US-12616731-B2 - Process for enhancing organoleptic properties of natural products and natraceuticals thereof

US12616731B2US 12616731 B2US12616731 B2US 12616731B2US-12616731-B2

Abstract

A method for increasing functional and organoleptic properties of compositions having elements of biological origin more particularly herbal formulations is disclosed. Nutraceutical formulations for diabetes management and fortification of pulses and grains to lower oil absorption during frying are also disclosed. These foods are effective for weight management.

Inventors

Vr. RAMANATHAN
Siva VALLABHANENI
V. RAJALAKSHMI

Assignees

DIABLISS CONSUMER PRODUCTS PVT LTD

Dates

Publication Date: 20260505
Application Date: 20210922
Priority Date: 20200925

Claims (11)

1 . A method for manufacturing a formulation of natural products comprising herbs, plants and/or spices and/or part thereof, with enhanced functional and organoleptic properties, said method comprising: drying herbs and/or spices to achieve a moisture content of 5% to 25%, wherein the herbs and/or spices are selected from Coriandrum sativum L., Illicium verum, Curcuma longa, Cuminum cyminum, Nigella sativa, Trigonella foenum - graecum, Piper nigrum, Syzygium aromaticum, Zingiber officinale, Phyllanthus emblica, Syzygium cumini, Cinnamomum verum, Senna alexandrina; Psidium guajava, Trachyspermum ammi , or Foeniculum vulgare. grinding the herbs and/or spices to a resultant powder having a particle size of about 30 microns to about 300 microns; homogenizing the resultant powder mixture with water into a slurry, by dissolving the powder mixture in water, followed by keeping it in a jacketed stirred tank for about 4 to about 16 hours at a temperature of 25° C. to 60° C. to form a slurry; and distilling or filtering the slurry selected from: (i) distilling of the slurry and collecting a condensate therefrom; or (ii) filtering the slurry under pressure to obtain a filtrate and distilling the filtrate and collecting the condensate wherein distilling the filtrate and/or distilling the remaining slurry is performed in vacuum between 0.01 torr to 300 torr, and removing color and taste causing compounds to obtain the formulation of natural products.
2 . The method as claimed in claim 1 , wherein the grinding is by hammer mill or commercial food shredder pulveriser.
3 . The method as claimed in claim 2 , wherein the hammer mill is operated between 1500 RPM y 2000 RPM.
4 . The method as claimed in claim 1 , wherein the filtrate is subjected to either: contacting the filtrate with activated carbon with a BET surface area of 500-1,700 sq metres per gram for a period of 30-60 minutes at a temperature of 35-65 deg C, to obtain the formulation of natural products; or contacting the filtrate in an ion-exchange column with anionic polymers selected from the group consisting of microporous grade polystyrenic strong base type I anion exchanger having quarternary ammonium functional groups, non-ionic polydivinyl benzene adsorbant resins, and styrene matrix and acrylic matrix resins with BET surface area of 500-1,200 sq metres per gram; and removing color and taste causing compounds after contact with the activated carbon or the anionic polymers to obtain the formulation of natural products.
5 . The method as claimed in claim 1 , wherein distilling the filtrate is performed in a rotary evaporator immersed in a heated water bath or a water and glycol bath.
6 . The method as claimed in claim 5 , wherein the evaporator is rotated at 40-70 rpm, and optionally fitted with a condenser cooled with chilled water or a water and glycol mixture.
7 . The method as claimed in claim 1 , wherein distilling the remaining slurry is by glass batch distillation.
8 . The method as claimed in claim 7 , wherein the glass batch distillation apparatus comprises an impeller and is immersed in a heated oil batch or is a shell and tube condenser, which is chilled with water or a water and glycol mixture.
9 . The method as claimed in claim 7 , wherein the glass batch distillation is operated at vacuum levels between 0.01 torr to 100 torr with a residence time in a range of 3 hours to 12 hours.
10 . The method as claimed in claim 1 , wherein the distillation of the slurry is carried out by charging the slurry to an Agitated Thin Film Evaporator (ATFE) or Wet Film Evaporator (WFE).
11 . The method as claimed in claim 10 , wherein charging the slurry is performed under vacuum ranging from 0.01 torr to 100 torr for a residence time ranging from 1 second to 60 seconds.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS The present invention is filed under 35 U.S.C. § 371 as the U.S. national phase of International Patent Application No. PCT/IN2021/050933, filed Sep. 22, 2021, which designated the United States and which claims the benefit of India patent application Ser. No. 202041041780 filed Sep. 25, 2020, which is hereby incorporated in its entirety including all tables, figures, and claims. FIELD OF THE INVENTION The subject matter described herein, in general, relates to a method for increasing functional and organoleptic properties of compositions having elements of biological origin more particularly herbal formulations. It also discloses nutraceutical formulations for diabetes management and fortification of pulses and grains to lower oil absorption during frying, thus also making these foods effective for weight management. BACKGROUND OF THE INVENTION Diabetes mellitus is a chronic disease which is an incurable ailment and a better management is the only way for a better life. In Diabetes mellitus an increased level of glucose in the blood causes damage to many of the body's systems, particularly the blood vessels and the nerves. Both, Type 1 diabetes and Type 2 diabetes mellitus are complex diseases caused by mutations in more than one gene either inherited or a result of any environmental factor(s). Treatment of type 1 diabetes is based on daily administration of insulin. Type 2 diabetes or non-insulin dependent diabetes mellitus (NIDDM) is much more common and accounts for around 90% of all diabetes cases worldwide. It develops mostly in the adult age, but lately it has been also noted in young people, even in adolescents. Diabetes type 2 is strongly familial, but environmental factors play also an important role in the development of the disease. Healthy diet, practice of physical exercise and avoidance of overweight may prevent the disease and/or control its progress. People with type 2 diabetes require oral agents for satisfactory blood glucose control, but about one third needs insulin for reducing their blood glucose levels. Several complications are associated with diabetes including: (i) retinal and ophthalmic manifestations or dysfunctions such as retinopathy (ii) neuropathy consisting of peripheral nerves damages, feet pains, feet low pulse and edemas, blood circulation dysfunction, walking difficulties and legs wounds (iii) liver dysfunction consisting of hypercholesterolemia, proteinuria and hyperlipidemia, (iv) renal dysfunction—sometimes defined as Nephrotic syndrome consisting of lipiduria, hypercholesterolemia, hypoalbuminemia, edema, proteinuria, hyperlipidemia or microalbuminemia, prostate enlargement, ketones in urine, hypertension, and (vi) cardiovascular disease ranging from coronary artery disease to stroke or renal vascular disease, consisting of arterioscleroses, heart disease, valvular heart disease, disease of the heart muscle, arrythmias and noncoronary cardiovascular disease. People with diabetes are more prone to infection. They can also develop neuropathy (damaged nerves) or peripheral vascular disease (blocked arteries) of the legs and either can lead to foot ulceration. Infection and foot ulceration, alone or in combination, often lead to amputation. Neuropathy and peripheral vascular disease can also cause distressing pain in the lower limbs. Diabetes-related complications are a leading cause of death. Controlling blood sugar levels will help ensure that diabetes is managed successfully and reduce the risk of short and long-term complications that diabetes can cause like diabetic retinopathy, heart disease, which accounts for about 50% of all deaths among people with diabetes in industrialized countries, kidney failure, diabetic neuropathy, the most common complication of diabetes, that may lead to sensory loss and damage to the limbs, and to impotence in diabetic men and diabetic foot disease, one of the most common and costly complications of diabetes, that results from both vascular and neurological disease processes that often lead to ulceration and subsequent limb (mainly lower limb) amputation. Thus, in addition to the medicines and or insulin administration diabetes management is an essential aspect for avoiding and/or delaying short and long-term complications, managing dependence on medicines and for improving the quality of life. Nutraceuticals are emerging as one of the most promising management tools for diabetes. Naturally derived nutraceuticals from food ingredients provide functional property enhancements to foods in a healthy and safe manner Thus, there is a constant need for nutraceuticals to deal with various aspects of diabetes treatment and management like low fat absorbing foods to lower calorie intake for weight management benefits and provide safe and healthy alternatives. The current invention relates to a process of enhancing functional and organoleptic properties of natural products and nutraceuticals thereof. Mor