US-12616649-B2 - Composition containing plant extracts

Abstract

The present invention relates to a composition comprising plant extracts. The composition according to the present invention has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in melanocytes of the skin, promotes skin regeneration and increases skin elasticity or reduces skin wrinkles by promoting collagen synthesis and inhibiting collagenase activity in fibroblasts of the skin, has an anti-inflammatory effect or a skin soothing effect by inhibiting NO generation, increases the amount of moisture in the skin and has a moisturizing effect by promoting generation of hyaluronic acid in fibroblasts, and has an antioxidant effect by scavenging free radicals. In addition, since the composition of the present invention exhibits a broad antibacterial effect against various bacteria, the composition may be used as a cosmetic composition, a pharmaceutical composition, a skin external preparation, or a food composition.

Inventors

• So Young Lee
• Jung Ha CHOO
• Hong Gu Lee
• Jun Hyeong Park
• Jae Hee Kim
• Yun Hee CHANG
• Gil Nam KIM
• Ji Hyun Seo
• Young Je Ahn
• Ji Hyung KIM
• Mu Hyun Jin
• Gwang Jin Lee
• Jeong Eun Kim

Assignees

• LG HOUSEHOLD & HEALTH CARE LTD.

Dates

Publication Date

20260505

Application Date

20210104

Priority Date

20200102

Claims (9)

1. 1 . A method of skin-moisturizing, which comprises applying a composition for moisturizing skin to the skin of a patient in need of treatment of a dry skin disease, wherein the composition comprises an effective amount of a plant extract comprising Cirsium nipponicum as an active ingredient.
2. 2 . The method according to claim 1 , wherein the plant extract comprises substances extracted from the plant using water, an organic solvent, or a mixture thereof.
3. 3 . The method according to claim 2 , wherein the organic solvent is a low-grade alcohol having 1 to 6 carbon atoms, a polyhydric alcohol, a hydrocarbon-based solvent, or a mixture thereof.
4. 4 . The method according to claim 1 , wherein, based on 100 parts by weight of the composition, the plant extract is comprised in an amount of 0.0001 to 10 parts by weight.
5. 5 . The method according to claim 1 , wherein the composition is a cosmetic composition.
6. 6 . The method according to claim 1 , wherein the composition is a pharmaceutical composition.
7. 7 . The method according to claim 1 , wherein the composition is a skin external preparation.
8. 8 . The method according to claim 1 , wherein the plant extract comprises a combination of Cirsium nipponicum and Anthriscus sylvestris.
9. 9 . The method according to claim 1 , wherein the dry skin disease is one or more of atopic dermatitis or psoriasis.

Description

CROSS REFERENCE TO RELATED APPLICATIONS This application is the National Phase of PCT International Application No. PCT/KR2021/000033, filed on Jan. 4, 2021, which claims priority under 35 U.S.C. 119(a) to Patent Application No. 10-2020-0000282, filed in the Republic of Korea on Jan. 2, 2020, all of which are hereby expressly incorporated by reference into the present application. TECHNICAL FIELD The present invention relates to a composition containing plant extracts, and more particularly, to a composition for skin whitening, skin regeneration, elasticity improvement, wrinkle suppression, inflammation suppression, skin soothing, skin moisturizing, oxidation inhibition, or bacterial inhibition. BACKGROUND ART Most people want to have fair skin. Skin color is genetically determined according to the concentration and distribution of melanin in the skin, but skin color is also affected by environmental factors such as ultraviolet rays and physiological factors such as fatigue and stress. Melanin is produced through a non-enzymatic oxidation reaction after tyrosine, a type of amino acid, is converted to dopa and dopaquinone by action of a tyrosinase enzyme. As such, the pathway by which melanin is produced is known, but the previous step of the step in which tyrosinase acts, that is, the mechanism of inducing melanin synthesis, is still unknown. Examples of general whitening ingredients comprise substances that inhibit tyrosinase enzyme activity, such as kojic acid and arbutin, hydroquinone, vitamin-C (L-ascorbic acid) and derivatives thereof, and various plants extracts. The above-described whitening ingredients may lighten skin tone by inhibiting synthesis of a melanin pigment, thereby realizing skin whitening. In addition, the whitening ingredients may alleviate skin hyperpigmentation, such as melasma or freckles, caused by ultraviolet rays, hormones, or heredity. However, when the whitening ingredients are applied to the skin, usage thereof may be limited due to safety issues such as irritation and redness. In addition, in some cases, since the effect of the whitening ingredients is insignificant, a substantial effect may not be expected for the whitening ingredients. Meanwhile, collagen is a major matrix protein produced by fibroblasts of the skin and is present in the extracellular matrix. Collagen is responsible for maintaining the mechanical strength of the skin, imparting resistance and bonding strength to the connective tissues, maintaining cell adhesion, and inducing cell division and differentiation (in growth of an organism or wound healing). Collagen decreases with age and photoaging caused by UV irradiation, which is known to be closely related to formation of wrinkles in the skin. Also, in recent years, as extensive research on skin aging progresses, new functions of collagen in the skin are being revealed. Active ingredients that promote collagen synthesis and exhibit anti-wrinkle effects are known. For example, retinoic acid, a transforming growth factor (TGF) [Non-Patent Document 1], an animal placenta-derived protein [Patent Document 1], betulinic acid [Patent Document 2], and chlorella extracts [Patent Document 3, 4] are known as collagen synthesis promoting substances. However, when the active ingredients are applied to the skin, usage thereof may be limited due to safety issues such as irritation and redness. In addition, in some cases, since the effect of the active ingredients is insignificant, the effect of improving the skin function by promoting synthesis of collagen in the skin may be substantially insignificant. Meanwhile, inflammation is an immune response of the human body in response to a wound or disease, and ultraviolet rays or oxidative stress due to reactive oxygen species or free radicals activates inflammatory factors to cause various diseases and aging of the skin. Vasoactive polypeptides such as kinin, plasmin, and complements play a role in vasodilation, vasoconstriction, and chemotaxis. In addition, lymphokines, such as interleukin-6 (IL-6), and arachidonic acid are responsible for inflammatory responses. Arachidonic acid is converted to prostaglandins and leukotrienes, which are inflammatory mediators, through two pathways associated with cyclooxygenase and lipooxygenase, and mediates various inflammatory responses. Anti-inflammatory agents serve to eliminate inflammation by removing inflammatory sources and reducing biological responses and symptoms. To date, substances used for anti-inflammatory purposes comprise non-steroidal substances such as flufenamic acid, ibuprofen, benzydamine, and indomethacin and steroidal substances such as prednisolone and dexamethasone. In addition, allantoin, azene, hydrocortisone, and the like are known to have an anti-inflammatory effect. However, usage thereof may be limited due to skin safety issues, and the effect of alleviating inflammation by these substances may be insignificant. Meanwhile, hyaluronic acid is a type of glycosa