US-12616727-B2 - Compositions, systems, and methods for improving health

Abstract

Provided herein are product combinations, methods, kits, and compositions related to improving health and well-being in a subject. Methods of improving health and well-being may include ingesting a yerba mate supplement after waking, fasting for a fasting interval, and ingesting a fiber supplement before meal consumption.

Inventors

• Stewart Hughes

Assignees

• UNICITY PROPERTIES, INC.

Dates

Publication Date

20260505

Application Date

20230629

Claims (20)

1. 1 . A composition for improving health or well-being, the composition comprising: a yerba mate supplement comprising at least 20% total chlorogenic acids, at least 0.3% theobromine, and 1-6% caffeine, wherein the yerba mate supplement comprises: at least 600 mg total chlorogenic acids; at least 9 mg theobromine; and about 60-180 mg caffeine; and a fiber supplement comprising at least 3.5 g soluble fiber and 250-1000 mg phytosterols.
2. 2 . The composition of claim 1 , wherein the soluble fiber comprises guar gum, locust bean gum, citrus pectin, oat fiber, beta-glucans, or gum arabic.
3. 3 . The composition of claim 1 , wherein the fiber supplement further comprises vitamin A, vitamin C, vitamin E, thiamin, riboflavin, niacinamide, pyridoxine HCl, folic acid, cyanocobalamin, biotin, calcium carbonate, zinc gluconate, chromium, a polyphenol blend, magnesium oxide, pantothenic acid, or short-chain fructo-oligosaccharides.
4. 4 . The composition of claim 1 , wherein the yerba mate supplement and the fiber supplement are formulated as a powder or a drink.
5. 5 . The composition of claim 1 , wherein the yerba mate supplement and the fiber supplement are formulated for oral ingestion.
6. 6 . The composition of claim 1 , wherein the yerba mate supplement and the fiber supplement are packaged separately.
7. 7 . The composition of claim 1 , wherein the yerba mate supplement and the fiber supplement are formulated for ingestion at different time intervals.
8. 8 . The composition of claim 1 , wherein the yerba mate supplement is formulated for ingestion at least once daily.
9. 9 . The composition of claim 1 , wherein the fiber supplement is formulated for ingestion at least twice daily.
10. 10 . The composition of claim 1 , wherein the yerba mate supplement comprises at least 60 mg caffeine.
11. 11 . The composition of claim 1 , wherein the yerba mate supplement comprises about 600 mg of total chlorogenic acids, about 9 mg of theobromine, and about 120 mg of caffeine.
12. 12 . A method for improving health or well-being in a subject, comprising: fasting for a fasting interval of about 12-18 hours; ingesting a yerba mate supplement during the fasting interval; ingesting a fiber supplement following the fasting interval; and wherein improving health or well-being comprises improving blood lipid levels, reducing body weight, reducing fasting blood sugar levels, increasing feelings of positive experiences, or decreasing feelings of negative experiences.
13. 13 . The method of claim 12 , wherein the yerba mate supplement comprises at least 600 mg of total chlorogenic acids.
14. 14 . The method of claim 12 , wherein the yerba mate supplement comprises at least 9 mg of theobromine.
15. 15 . The method of claim 12 , wherein the yerba mate supplement comprises 60-180 mg of caffeine.
16. 16 . The method of claim 12 , further comprising mixing the fiber supplement or the yerba mate supplement with a liquid.
17. 17 . The method of claim 16 , wherein the liquid is water.
18. 18 . The method of claim 16 , wherein the liquid is tea.
19. 19 . The method of claim 16 , wherein the liquid is an electrolyte solution.
20. 20 . The method of claim 16 , wherein the liquid is in an amount ranging from about 200 mL to about 800 mL.

Description

INCORPORATION BY REFERENCE This application claims the benefit of U.S. Provisional Application No. 63/358,031, filed Jul. 1, 2022. The aforementioned application is incorporated by reference herein in its entirety. FIELD The present disclosure generally relates to product combinations, methods, kits, and compositions for improving health and well-being using a yerba mate supplement and a fiber supplement, and to methods, kits, and compositions for improving health and well-being by fasting for a fasting interval in combination with the compositions and product combinations described herein. BACKGROUND An epidemic of obesity and related cardiometabolic diseases, driven by poor diet and sedentary lifestyle, is spreading rapidly worldwide. A diet rich in dietary fiber can lower blood cholesterol levels and better manage blood glucose levels. In addition, high-fiber foods tend to provide better satiety, which aids in reducing calorie consumption. Yerba mate, or Ilex paraguariensis, is one of the most commercialized medicinal plants of South America. It grows naturally and is cultivated in Argentina, Uruguay, Brazil, and Paraguay. The component parts of this plant are used to prepare a tea-like beverage (Croge et al., 2020). Yerba mate also has a long history of use worldwide. In Europe it is used for weight loss, physical and mental fatigue, nervous depression, rheumatic pains, and psychogenic- and fatigue-related headaches. In Germany, it has become popular as a weight-loss aid. Yerba mate is the subject of a German monograph, which lists its approved uses for mental and physical fatigue, and describes it as having analeptic, diuretic, positively inotropic, positively chronotropic, glycogenolytic, and lipolytic effects. In France, yerba mate is approved for the treatment of asthenia (weakness or lack of energy), as an aid in weight-loss programs, and to increase the renal excretion of water. It also appears in the British Herbal Pharmacopoeia (1996), with indications for the treatment of fatigue, weight loss, and headaches. In the U.S., yerba mate was recommended for arthritis, headache, hemorrhoids, fluid retention, obesity, fatigue, stress, constipation, allergies, and hay fever, and is used to cleanse the blood, tone the nervous system, retard aging, stimulate the mind, control the appetite, stimulate the production of cortisone, and is believed to enhance the healing powers of other herbs. Yerba mate is also cultivated in India, and the Indian Ayurvedic Pharmacopoeia lists maté for the treatment of psychogenic headaches, nervous depression, fatigue, and rheumatic pains (Heck & De Mejia, 2007). The primary known bio-active chemical constituents of yerba mate include xanthine alkaloids, chlorogenic acids, and mate saponins. Xanthine alkaloids include, for example, caffeine (1,3,7-trimethylxanthine), theobromine (3,7-dimethylxanthine), and theophylline (1,3-dimethylxanthine), and analogues or derivatives thereof. Chlorogenic acids include, for example, caffeic acid and tannins, and analogues or derivatives thereof (Oellig et al., 2018). The content of yerba mate leaf has been assayed and reported to contain between caffeine by weight, 0.3%-0.9% theobromine by weight, theophylline in relatively minor amounts, saponins, and 10% caffeic acid derivatives (chlorogenic acid, caffeic acid, 3,4-dicaffoylquinic acid, 3,5-dicaffoylquinic acid and 4,5-dicaffoylquinic acid) (Matei et al., 2016). Other chemicals found in yerba mate include alpha-amyrin, alpha-terpineol, arachidic acid, beta-amyrin, butyric acid, 5-o-caffeoylquinic acid, calcium, carotene, choline, chlorophyll, cyanidin-3-o-xylosyl-glucoside, cyanidin-3-glucoside, essential oil, eugenol, geraniol, geranyl acetone, guayacan b, indole, inositol, ionone, iso-butyric acid, iso-caproic acid, iso-chlorogenic acid, iso-valeric acid, kaempferol, lauric acid, levulose, linalool, linoleic acid, maté saponins, neochlorogenic acid, nerolidol, nicotinic acid, nudicaucin c, octan-1-ol, octanoic acid, oleic acid, palmitic acid, palmitoleic acid, pyridoxine, quercetin, raffinose, safrole, stearic acid, tannins, theobromine, theophylline, trigonelline, and ursolic acid. In addition, 7%-14% of tannins were also reported in yerba mate leaf material (Bastos et al., 2007; Bojić et al., 2013; Burris et al., 2012; Chandrasekara & Shahidi, 2018; Chianese et al., 2019; Ferreira Cuelho et al., 2015; Frizon et al., 2018; Isolabella et al., 2010; Junior & Morand, 2016; Puangpraphant, 2012; Riachi et al., 2018; Souza et al., 2015). Theobromine is used as a vasodilator, a diuretic, and a heart stimulator. Theobromine is recognized as an antagonist of the adenosine receptor, similar to caffeine, and an inhibitor of phosphodiesterase, and may be helpful in the management of fatigue and orthostatic hypotension. SUMMARY The present disclosure generally relates to product combinations, methods, kits, and compositions for improving health and well-being using a yerba mate supplement and a fi