US-12616602-B2 - Bacteria formulation and products including same

Abstract

A bacteria formulation includes bacteria including odor neutralizing bacteria configured to oxidize hydrogen sulfide and/or methyl mercaptan and one or more compounds for supporting viability of the bacteria.

Inventors

• Tadas S. Sileika
• Mark W. Jockel
• Nicole L. Dean

Assignees

• HOLLISTER INCORPORATED

Dates

Publication Date

20260505

Application Date

20210804

Claims (14)

1. 1 . An ostomy system comprising: an ostomy pouch having opposed sidewalls forming an enclosed area configured to receive and store stomal effluent and a pouch filter connected to one of the sidewalls; an ostomy appliance configured to be adhered to a user's skin; and a bacteria formulation comprising bacteria including odor neutralizing bacteria and one or more compounds for supporting viability of the bacteria, wherein the bacteria formulation comprises a first bacteria formulation configured to provide pH in a range of 2-3 and a second bacteria formulation configured to provide pH in a range of 6-8; wherein the pouch filter comprises a filter element comprising a first section and a second section, the first bacteria formulation is provided at the first section, and the second bacteria formulation is provided at the second section.
2. 2 . The ostomy system of claim 1 , wherein the bacteria formulation is disposed in the enclosed area of the ostomy pouch.
3. 3 . The ostomy system of claim 1 , wherein the pouch filter includes the bacteria formulation.
4. 4 . The ostomy system of claim 3 , wherein the pouch filter does not comprise activated carbon.
5. 5 . The ostomy system of claim 1 , wherein the bacteria further include probiotic bacteria for providing an antimicrobial effect.
6. 6 . The ostomy system of claim 5 , wherein the ostomy pouch comprises a pouch film which includes the bacteria formulation.
7. 7 . The ostomy system of claim 5 , wherein the ostomy pouch comprises a comfort panel which includes the bacteria formulation.
8. 8 . The ostomy system of claim 5 , wherein the ostomy appliance comprises a skin contacting adhesive which includes the bacteria formulation.
9. 9 . The ostomy system of claim 1 , wherein the odor neutralizing bacteria are one or more of: Thiobacillus sp., Thiobacillus denitrificans, Thiobacillus ferrooxidans, Thiobacillus thiooxidans, Thiobacillus novellus, Thiobacillus thioparus, Thermothrix azorensis, Thiothrix nivea, Thioalkalispira microaerophila and Thiomicropira frisia.
10. 10 . The ostomy system of claim 5 , wherein the probiotic bacteria are one or more of: Lactobacillus spp, Lactococcus, Leuconostoc, Bifidobacterium and Saccharomyces.
11. 11 . The ostomy system of claim 1 , wherein the first bacteria formulation is configured to convert hydrogen sulfide to a neutralized variant and the second bacteria formulation is configured to convert methyl mercaptan to a neutralized variant.
12. 12 . The ostomy system of claim 1 , wherein the one or more compounds for supporting viability of the bacteria include one or more of a nutrient, a buffering agent and/or a supplement.
13. 13 . The ostomy system of claim 1 , wherein the bacteria formulation further comprises photosynthetic bacteria.
14. 14 . The ostomy system of claim 1 , wherein the bacteria formulation further comprises Beggiatoa spp.

Description

This is a National Stage Application of International Patent Application No. PCT/US2021/044457 filed Aug. 4, 2021, which claims the benefit of and priority to U.S. Provisional Application No. 63/062,013 filed Aug. 6, 2020, the entirety of which are incorporated fully herein by reference. BACKGROUND The following description relates generally to bacteria formulations, and in particular, to odor neutralizing and probiotic bacteria formulations which may be used, for example, in medical products such as ostomy pouch systems and skin contacting adhesives. An ostomy pouch system typically includes a pouch formed from opposing sidewalls defining an internal collection area, an inlet opening for receiving a stoma, and an ostomy appliance for attaching the pouch to a user. The ostomy appliance may include, for example, an ostomy barrier of a one-piece pouch system, which is attached to one of the pouch sidewalls proximate an inlet opening, a faceplate for a two-piece pouch system configured to releasably engage a pouch, and a barrier ring. The ostomy appliance may include a skin barrier material for adhering to and sealing against user's peristomal skin surrounding the stoma. Ostomy pouch systems may produce odors from stomal effluent stored in the ostomy pouch. The odors may be vented from the ostomy pouch to the atmosphere. It is desirable to neutralize or minimize odors associated with use of the ostomy pouch system. To this end, an ostomy pouch may include a filter configured to deodorize gas vented from the pouch. In addition, body odors may be produced at an interface of a skin contacting surface of a medical product and the user's body as a result of moisture between the skin contacting surface and the user's body. Further, a user may be susceptible to skin infections where the skin contacting surface contacts the skin. Conventional ostomy pouch filters may be relatively expensive and may not deodorize vented gas sufficiently. As a result, odors associated with vented gas may be detected by the user or others in the vicinity of the user. In addition, a user may attempt to minimize body odors by frequent cleansing and replacement of products having skin contacting surfaces. However, frequent cleansing may be tedious, time consuming, and cause skin irritation. Frequent replacement of products having skin contacting surfaces may result in inefficient use of the products. Skin infections may lead to user discomfort and may cause complications. Accordingly, it is desirable to provide an odor neutralizing bacteria formulation and an odor neutralizing and probiotic bacteria formulation which may be used with medical products such as ostomy pouch systems or skin contacting adhesives. SUMMARY In one aspect, a bacteria formulation includes bacteria including odor neutralizing bacteria configured to oxidize hydrogen sulfide and/or methyl mercaptan, and one or more compounds for supporting viability of the bacteria. In an embodiment, the odor neutralizing bacteria may be chemotrophic bacteria. The odor neutralizing bacteria may be one or more of: Thiobacillus sp., Thiobacillus denitrificans, Thiobacillus ferrooxidans, Thiobacillus thiooxidans, Thiobacillus novellus, Thiobacillus thioparus, Thermothrix azorensis, Thiothrix nivea, Thioalkalispira microaerophila and Thiomicrospira frisia. In an embodiment, the one or more compounds may include one or more of a nutrient, a buffering agent and/or a supplement. In an embodiment, the bacteria formulation may further include photosynthetic bacteria. In an embodiment, the bacteria formulation may further include Beggiatoa spp. In an embodiment, the bacteria may further include probiotic bacteria for providing an antimicrobial effect. The probiotic bacteria may be one or more of: Lactobacillus spp, Lactococcus, Leuconostoc, Bifidobacterium and Saccharomyces. In an embodiment, the bacteria and the one or more compounds may interact to provide pH in a range of about 2-3. In an embodiment, the bacteria and the one or more compounds may interact to provide pH in a range of about 6-8. In another aspect, an ostomy system includes an ostomy pouch having opposed sidewalls forming an enclosed area configured to receive and store stomal effluent and a pouch filter connected to one of the sidewalls. The ostomy system further includes an ostomy appliance configured to be adhered to a user's skin, and a bacteria formulation having bacteria including odor neutralizing bacteria and one or more compounds for supporting viability of the bacteria. In an embodiment, the bacteria formulation may be disposed in the enclosed area of the ostomy pouch. In an embodiment, the pouch filter may include the bacteria formulation. In an embodiment, the pouch filter does not include activated carbon. In an embodiment, the bacteria may further include probiotic bacteria for providing an antimicrobial effect. In an embodiment, the ostomy pouch may include a pouch film which includes the bacteria formulation. In a