (80) provided around the linear delivery member (10) or along the linear delivery member (10), or a tubular member (40) composed of resin and provided around the linear delivery member (10). A third aspect of the present disclosure relates to the intravascular device (1, 1C) according to the second aspect, in which at least a portion of the coiled member (30) extends within the electrode member (20, 21). A fourth aspect of the present disclosure relates to the intravascular device (1, 1C) according to the second aspect or the third aspect, in which at least a portion of the tubular member (40) extends over the coiled member (30). A fifth aspect of the present disclosure relates to the intravascular device (1D) according to the first aspect, in which the electrode member (22) and the linear delivery member (10) are disposed apart from each other, and the electrode member (22) and the linear delivery member (10) are electrically connected to each other by an electrical conductor (80). A sixth disclosure of the present disclosure relates to the intravascular device (1D) according to the fifth disclosure, in which the electrical conductor (80) is a coiled wire or a twisted wire. A seventh disclosure of the present disclosure relates to the intravascular device (1, 1B) according to any one of the first disclosure to the fourth disclosure, in which the electrode member (20) is in a form of a he