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US-12617710-B2 - Glass compositions with improved bioactivity

US12617710B2US 12617710 B2US12617710 B2US 12617710B2US-12617710-B2

Abstract

A silicate-based glass composition includes 15-65 wt. % SiO 2 , 15-50 wt. % CaO, 1-30 wt. % P 2 O 5 , and 1-20 wt. % ZrO 2 , such that the composition has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms a bioactive crystalline phase in simulated body fluid.

Inventors

  • Qiang Fu
  • Aize Li
  • Charisse Marye Spier

Assignees

  • CORNING INCORPORATED

Dates

Publication Date
20260505
Application Date
20221104

Claims (20)

  1. 1 . A silicate-based glass composition, comprising: 15-65 wt. % SiO 2 , 15-50 wt. % CaO, 10-30 wt. % P 2 O 5 , 1-20 wt. % ZrO 2 , and 0-7 wt. % MgO, wherein the composition has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms a bioactive crystalline phase in simulated body fluid.
  2. 2 . The glass composition of claim 1 , comprising: 15-45 wt. % SiO 2 , 30-50 wt. % CaO, and 2-15 wt. % ZrO 2 .
  3. 3 . The glass composition of claim 2 , further comprising 3-6 wt. % MgO.
  4. 4 . The glass composition of claim 2 , further comprising 10-20 wt. % SrO.
  5. 5 . The glass composition of claim 2 , further comprising 10-20 wt. % ZnO.
  6. 6 . The glass composition of claim 1 , further comprising >0-6 wt. % MgO.
  7. 7 . The glass composition of claim 1 , further comprising >0-25 wt. % SrO.
  8. 8 . The glass composition of claim 1 , further comprising >0-25 wt. % ZnO.
  9. 9 . The glass composition of claim 1 , wherein the glass comprises: 15-50 wt. % MO, and 0-30 wt. % R 2 O, wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO, and R 2 O is the sum of Na 2 O, K 2 O, Li 2 O, Rb 2 O, and Cs 2 O.
  10. 10 . The glass composition of claim 1 , wherein the bioactive crystalline phase comprises apatite.
  11. 11 . The glass composition of claim 10 , wherein the apatite is hydroxyapatite.
  12. 12 . The glass composition of claim 1 , wherein a sum of P 2 O 5 and CaO is from 25-65 wt. %.
  13. 13 . The glass composition of claim 1 , wherein the simulated body fluid is an artificial saliva.
  14. 14 . A matrix comprising the glass composition of claim 1 , wherein: the glass composition is attached to the matrix or mixed therein, and the matrix includes at least one of: a toothpaste, mouthwash, rinse, spray, ointment, salve, cream, bandage, polymer film, oral formulation, pill, capsule, or transdermal formulation.
  15. 15 . An aqueous environment comprising the glass composition of claim 1 .
  16. 16 . A silicate-based glass composition, comprising: 15-45 wt. % SiO 2 , 30-60 wt. % CaO, 10-30 wt. % P 2 O 5 , and 2-15 wt. % ZrO 2 , and 0-7 wt. % MgO, wherein the composition has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms an apatite crystalline phase in an artificial saliva, and wherein a sum of P 2 O 5 and CaO is from 25-65 wt. %.
  17. 17 . The glass composition of claim 16 , further comprising 3-6 wt. % MgO.
  18. 18 . The glass composition of claim 16 , further comprising 10-20 wt. % SrO.
  19. 19 . The glass composition of claim 16 , further comprising 10-20 wt. % ZnO.
  20. 20 . The glass composition of claim 16 , wherein the apatite is hydroxyapatite.

Description

CROSS REFERENCE TO RELATED APPLICATION This application claims the benefit of priority under 35 U.S.C. § 119 of U.S. Provisional Application Ser. No. 63/275,507 filed on Nov. 4, 2021, the content of which is relied upon and incorporated herein by reference in its entirety. FIELD This disclosure generally relates to glass compositions, and more particularly to bioactive glass compositions for consumer and dental applications. BACKGROUND Bioactive glasses are a group of glass and glass ceramic materials that have shown biocompatibility or bioactivity, which has allowed them to be incorporated into human or animal physiology. Generally speaking, bioactive glasses are able to bond with hard and soft tissues, thereby fostering growth of bone and cartilage cells. Moreover, bioactive glasses may also enable release of ions which activate expression of osteogenic genes and stimulate angiogenesis, as well as promote vascularization, wound healing, and cardiac, lung, nerve, gastrointestinal, urinary tract, and laryngeal tissue repair. Currently available bioactive glasses are being investigated for their ability to convert to apatite; however, the low chemical durability of these traditional bioactive glasses are problematic for compositions requiring prolonged shelf times in aqueous environments. For example, 45S5 Bioglass® requires development of a non-aqueous environment for glass particulates to be used in toothpaste applications. Other glass compositions (e.g., alkali-free glasses) do not exhibit the bioactivity of alkali-containing compositions. Thus, there continues to be an unmet need for bioactive glass compositions having high bioactivity while remaining chemically durable in aqueous environments. This disclosure presents glass compositions with improved bioactivity for consumer and dental applications. SUMMARY In embodiments, a silicate-based glass composition comprises 15-65 wt. % SiO2, 15-50 wt. % CaO, 1-30 wt. % P2O5, and 1-20 wt. % ZrO2, wherein the composition: has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms a bioactive crystalline phase in simulated body fluid. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition comprises: 15-45 wt. % SiO2, 30-60 wt. % CaO, 8-30 wt. % P2O5, and 2-15 wt. % ZrO2. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises >0-25 wt. % MgO. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises 3-15 wt. % MgO. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises >0-25 wt. % SrO. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises 10-20 wt. % SrO. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises >0-25 wt. % ZnO. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises 10-20 wt. % ZnO. In aspects, which are combinable with any of the other aspects or embodiments, the glass comprises: 15-50 wt. % MO, and 0-30 wt. % R2O, wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO, and R2O is the sum of Na2O, K2O, Li2O, Rb2O, and Cs2O. In aspects, which are combinable with any of the other aspects or embodiments, the bioactive crystalline phase comprises apatite. In aspects, which are combinable with any of the other aspects or embodiments, the apatite is hydroxyapatite. In aspects, which are combinable with any of the other aspects or embodiments, a sum of P2O5 and CaO is from 25-65 wt. %. In aspects, which are combinable with any of the other aspects or embodiments, the simulated body fluid is an artificial saliva. In embodiments, a silicate-based glass composition comprises 15-45 wt. % SiO2, 30-60 wt. % CaO, 8-30 wt. % P2O5, and 2-15 wt. % ZrO2, wherein the composition: has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms an apatite crystalline phase in an artificial saliva, and wherein a sum of P2O5 and CaO is from 25-65 wt. %. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises 3-15 wt. % MgO. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises 10-20 wt. % SrO. In aspects, which are combinable with any of the other aspects or embodiments, the glass composition further comprises 10-20 wt. % ZnO. In aspects, which are combinable with any of the other aspects or embodiments, the apatite is hydroxyapatite. In aspects, which are combinable with any of the other aspects or embodiments, a matrix comprises a